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99mTc-Labeled Iron Oxide Nanoparticles as Dual-Modality Contrast Agent: A Preliminary Study from Synthesis to Magnetic Resonance and Gamma-Camera Imaging in Mice Models
dc.creator | Karageorgou, Maria-Argyro | |
dc.creator | Rapsomanikis, Aristotelis-Nikolaos | |
dc.creator | Mirković, Marija D. | |
dc.creator | Vranješ-Đurić, Sanja | |
dc.creator | Stiliaris, Efstathios | |
dc.creator | Bouziotis, Penelope | |
dc.creator | Stamopoulos, Dimosthenis | |
dc.date.accessioned | 2022-09-18T09:54:03Z | |
dc.date.available | 2022-09-18T09:54:03Z | |
dc.date.issued | 2022 | |
dc.identifier.issn | 2079-4991 | |
dc.identifier.uri | https://vinar.vin.bg.ac.rs/handle/123456789/10405 | |
dc.description.abstract | The combination of two imaging modalities in a single agent has received increasing attention during the last few years, since its synergistic action guarantees both accurate and timely diagnosis. For this reason, dual-modality contrast agents (DMCAs), such as radiolabeled iron oxide (namely Fe3O4) nanoparticles, constitute a powerful tool in diagnostic applications. In this respect, here we focus on the synthesis of a potential single photon emission computed tomography/magnetic resonance imaging (SPECT/MRI) DMCA, which consists of Fe3O4 nanoparticles, surface functionalized with 2,3-dicarboxypropane-1,1-diphosphonic acid (DPD) and radiolabeled with 99mTc, [99mTc]Tc-DPD-Fe3O4. The in vitro stability results showed that this DMCA is highly stable after 24 h of incubation in phosphate buffer saline (~92.3% intact), while it is adequately stable after 24 h of incubation with human serum (~67.3% intact). Subsequently, [99mTc]Tc-DPD-Fe3O4 DMCA was evaluated in vivo in mice models through standard biodistribution studies, MR imaging and gamma-camera imaging. All techniques provided consistent results, clearly evidencing noticeable liver uptake. Our work documents that [99mTc]Tc-DPD-Fe3O4 has all the necessary characteristics to be a potential DMCA. | en |
dc.language | en | |
dc.rights | openAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.source | Nanomaterials | |
dc.subject | biodistribution | en |
dc.subject | dual-modality contrast agents | en |
dc.subject | gamma-camera imaging | en |
dc.subject | in vitro stability | en |
dc.subject | magnetic resonance imaging | en |
dc.subject | radiolabeling | en |
dc.subject | technetium-99m | en |
dc.title | 99mTc-Labeled Iron Oxide Nanoparticles as Dual-Modality Contrast Agent: A Preliminary Study from Synthesis to Magnetic Resonance and Gamma-Camera Imaging in Mice Models | en |
dc.type | article | en |
dc.rights.license | BY | |
dc.citation.volume | 12 | |
dc.citation.issue | 15 | |
dc.citation.spage | 2728 | |
dc.identifier.wos | 00083994430000 | |
dc.identifier.doi | 10.3390/nano12152728 | |
dc.type.version | publishedVersion | |
dc.identifier.scopus | 2-s2.0-85136923889 | |
dc.identifier.fulltext | http://vinar.vin.bg.ac.rs/bitstream/id/26845/nanomaterials-12-02728.pdf |
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070 - Laboratorija za radioizotope
Department of Radioisotopes -
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