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Atherosclerosis Linked to Aberrant Amino Acid Metabolism and Immunosuppressive Amino Acid Catabolizing Enzymes

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2020
Main article [PDF] (2.313Mb)
Authors
Zarić, Božidarka
Radovanović, Jelena N.
Gluvić, Zoran
Stewart, Alan J.
Essack, Magbubah
Motwalli, Olaa
Gojobori, Takashi
Isenović, Esma R.
Article (Published version)
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Abstract
Cardiovascular disease is the leading global health concern and responsible for more deaths worldwide than any other type of disorder. Atherosclerosis is a chronic inflammatory disease in the arterial wall, which underpins several types of cardiovascular disease. It has emerged that a strong relationship exists between alterations in amino acid (AA) metabolism and the development of atherosclerosis. Recent studies have reported positive correlations between levels of branched-chain amino acids (BCAAs) such as leucine, valine, and isoleucine in plasma and the occurrence of metabolic disturbances. Elevated serum levels of BCAAs indicate a high cardiometabolic risk. Thus, BCAAs may also impact atherosclerosis prevention and offer a novel therapeutic strategy for specific individuals at risk of coronary events. The metabolism of AAs, such as L-arginine, homoarginine, and L-tryptophan, is recognized as a critical regulator of vascular homeostasis. Dietary intake of homoarginine, taurine, an...d glycine can improve atherosclerosis by endothelium remodeling. Available data also suggest that the regulation of AA metabolism by indoleamine 2,3-dioxygenase (IDO) and arginases 1 and 2 are mediated through various immunological signals and that immunosuppressive AA metabolizing enzymes are promising therapeutic targets against atherosclerosis. Further clinical studies and basic studies that make use of animal models are required. Here we review recent data examining links between AA metabolism and the development of atherosclerosis.

Keywords:
amino acid / amino acids / tryptophan / arginine / branched-chain amino acids / metabolism / atherosclerosis
Source:
Frontiers in Immunology, 2020, 11, 2341-
Funding / projects:
  • Ministry of Education, Science and Technological Development of the Republic of Serbia
  • KAUST grant OSR#4129 (EI and TG)
  • KAUST Base Research Funds BAS/1/1059-01-01
  • KAUST (OSR) [No. FCC/1/1976-17-01]

DOI: 10.3389/fimmu.2020.551758

ISSN: 1664-3224

PubMed: 33117340

WoS: 000579031100001

Scopus: 2-s2.0-85092508235
[ Google Scholar ]
27
8
URI
https://vinar.vin.bg.ac.rs/handle/123456789/9681
Collections
  • Radovi istraživača
Institution/Community
Vinča
TY  - JOUR
AU  - Zarić, Božidarka
AU  - Radovanović, Jelena N.
AU  - Gluvić, Zoran
AU  - Stewart, Alan J.
AU  - Essack, Magbubah
AU  - Motwalli, Olaa
AU  - Gojobori, Takashi
AU  - Isenović, Esma R.
PY  - 2020
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9681
AB  - Cardiovascular disease is the leading global health concern and responsible for more deaths worldwide than any other type of disorder. Atherosclerosis is a chronic inflammatory disease in the arterial wall, which underpins several types of cardiovascular disease. It has emerged that a strong relationship exists between alterations in amino acid (AA) metabolism and the development of atherosclerosis. Recent studies have reported positive correlations between levels of branched-chain amino acids (BCAAs) such as leucine, valine, and isoleucine in plasma and the occurrence of metabolic disturbances. Elevated serum levels of BCAAs indicate a high cardiometabolic risk. Thus, BCAAs may also impact atherosclerosis prevention and offer a novel therapeutic strategy for specific individuals at risk of coronary events. The metabolism of AAs, such as L-arginine, homoarginine, and L-tryptophan, is recognized as a critical regulator of vascular homeostasis. Dietary intake of homoarginine, taurine, and glycine can improve atherosclerosis by endothelium remodeling. Available data also suggest that the regulation of AA metabolism by indoleamine 2,3-dioxygenase (IDO) and arginases 1 and 2 are mediated through various immunological signals and that immunosuppressive AA metabolizing enzymes are promising therapeutic targets against atherosclerosis. Further clinical studies and basic studies that make use of animal models are required. Here we review recent data examining links between AA metabolism and the development of atherosclerosis.
T2  - Frontiers in Immunology
T1  - Atherosclerosis Linked to Aberrant Amino Acid Metabolism and Immunosuppressive Amino Acid Catabolizing Enzymes
VL  - 11
SP  - 2341
DO  - 10.3389/fimmu.2020.551758
ER  - 
@article{
author = "Zarić, Božidarka and Radovanović, Jelena N. and Gluvić, Zoran and Stewart, Alan J. and Essack, Magbubah and Motwalli, Olaa and Gojobori, Takashi and Isenović, Esma R.",
year = "2020",
abstract = "Cardiovascular disease is the leading global health concern and responsible for more deaths worldwide than any other type of disorder. Atherosclerosis is a chronic inflammatory disease in the arterial wall, which underpins several types of cardiovascular disease. It has emerged that a strong relationship exists between alterations in amino acid (AA) metabolism and the development of atherosclerosis. Recent studies have reported positive correlations between levels of branched-chain amino acids (BCAAs) such as leucine, valine, and isoleucine in plasma and the occurrence of metabolic disturbances. Elevated serum levels of BCAAs indicate a high cardiometabolic risk. Thus, BCAAs may also impact atherosclerosis prevention and offer a novel therapeutic strategy for specific individuals at risk of coronary events. The metabolism of AAs, such as L-arginine, homoarginine, and L-tryptophan, is recognized as a critical regulator of vascular homeostasis. Dietary intake of homoarginine, taurine, and glycine can improve atherosclerosis by endothelium remodeling. Available data also suggest that the regulation of AA metabolism by indoleamine 2,3-dioxygenase (IDO) and arginases 1 and 2 are mediated through various immunological signals and that immunosuppressive AA metabolizing enzymes are promising therapeutic targets against atherosclerosis. Further clinical studies and basic studies that make use of animal models are required. Here we review recent data examining links between AA metabolism and the development of atherosclerosis.",
journal = "Frontiers in Immunology",
title = "Atherosclerosis Linked to Aberrant Amino Acid Metabolism and Immunosuppressive Amino Acid Catabolizing Enzymes",
volume = "11",
pages = "2341",
doi = "10.3389/fimmu.2020.551758"
}
Zarić, B., Radovanović, J. N., Gluvić, Z., Stewart, A. J., Essack, M., Motwalli, O., Gojobori, T.,& Isenović, E. R.. (2020). Atherosclerosis Linked to Aberrant Amino Acid Metabolism and Immunosuppressive Amino Acid Catabolizing Enzymes. in Frontiers in Immunology, 11, 2341.
https://doi.org/10.3389/fimmu.2020.551758
Zarić B, Radovanović JN, Gluvić Z, Stewart AJ, Essack M, Motwalli O, Gojobori T, Isenović ER. Atherosclerosis Linked to Aberrant Amino Acid Metabolism and Immunosuppressive Amino Acid Catabolizing Enzymes. in Frontiers in Immunology. 2020;11:2341.
doi:10.3389/fimmu.2020.551758 .
Zarić, Božidarka, Radovanović, Jelena N., Gluvić, Zoran, Stewart, Alan J., Essack, Magbubah, Motwalli, Olaa, Gojobori, Takashi, Isenović, Esma R., "Atherosclerosis Linked to Aberrant Amino Acid Metabolism and Immunosuppressive Amino Acid Catabolizing Enzymes" in Frontiers in Immunology, 11 (2020):2341,
https://doi.org/10.3389/fimmu.2020.551758 . .

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