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The influence of host factors and sequence variability of the p7 region on the response to pegylated interferon/ribavirin therapy for chronic hepatitis C genotype 1b in patients from Serbia
dc.creator | Jovanović-Ćupić, Snežana P. | |
dc.creator | Glišić, Sanja | |
dc.creator | Stanojevic, Maja | |
dc.creator | Nozic, Darko | |
dc.creator | Petrović, Nina | |
dc.creator | Mandušić, Vesna | |
dc.creator | Krajnović, Milena M. | |
dc.date.accessioned | 2018-03-01T16:50:11Z | |
dc.date.available | 2018-03-01T16:50:11Z | |
dc.date.issued | 2016 | |
dc.identifier.issn | 0304-8608 | |
dc.identifier.issn | 1432-8798 | |
dc.identifier.uri | https://vinar.vin.bg.ac.rs/handle/123456789/1032 | |
dc.description.abstract | The goal of this study was to identify host and viral factors affecting the response to pegylated interferon/ribavirin (PEG-IFN/RBV) treatment in patients with chronic hepatitis C genotype 1b. Baseline characteristics of the patients and sequences within the p7 region were analyzed in pre-treatment serum samples from 53 individuals with chronic hepatitis C genotype 1b and related to the outcome of therapy. We found a significant correlation between age and response to therapy (p LT 0.001). Furthermore, the pre-treatment viral load was closely associated with the stage of liver fibrosis (p LT 0.001). The presence of fewer than 4 mutations and age above 40 were significantly associated with non-response (NR) (p LT 0.001). Our findings may be useful for estimating the likelihood of achieving a sustained virologic response (SVR) in patients who are chronically infected with hepatitis C virus genotype 1b. | en |
dc.publisher | Springer | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173049/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175024/RS// | |
dc.rights | restrictedAccess | en |
dc.source | Archives of Virology | en |
dc.title | The influence of host factors and sequence variability of the p7 region on the response to pegylated interferon/ribavirin therapy for chronic hepatitis C genotype 1b in patients from Serbia | en |
dc.type | article | en |
dc.rights.license | ARR | |
dcterms.abstract | Нозиц, Дарко; Јовановић-Ћупић Снежана; Глишић Сања; Станојевиц, Маја; Петровић Нина; Мандушић Весна; Крајновић Милена; | |
dc.citation.volume | 161 | |
dc.citation.issue | 5 | |
dc.citation.spage | 1189 | |
dc.citation.epage | 1198 | |
dc.identifier.wos | 000374557100009 | |
dc.identifier.doi | 10.1007/s00705-016-2777-z | |
dc.citation.rank | M23 | |
dc.identifier.pmid | 26860912 | |
dc.type.version | publishedVersion | |
dc.identifier.scopus | 2-s2.0-84957703934 |