Fructose-rich diet and walnut supplementation differently regulate rat hypothalamic and hippocampal glucose transporters expression
Samo za registrovane korisnike
2021
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Nutritional modulations may be considered a strategy to protect mental health. Neuronal homeostasis is highly dependent on the availability of glucose, which represents the primary energy source for the brain. In this study, we evaluated the effects of walnut intake and fructose-rich diet on the expression of glucose transporters (GLUTs) in two rat brain regions: hypothalamus and hippocampus. RESULTS Our results show that walnut supplementation of fructose-fed animals restored the hypothalamic content of GLUT1 and GLUT3 protein. Furthermore, walnut intake did not affect increased hypothalamic GLUT2 content upon fructose consumption. These effects were accompanied by distinctive alterations of hippocampal GLUTs levels. Specifically, walnut intake increased GLUT1 content, whereas GLUT2 protein was decreased within the rat hippocampus after both individual and combined treatments. CONCLUSION Overall, our study suggests that walnut supplementation exerted modulatory effects on the glucose ...transporters within specific brain regions in the presence of developed metabolic disorder. © 2021 Society of Chemical Industry.
Ključne reči:
fructose / glucose transporters / hippocampus / hypothalamus / walnutIzvor:
Journal of the Science of Food and Agriculture, 2021, 101, 14, 5984-5991Finansiranje / projekti:
- Ministarstvo nauke, tehnološkog razvoja i inovacija Republike Srbije, institucionalno finansiranje - 200017 (Univerzitet u Beogradu, Institut za nuklearne nauke Vinča, Beograd-Vinča) (RS-MESTD-inst-2020-200017)
- Ministarstvo nauke, tehnološkog razvoja i inovacija Republike Srbije, institucionalno finansiranje - 200015 (Univerzitet u Beogradu, Institut za medicinska istraživanja) (RS-MESTD-inst-2020-200015)
- Ministarstvo nauke, tehnološkog razvoja i inovacija Republike Srbije, institucionalno finansiranje - 200178 (Univerzitet u Beogradu, Biološki fakultet) (RS-MESTD-inst-2020-200178)
DOI: 10.1002/jsfa.11252
ISSN: 1097-0010
PubMed: 33856052
WoS: 000644854300001
Scopus: 2-s2.0-85116228982
Kolekcije
Institucija/grupa
VinčaTY - JOUR AU - Dakić, Tamara AU - Lakić, Iva AU - Zec, Manja AU - Takić, Marija AU - Stojiljković, Mojca D. AU - Jevđović, Tanja PY - 2021 UR - https://vinar.vin.bg.ac.rs/handle/123456789/9973 AB - Nutritional modulations may be considered a strategy to protect mental health. Neuronal homeostasis is highly dependent on the availability of glucose, which represents the primary energy source for the brain. In this study, we evaluated the effects of walnut intake and fructose-rich diet on the expression of glucose transporters (GLUTs) in two rat brain regions: hypothalamus and hippocampus. RESULTS Our results show that walnut supplementation of fructose-fed animals restored the hypothalamic content of GLUT1 and GLUT3 protein. Furthermore, walnut intake did not affect increased hypothalamic GLUT2 content upon fructose consumption. These effects were accompanied by distinctive alterations of hippocampal GLUTs levels. Specifically, walnut intake increased GLUT1 content, whereas GLUT2 protein was decreased within the rat hippocampus after both individual and combined treatments. CONCLUSION Overall, our study suggests that walnut supplementation exerted modulatory effects on the glucose transporters within specific brain regions in the presence of developed metabolic disorder. © 2021 Society of Chemical Industry. T2 - Journal of the Science of Food and Agriculture T1 - Fructose-rich diet and walnut supplementation differently regulate rat hypothalamic and hippocampal glucose transporters expression VL - 101 IS - 14 SP - 5984 EP - 5991 DO - 10.1002/jsfa.11252 ER -
@article{ author = "Dakić, Tamara and Lakić, Iva and Zec, Manja and Takić, Marija and Stojiljković, Mojca D. and Jevđović, Tanja", year = "2021", abstract = "Nutritional modulations may be considered a strategy to protect mental health. Neuronal homeostasis is highly dependent on the availability of glucose, which represents the primary energy source for the brain. In this study, we evaluated the effects of walnut intake and fructose-rich diet on the expression of glucose transporters (GLUTs) in two rat brain regions: hypothalamus and hippocampus. RESULTS Our results show that walnut supplementation of fructose-fed animals restored the hypothalamic content of GLUT1 and GLUT3 protein. Furthermore, walnut intake did not affect increased hypothalamic GLUT2 content upon fructose consumption. These effects were accompanied by distinctive alterations of hippocampal GLUTs levels. Specifically, walnut intake increased GLUT1 content, whereas GLUT2 protein was decreased within the rat hippocampus after both individual and combined treatments. CONCLUSION Overall, our study suggests that walnut supplementation exerted modulatory effects on the glucose transporters within specific brain regions in the presence of developed metabolic disorder. © 2021 Society of Chemical Industry.", journal = "Journal of the Science of Food and Agriculture", title = "Fructose-rich diet and walnut supplementation differently regulate rat hypothalamic and hippocampal glucose transporters expression", volume = "101", number = "14", pages = "5984-5991", doi = "10.1002/jsfa.11252" }
Dakić, T., Lakić, I., Zec, M., Takić, M., Stojiljković, M. D.,& Jevđović, T.. (2021). Fructose-rich diet and walnut supplementation differently regulate rat hypothalamic and hippocampal glucose transporters expression. in Journal of the Science of Food and Agriculture, 101(14), 5984-5991. https://doi.org/10.1002/jsfa.11252
Dakić T, Lakić I, Zec M, Takić M, Stojiljković MD, Jevđović T. Fructose-rich diet and walnut supplementation differently regulate rat hypothalamic and hippocampal glucose transporters expression. in Journal of the Science of Food and Agriculture. 2021;101(14):5984-5991. doi:10.1002/jsfa.11252 .
Dakić, Tamara, Lakić, Iva, Zec, Manja, Takić, Marija, Stojiljković, Mojca D., Jevđović, Tanja, "Fructose-rich diet and walnut supplementation differently regulate rat hypothalamic and hippocampal glucose transporters expression" in Journal of the Science of Food and Agriculture, 101, no. 14 (2021):5984-5991, https://doi.org/10.1002/jsfa.11252 . .