Design of novel magnetic nanostructures for targeted tumour therapy - MagBioVin Project
Само за регистроване кориснике
2016
Аутори
Illés, ErzsébetKnežević, Nikola
Mraković, Ana Đ.
Antić, Bratislav
Perović, Marija M.
Bošković, Marko
Kusigerski, Vladan
Vranješ-Đurić, Sanja
Peddis, Davide
Spasojević, Vojislav
Szytula, A.
Конференцијски прилог (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
We present here some recent research advancements and opportunities within the FP7-ERA Chairs MagBioVin project. The project aims to design various novel magnetic nanoarchitectures (e.g. bimagnetic and polymeric core-shell systems, nanoparticles embedded in mesoporous silica and radiolabeled nanostructures) for application in targeted treatment and diagnostics of cancer. The magnetic core of these nanomaterials allows the selective treatment of tumor tissues (i.e. targeted drug-delivery, localized magnetic hyperthermia) by magnetic field. Attachment of radionuclides (e.g. 90Y, 99mTc, 134I) to the nanoparticles opens the possibilities for imaging and internal radiotherapy. Magnetic nanoparticles (MNPs), i.e. iron oxides and spinel ferrites, were synthesized by different methods and coated by several compounds (e.g. citrate, polymers, silica, BSA) to increase their biocompatibility. The composition and morphology of the nanomaterials is characterized by XRD, TEM imaging and infrared spec...troscopy, while their magnetic properties were studied by SQUID magnetometry and Mössbauer spectroscopy. Magnetic hyperthermia effects were monitored by DM100 device equipped with DM1, 2 and 3 applicators (nB nanoScale Biomagnetics). This unique setup allows us to monitor the heating efficiency development in cell cultures and small animals (e.g. mice, rats) as well. The current results showed that the MNPs can be successfully labeled with 90Y and 99mTc. The drug loading and release properties of MNPs are studied by HPLC using doxorubicin as the drug. In vitro and in vivo (animal model) applicability of the synthesized nanomaterials regarding toxicity, biodistribution and anti-cancer efficacy is explored for targeted cancer treatment.
Извор:
Clinical Chemistry and Laboratory Medicine, 2016, 54, 10, eA187-Финансирање / пројекти:
Напомена:
- LVIII National Congress of the Hungarian Society of Laboratory Medicine: program and the book of abstracts : August 25–27, 2016; Szeged, Hungary
Колекције
Институција/група
VinčaTY - CONF AU - Illés, Erzsébet AU - Knežević, Nikola AU - Mraković, Ana Đ. AU - Antić, Bratislav AU - Perović, Marija M. AU - Bošković, Marko AU - Kusigerski, Vladan AU - Vranješ-Đurić, Sanja AU - Peddis, Davide AU - Spasojević, Vojislav AU - Szytula, A. PY - 2016 UR - https://vinar.vin.bg.ac.rs/handle/123456789/10828 AB - We present here some recent research advancements and opportunities within the FP7-ERA Chairs MagBioVin project. The project aims to design various novel magnetic nanoarchitectures (e.g. bimagnetic and polymeric core-shell systems, nanoparticles embedded in mesoporous silica and radiolabeled nanostructures) for application in targeted treatment and diagnostics of cancer. The magnetic core of these nanomaterials allows the selective treatment of tumor tissues (i.e. targeted drug-delivery, localized magnetic hyperthermia) by magnetic field. Attachment of radionuclides (e.g. 90Y, 99mTc, 134I) to the nanoparticles opens the possibilities for imaging and internal radiotherapy. Magnetic nanoparticles (MNPs), i.e. iron oxides and spinel ferrites, were synthesized by different methods and coated by several compounds (e.g. citrate, polymers, silica, BSA) to increase their biocompatibility. The composition and morphology of the nanomaterials is characterized by XRD, TEM imaging and infrared spectroscopy, while their magnetic properties were studied by SQUID magnetometry and Mössbauer spectroscopy. Magnetic hyperthermia effects were monitored by DM100 device equipped with DM1, 2 and 3 applicators (nB nanoScale Biomagnetics). This unique setup allows us to monitor the heating efficiency development in cell cultures and small animals (e.g. mice, rats) as well. The current results showed that the MNPs can be successfully labeled with 90Y and 99mTc. The drug loading and release properties of MNPs are studied by HPLC using doxorubicin as the drug. In vitro and in vivo (animal model) applicability of the synthesized nanomaterials regarding toxicity, biodistribution and anti-cancer efficacy is explored for targeted cancer treatment. C3 - Clinical Chemistry and Laboratory Medicine T1 - Design of novel magnetic nanostructures for targeted tumour therapy - MagBioVin Project VL - 54 IS - 10 SP - eA187 DO - 10.1515/cclm-2016-0583 ER -
@conference{ author = "Illés, Erzsébet and Knežević, Nikola and Mraković, Ana Đ. and Antić, Bratislav and Perović, Marija M. and Bošković, Marko and Kusigerski, Vladan and Vranješ-Đurić, Sanja and Peddis, Davide and Spasojević, Vojislav and Szytula, A.", year = "2016", abstract = "We present here some recent research advancements and opportunities within the FP7-ERA Chairs MagBioVin project. The project aims to design various novel magnetic nanoarchitectures (e.g. bimagnetic and polymeric core-shell systems, nanoparticles embedded in mesoporous silica and radiolabeled nanostructures) for application in targeted treatment and diagnostics of cancer. The magnetic core of these nanomaterials allows the selective treatment of tumor tissues (i.e. targeted drug-delivery, localized magnetic hyperthermia) by magnetic field. Attachment of radionuclides (e.g. 90Y, 99mTc, 134I) to the nanoparticles opens the possibilities for imaging and internal radiotherapy. Magnetic nanoparticles (MNPs), i.e. iron oxides and spinel ferrites, were synthesized by different methods and coated by several compounds (e.g. citrate, polymers, silica, BSA) to increase their biocompatibility. The composition and morphology of the nanomaterials is characterized by XRD, TEM imaging and infrared spectroscopy, while their magnetic properties were studied by SQUID magnetometry and Mössbauer spectroscopy. Magnetic hyperthermia effects were monitored by DM100 device equipped with DM1, 2 and 3 applicators (nB nanoScale Biomagnetics). This unique setup allows us to monitor the heating efficiency development in cell cultures and small animals (e.g. mice, rats) as well. The current results showed that the MNPs can be successfully labeled with 90Y and 99mTc. The drug loading and release properties of MNPs are studied by HPLC using doxorubicin as the drug. In vitro and in vivo (animal model) applicability of the synthesized nanomaterials regarding toxicity, biodistribution and anti-cancer efficacy is explored for targeted cancer treatment.", journal = "Clinical Chemistry and Laboratory Medicine", title = "Design of novel magnetic nanostructures for targeted tumour therapy - MagBioVin Project", volume = "54", number = "10", pages = "eA187", doi = "10.1515/cclm-2016-0583" }
Illés, E., Knežević, N., Mraković, A. Đ., Antić, B., Perović, M. M., Bošković, M., Kusigerski, V., Vranješ-Đurić, S., Peddis, D., Spasojević, V.,& Szytula, A.. (2016). Design of novel magnetic nanostructures for targeted tumour therapy - MagBioVin Project. in Clinical Chemistry and Laboratory Medicine, 54(10), eA187. https://doi.org/10.1515/cclm-2016-0583
Illés E, Knežević N, Mraković AĐ, Antić B, Perović MM, Bošković M, Kusigerski V, Vranješ-Đurić S, Peddis D, Spasojević V, Szytula A. Design of novel magnetic nanostructures for targeted tumour therapy - MagBioVin Project. in Clinical Chemistry and Laboratory Medicine. 2016;54(10):eA187. doi:10.1515/cclm-2016-0583 .
Illés, Erzsébet, Knežević, Nikola, Mraković, Ana Đ., Antić, Bratislav, Perović, Marija M., Bošković, Marko, Kusigerski, Vladan, Vranješ-Đurić, Sanja, Peddis, Davide, Spasojević, Vojislav, Szytula, A., "Design of novel magnetic nanostructures for targeted tumour therapy - MagBioVin Project" in Clinical Chemistry and Laboratory Medicine, 54, no. 10 (2016):eA187, https://doi.org/10.1515/cclm-2016-0583 . .