Case with triple-negative breast cancer shows overexpression of both cFOS and TGF-beta 1 in node-positive tissue
Nema prikaza
Autori
Ivanović, VesnaDedović-Tanić, Nasta
Milovanović, Zorka M.
Lukić, Silvana
Nikolić, Srđan
Baltić, Vladimir
Stojiljković, Bratislav
Demajo, Miroslav
Mandušić, Vesna
Dimitrijević, Bogomir B.
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
We present herein a case report style article on a rare advanced triple-negative breast cancer (TNBC) patient with 6-month disease-free interval, and 10-month overall survival. Our results demonstrate that the poor clinical outcome of this patient was associated with pronounced, more than fivefold higher, overexpression of both cFOS and TGF-beta 1 proteins in its metastatic nodal tissue extracts, when compared with the values of the two non-TNBC controls (with zero disease-free interval and overall survival). This original observation suggests, for the first time, that both the cFOS and TGF-beta 1 may be considered as a pair of biomarkers for an early assessment of poor prognosis for TNBC patients. The possible clinical implication of this observation is discussed.
Ključne reči:
cFOS / metastatic axillary lymph nodes / TGF-beta 1 / triple-negative breast cancerIzvor:
Personalized Medicine, 2016, 13, 6, 523-530Finansiranje / projekti:
- Molekularne determinante za dizajn tumor markera (RS-173049)
DOI: 10.2217/pme-2016-0032
ISSN: 1741-0541; 1744-828X
WoS: 000389179500001
Scopus: 2-s2.0-84994558857
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Institucija/grupa
VinčaTY - JOUR AU - Ivanović, Vesna AU - Dedović-Tanić, Nasta AU - Milovanović, Zorka M. AU - Lukić, Silvana AU - Nikolić, Srđan AU - Baltić, Vladimir AU - Stojiljković, Bratislav AU - Demajo, Miroslav AU - Mandušić, Vesna AU - Dimitrijević, Bogomir B. PY - 2016 UR - https://vinar.vin.bg.ac.rs/handle/123456789/1327 AB - We present herein a case report style article on a rare advanced triple-negative breast cancer (TNBC) patient with 6-month disease-free interval, and 10-month overall survival. Our results demonstrate that the poor clinical outcome of this patient was associated with pronounced, more than fivefold higher, overexpression of both cFOS and TGF-beta 1 proteins in its metastatic nodal tissue extracts, when compared with the values of the two non-TNBC controls (with zero disease-free interval and overall survival). This original observation suggests, for the first time, that both the cFOS and TGF-beta 1 may be considered as a pair of biomarkers for an early assessment of poor prognosis for TNBC patients. The possible clinical implication of this observation is discussed. T2 - Personalized Medicine T1 - Case with triple-negative breast cancer shows overexpression of both cFOS and TGF-beta 1 in node-positive tissue VL - 13 IS - 6 SP - 523 EP - 530 DO - 10.2217/pme-2016-0032 ER -
@article{ author = "Ivanović, Vesna and Dedović-Tanić, Nasta and Milovanović, Zorka M. and Lukić, Silvana and Nikolić, Srđan and Baltić, Vladimir and Stojiljković, Bratislav and Demajo, Miroslav and Mandušić, Vesna and Dimitrijević, Bogomir B.", year = "2016", abstract = "We present herein a case report style article on a rare advanced triple-negative breast cancer (TNBC) patient with 6-month disease-free interval, and 10-month overall survival. Our results demonstrate that the poor clinical outcome of this patient was associated with pronounced, more than fivefold higher, overexpression of both cFOS and TGF-beta 1 proteins in its metastatic nodal tissue extracts, when compared with the values of the two non-TNBC controls (with zero disease-free interval and overall survival). This original observation suggests, for the first time, that both the cFOS and TGF-beta 1 may be considered as a pair of biomarkers for an early assessment of poor prognosis for TNBC patients. The possible clinical implication of this observation is discussed.", journal = "Personalized Medicine", title = "Case with triple-negative breast cancer shows overexpression of both cFOS and TGF-beta 1 in node-positive tissue", volume = "13", number = "6", pages = "523-530", doi = "10.2217/pme-2016-0032" }
Ivanović, V., Dedović-Tanić, N., Milovanović, Z. M., Lukić, S., Nikolić, S., Baltić, V., Stojiljković, B., Demajo, M., Mandušić, V.,& Dimitrijević, B. B.. (2016). Case with triple-negative breast cancer shows overexpression of both cFOS and TGF-beta 1 in node-positive tissue. in Personalized Medicine, 13(6), 523-530. https://doi.org/10.2217/pme-2016-0032
Ivanović V, Dedović-Tanić N, Milovanović ZM, Lukić S, Nikolić S, Baltić V, Stojiljković B, Demajo M, Mandušić V, Dimitrijević BB. Case with triple-negative breast cancer shows overexpression of both cFOS and TGF-beta 1 in node-positive tissue. in Personalized Medicine. 2016;13(6):523-530. doi:10.2217/pme-2016-0032 .
Ivanović, Vesna, Dedović-Tanić, Nasta, Milovanović, Zorka M., Lukić, Silvana, Nikolić, Srđan, Baltić, Vladimir, Stojiljković, Bratislav, Demajo, Miroslav, Mandušić, Vesna, Dimitrijević, Bogomir B., "Case with triple-negative breast cancer shows overexpression of both cFOS and TGF-beta 1 in node-positive tissue" in Personalized Medicine, 13, no. 6 (2016):523-530, https://doi.org/10.2217/pme-2016-0032 . .