Mitochondria are cell organelles crucial to the production of cellular energy. Several lines of evidence have indicated that mitochondrial dysfunction could be related to the pathophysiology of CNS diseases including bipolar disorder, major depressive disorder, and schizophrenia. These changes include impaired energy metabolism in the brain, co-morbidity with mitochondrial diseases, the effects of psychotropics on mitochondrial function, increased mitochondrial DNA (mtDNA) deletion in the brain, and association with mtDNA polymorphisms. Additionally, psychotropic drug treatments can alter energy metabolism and may affect mitochondrial processes. This review focuses on recent findings regarding the effects of antidepressants on mitochondrial processes in psychiatric disorders. Drug Dev Res 77 : 400-406, 2016. (c) 2016 Wiley Periodicals, Inc.
TY - JOUR
AU - Adžić, Miroslav
AU - Brkić, Željka
AU - Bulajić, Sonja
AU - Mitić, Miloš
AU - Radojčić, Marija
PY - 2016
UR - https://vinar.vin.bg.ac.rs/handle/123456789/1304
AB - Mitochondria are cell organelles crucial to the production of cellular energy. Several lines of evidence have indicated that mitochondrial dysfunction could be related to the pathophysiology of CNS diseases including bipolar disorder, major depressive disorder, and schizophrenia. These changes include impaired energy metabolism in the brain, co-morbidity with mitochondrial diseases, the effects of psychotropics on mitochondrial function, increased mitochondrial DNA (mtDNA) deletion in the brain, and association with mtDNA polymorphisms. Additionally, psychotropic drug treatments can alter energy metabolism and may affect mitochondrial processes. This review focuses on recent findings regarding the effects of antidepressants on mitochondrial processes in psychiatric disorders. Drug Dev Res 77 : 400-406, 2016. (c) 2016 Wiley Periodicals, Inc.
T2 - Drug Development Research
T1 - Antidepressant Action on Mitochondrial Dysfunction in Psychiatric Disorders
VL - 77
IS - 7
SP - 400
EP - 406
DO - 10.1002/ddr.21332
ER -
@article{
author = "Adžić, Miroslav and Brkić, Željka and Bulajić, Sonja and Mitić, Miloš and Radojčić, Marija",
year = "2016",
abstract = "Mitochondria are cell organelles crucial to the production of cellular energy. Several lines of evidence have indicated that mitochondrial dysfunction could be related to the pathophysiology of CNS diseases including bipolar disorder, major depressive disorder, and schizophrenia. These changes include impaired energy metabolism in the brain, co-morbidity with mitochondrial diseases, the effects of psychotropics on mitochondrial function, increased mitochondrial DNA (mtDNA) deletion in the brain, and association with mtDNA polymorphisms. Additionally, psychotropic drug treatments can alter energy metabolism and may affect mitochondrial processes. This review focuses on recent findings regarding the effects of antidepressants on mitochondrial processes in psychiatric disorders. Drug Dev Res 77 : 400-406, 2016. (c) 2016 Wiley Periodicals, Inc.",
journal = "Drug Development Research",
title = "Antidepressant Action on Mitochondrial Dysfunction in Psychiatric Disorders",
volume = "77",
number = "7",
pages = "400-406",
doi = "10.1002/ddr.21332"
}
Adžić, M., Brkić, Ž., Bulajić, S., Mitić, M.,& Radojčić, M.. (2016). Antidepressant Action on Mitochondrial Dysfunction in Psychiatric Disorders. in Drug Development Research, 77(7), 400-406.
https://doi.org/10.1002/ddr.21332
Adžić M, Brkić Ž, Bulajić S, Mitić M, Radojčić M. Antidepressant Action on Mitochondrial Dysfunction in Psychiatric Disorders. in Drug Development Research. 2016;77(7):400-406.
doi:10.1002/ddr.21332 .
Adžić, Miroslav, Brkić, Željka, Bulajić, Sonja, Mitić, Miloš, Radojčić, Marija, "Antidepressant Action on Mitochondrial Dysfunction in Psychiatric Disorders" in Drug Development Research, 77, no. 7 (2016):400-406,
https://doi.org/10.1002/ddr.21332 . .
