Calcium signaling modulates the dynamics of cilia and flagella

Satarić, Miljko V.; Zdravković, Slobodan; Nemeš, Tomas; Satarić, Bogdan M.

doi:10.1007/s00249-020-01471-8

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2020

Authors

Satarić, Miljko V.
Zdravković, Slobodan

Nemeš, Tomas

Satarić, Bogdan M.

Article (Published version)

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Abstract

To adapt to changing environments cells must signal and signaling requires messengers whose concentration varies with time in space. We here consider the messenger role of calcium ions implicated in regulation of the wave-like bending dynamics of cilia and flagella. The emphasis is on microtubules as polyelectrolytes serving as transmission lines for the flow of Ca2+ signals in the axoneme. This signaling is superimposed with a geometric clutch mechanism for the regulation of flagella bending dynamics and our modeling produces results in agreement with experimental data.

Keywords:

Calcium signaling / Cilium / Dynein motors / Flagellum / Microtubule

Source:
European Biophysics Journal, 2020, 49, 7, 619-631

Funding / projects:

The influence of elementary excitations and conformations to physical properties of the new materials based on strongly correlated low-dimensional systems (RS-171009)
Development of the methods, sensors and systems for monitoring quality of water, air and soil (RS-43008)
Photonics of micro and nano structured materials (RS-45010)
Provincial Secretariat for Higher Education and Scientific Research of AP Vojvodina [1144512708/201603]

DOI: 10.1007/s00249-020-01471-8

ISSN: 1432-1017

PubMed: 33105487

WoS: 000583986100001

Scopus: 2-s2.0-85094167202

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	1
	1

TY  - JOUR
AU  - Satarić, Miljko V.
AU  - Zdravković, Slobodan
AU  - Nemeš, Tomas
AU  - Satarić, Bogdan M.
PY  - 2020
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9719
AB  - To adapt to changing environments cells must signal and signaling requires messengers whose concentration varies with time in space. We here consider the messenger role of calcium ions implicated in regulation of the wave-like bending dynamics of cilia and flagella. The emphasis is on microtubules as polyelectrolytes serving as transmission lines for the flow of Ca2+ signals in the axoneme. This signaling is superimposed with a geometric clutch mechanism for the regulation of flagella bending dynamics and our modeling produces results in agreement with experimental data.
T2  - European Biophysics Journal
T1  - Calcium signaling modulates the dynamics of cilia and flagella
VL  - 49
IS  - 7
SP  - 619
EP  - 631
DO  - 10.1007/s00249-020-01471-8
ER  -

@article{
author = "Satarić, Miljko V. and Zdravković, Slobodan and Nemeš, Tomas and Satarić, Bogdan M.",
year = "2020",
abstract = "To adapt to changing environments cells must signal and signaling requires messengers whose concentration varies with time in space. We here consider the messenger role of calcium ions implicated in regulation of the wave-like bending dynamics of cilia and flagella. The emphasis is on microtubules as polyelectrolytes serving as transmission lines for the flow of Ca2+ signals in the axoneme. This signaling is superimposed with a geometric clutch mechanism for the regulation of flagella bending dynamics and our modeling produces results in agreement with experimental data.",
journal = "European Biophysics Journal",
title = "Calcium signaling modulates the dynamics of cilia and flagella",
volume = "49",
number = "7",
pages = "619-631",
doi = "10.1007/s00249-020-01471-8"
}

Satarić, M. V., Zdravković, S., Nemeš, T.,& Satarić, B. M.. (2020). Calcium signaling modulates the dynamics of cilia and flagella. in European Biophysics Journal, 49(7), 619-631.
https://doi.org/10.1007/s00249-020-01471-8

Satarić MV, Zdravković S, Nemeš T, Satarić BM. Calcium signaling modulates the dynamics of cilia and flagella. in European Biophysics Journal. 2020;49(7):619-631.
doi:10.1007/s00249-020-01471-8 .

Satarić, Miljko V., Zdravković, Slobodan, Nemeš, Tomas, Satarić, Bogdan M., "Calcium signaling modulates the dynamics of cilia and flagella" in European Biophysics Journal, 49, no. 7 (2020):619-631,
https://doi.org/10.1007/s00249-020-01471-8 . .