Higher-order connectivity in complex systems described by simplexes of different orders provides a geometry for simplex-based dynamical variables and interactions. Simplicial complexes that constitute a functional geometry of the human connectome can be crucial for the brain complex dynamics. In this context, the best-connected brain areas, designated as hub nodes, play a central role in supporting integrated brain function. Here, we study the structure of simplicial complexes attached to eight global hubs in the female and male connectomes and identify the core networks among the affected brain regions. These eight hubs (Putamen, Caudate, Hippocampus and Thalamus-Proper in the left and right cerebral hemisphere) are the highest-ranking according to their topological dimension, defined as the number of simplexes of all orders in which the node participates. Furthermore, we analyse the weight-dependent heterogeneity of simplexes. We demonstrate changes in the structure of identified cor...e networks and topological entropy when the threshold weight is gradually increased. These results highlight the role of higher-order interactions in human brain networks and provide additional evidence for (dis)similarity between the female and male connectomes.
Кључне речи:
project / network / connectivity
Извор:
Scientific Reports, 2020, 10, 1, 17320-
Финансирање / пројекти:
Ministry of Education, Science and Technological Development of the Republic of Serbia
TY - JOUR
AU - Anđelković, Miroslav
AU - Tadić, Bosiljka
AU - Melnik, Roderick
PY - 2020
UR - https://vinar.vin.bg.ac.rs/handle/123456789/9677
AB - Higher-order connectivity in complex systems described by simplexes of different orders provides a geometry for simplex-based dynamical variables and interactions. Simplicial complexes that constitute a functional geometry of the human connectome can be crucial for the brain complex dynamics. In this context, the best-connected brain areas, designated as hub nodes, play a central role in supporting integrated brain function. Here, we study the structure of simplicial complexes attached to eight global hubs in the female and male connectomes and identify the core networks among the affected brain regions. These eight hubs (Putamen, Caudate, Hippocampus and Thalamus-Proper in the left and right cerebral hemisphere) are the highest-ranking according to their topological dimension, defined as the number of simplexes of all orders in which the node participates. Furthermore, we analyse the weight-dependent heterogeneity of simplexes. We demonstrate changes in the structure of identified core networks and topological entropy when the threshold weight is gradually increased. These results highlight the role of higher-order interactions in human brain networks and provide additional evidence for (dis)similarity between the female and male connectomes.
T2 - Scientific Reports
T1 - The topology of higher-order complexes associated with brain hubs in human connectomes
VL - 10
IS - 1
SP - 17320
DO - 10.1038/s41598-020-74392-3
ER -
@article{
author = "Anđelković, Miroslav and Tadić, Bosiljka and Melnik, Roderick",
year = "2020",
abstract = "Higher-order connectivity in complex systems described by simplexes of different orders provides a geometry for simplex-based dynamical variables and interactions. Simplicial complexes that constitute a functional geometry of the human connectome can be crucial for the brain complex dynamics. In this context, the best-connected brain areas, designated as hub nodes, play a central role in supporting integrated brain function. Here, we study the structure of simplicial complexes attached to eight global hubs in the female and male connectomes and identify the core networks among the affected brain regions. These eight hubs (Putamen, Caudate, Hippocampus and Thalamus-Proper in the left and right cerebral hemisphere) are the highest-ranking according to their topological dimension, defined as the number of simplexes of all orders in which the node participates. Furthermore, we analyse the weight-dependent heterogeneity of simplexes. We demonstrate changes in the structure of identified core networks and topological entropy when the threshold weight is gradually increased. These results highlight the role of higher-order interactions in human brain networks and provide additional evidence for (dis)similarity between the female and male connectomes.",
journal = "Scientific Reports",
title = "The topology of higher-order complexes associated with brain hubs in human connectomes",
volume = "10",
number = "1",
pages = "17320",
doi = "10.1038/s41598-020-74392-3"
}
Anđelković, M., Tadić, B.,& Melnik, R.. (2020). The topology of higher-order complexes associated with brain hubs in human connectomes. in Scientific Reports, 10(1), 17320.
https://doi.org/10.1038/s41598-020-74392-3
Anđelković M, Tadić B, Melnik R. The topology of higher-order complexes associated with brain hubs in human connectomes. in Scientific Reports. 2020;10(1):17320.
doi:10.1038/s41598-020-74392-3 .
Anđelković, Miroslav, Tadić, Bosiljka, Melnik, Roderick, "The topology of higher-order complexes associated with brain hubs in human connectomes" in Scientific Reports, 10, no. 1 (2020):17320,
https://doi.org/10.1038/s41598-020-74392-3 . .
