Simulation-based correction of dose enhancement factor values in photon brachytherapy with metal nanoparticle targeting
Само за регистроване кориснике
2020
Чланак у часопису (Објављена верзија)
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The purpose of this study is to investigate and quantify the influence of nanoparticle composition, size, and concentration on the difference between dose enhancement values derived from Monte Carlo simulations with homogeneous and structured geometrical representations of the target region in metal nanoparticle-enhanced photon brachytherapy. Values of the dose enhancement factor (DEF) were calculated for Pd-103, I-125, and Cs-131 brachytherapy sources with gold, silver, or platinum nanoparticles acting as targeting agents. Simulations were performed using the Geant4 toolkit with condensed history models of electron transport. Stringent limits were imposed on adjustable parameters that define secondary electron histories, so that simulations came closest to true event-by-event electron tracking, thereby allowing part of the nanoparticle-laden volume used for calculating the dose to be represented as a structured region with uniformly distributed discrete nanoparticles. Fine-tuned physi...cal models of secondary radiation emission and propagation, along with the discrete geometrical representation of nanoparticles, result in a more realistic assessment of dose enhancement. The DEF correction coefficient is introduced as a metric that quantifies the absorption of secondary radiation inside the nanoparticles themselves, a phenomenon disregarded when the target region is treated as a homogeneous metal–tissue mixture, but accounted for by discrete nanoparticle representation. The approach applied to correcting DEF values both draws from and expands upon several related investigations published previously. Comparison of the obtained results to those found in relevant references shows both agreement and deviation, depending on nanoparticle properties and photon energy. © 2020, China Science Publishing & Media Ltd. (Science Press), Shanghai Institute of Applied Physics, the Chinese Academy of Sciences, Chinese Nuclear Society and Springer Nature Singapore Pte Ltd.
Кључне речи:
Brachytherapy / Dose enhancement / Geant4 / Monte Carlo / NanoparticlesИзвор:
Nuclear Science and Techniques, 2020, 31, 11Финансирање / пројекти:
- Испитивање и верификација метода за мултидисциплинарне форензичке анализе у функцији непролиферације оружја за масовно уништење (RS-MESTD-Technological Development (TD or TR)-37021)
- Физички и функционални ефекти интеракције зрачења са електротехничким и биолошким системима (RS-MESTD-Basic Research (BR or ON)-171007)
DOI: 10.1007/s41365-020-00820-8
ISSN: 1001-8042
WoS: 000590989400001
Scopus: 2-s2.0-85096229595
Колекције
Институција/група
VinčaTY - JOUR AU - Milutinović, Slobodan AU - Vujisić, Miloš Lj. PY - 2020 UR - https://vinar.vin.bg.ac.rs/handle/123456789/9740 AB - The purpose of this study is to investigate and quantify the influence of nanoparticle composition, size, and concentration on the difference between dose enhancement values derived from Monte Carlo simulations with homogeneous and structured geometrical representations of the target region in metal nanoparticle-enhanced photon brachytherapy. Values of the dose enhancement factor (DEF) were calculated for Pd-103, I-125, and Cs-131 brachytherapy sources with gold, silver, or platinum nanoparticles acting as targeting agents. Simulations were performed using the Geant4 toolkit with condensed history models of electron transport. Stringent limits were imposed on adjustable parameters that define secondary electron histories, so that simulations came closest to true event-by-event electron tracking, thereby allowing part of the nanoparticle-laden volume used for calculating the dose to be represented as a structured region with uniformly distributed discrete nanoparticles. Fine-tuned physical models of secondary radiation emission and propagation, along with the discrete geometrical representation of nanoparticles, result in a more realistic assessment of dose enhancement. The DEF correction coefficient is introduced as a metric that quantifies the absorption of secondary radiation inside the nanoparticles themselves, a phenomenon disregarded when the target region is treated as a homogeneous metal–tissue mixture, but accounted for by discrete nanoparticle representation. The approach applied to correcting DEF values both draws from and expands upon several related investigations published previously. Comparison of the obtained results to those found in relevant references shows both agreement and deviation, depending on nanoparticle properties and photon energy. © 2020, China Science Publishing & Media Ltd. (Science Press), Shanghai Institute of Applied Physics, the Chinese Academy of Sciences, Chinese Nuclear Society and Springer Nature Singapore Pte Ltd. T2 - Nuclear Science and Techniques T1 - Simulation-based correction of dose enhancement factor values in photon brachytherapy with metal nanoparticle targeting VL - 31 IS - 11 DO - 10.1007/s41365-020-00820-8 ER -
@article{ author = "Milutinović, Slobodan and Vujisić, Miloš Lj.", year = "2020", abstract = "The purpose of this study is to investigate and quantify the influence of nanoparticle composition, size, and concentration on the difference between dose enhancement values derived from Monte Carlo simulations with homogeneous and structured geometrical representations of the target region in metal nanoparticle-enhanced photon brachytherapy. Values of the dose enhancement factor (DEF) were calculated for Pd-103, I-125, and Cs-131 brachytherapy sources with gold, silver, or platinum nanoparticles acting as targeting agents. Simulations were performed using the Geant4 toolkit with condensed history models of electron transport. Stringent limits were imposed on adjustable parameters that define secondary electron histories, so that simulations came closest to true event-by-event electron tracking, thereby allowing part of the nanoparticle-laden volume used for calculating the dose to be represented as a structured region with uniformly distributed discrete nanoparticles. Fine-tuned physical models of secondary radiation emission and propagation, along with the discrete geometrical representation of nanoparticles, result in a more realistic assessment of dose enhancement. The DEF correction coefficient is introduced as a metric that quantifies the absorption of secondary radiation inside the nanoparticles themselves, a phenomenon disregarded when the target region is treated as a homogeneous metal–tissue mixture, but accounted for by discrete nanoparticle representation. The approach applied to correcting DEF values both draws from and expands upon several related investigations published previously. Comparison of the obtained results to those found in relevant references shows both agreement and deviation, depending on nanoparticle properties and photon energy. © 2020, China Science Publishing & Media Ltd. (Science Press), Shanghai Institute of Applied Physics, the Chinese Academy of Sciences, Chinese Nuclear Society and Springer Nature Singapore Pte Ltd.", journal = "Nuclear Science and Techniques", title = "Simulation-based correction of dose enhancement factor values in photon brachytherapy with metal nanoparticle targeting", volume = "31", number = "11", doi = "10.1007/s41365-020-00820-8" }
Milutinović, S.,& Vujisić, M. Lj.. (2020). Simulation-based correction of dose enhancement factor values in photon brachytherapy with metal nanoparticle targeting. in Nuclear Science and Techniques, 31(11). https://doi.org/10.1007/s41365-020-00820-8
Milutinović S, Vujisić ML. Simulation-based correction of dose enhancement factor values in photon brachytherapy with metal nanoparticle targeting. in Nuclear Science and Techniques. 2020;31(11). doi:10.1007/s41365-020-00820-8 .
Milutinović, Slobodan, Vujisić, Miloš Lj., "Simulation-based correction of dose enhancement factor values in photon brachytherapy with metal nanoparticle targeting" in Nuclear Science and Techniques, 31, no. 11 (2020), https://doi.org/10.1007/s41365-020-00820-8 . .