Changes of Hippocampal Noradrenergic Capacity in Stress Condition
Autori
Gavrilović, LjubicaPopović, Nataša M.
Stojiljković, Vesna
Pejić, Snežana
Todorović, Ana
Pavlović, Ivan
Pajović, Snežana B.
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
This study aimed to investigate the effects of chronic restraint stress (CRS) on the protein levels of dopamine-β-hydroxylase (DBH), noradrenaline transporter (NET), vesicular monoamine transporter 2 (VMAT2) and brain-derived neurotrophic factor (BDNF), as well as the concentration of noradrenaline (NA) in the rat hippocampus. The investigated parameters were quantified by Western blot analyses and ELISA kits. We found that CRS increased the protein levels of DBH by 30 %, VMAT2 by 11 %, BDNF by 11 % and the concentration of NA by 104 %, but decreased the protein levels of NET by 16 % in the hippocampus of chronically stressed rats. The molecular mechanisms by which CRS increased the hippocampal NA level are an important adaptive phenomenon of the noradrenergic system in the stress condition. © 2020 Charles University. All rights reserved.
Ključne reči:
Chronic restraint stress / Hippocampus / Noradrenaline / RatsIzvor:
Folia Biologica (Czech Republic), 2020, 66, 2, 81-84Finansiranje / projekti:
- Ćelijske i molekulske osnove malignih i kardiovaskularnih oboljenja-kliničke implikacije (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-41027)
- Molekularno fiziološki biomonitoring aerobnih organizama zasnovan na određivanju biohemijskih biomarkera oksidacionog stresa (RS-MESTD-Basic Research (BR or ON)-173041)
- Akutni koronarni sindrom: istraživanje vulnerabilnosti (plaka, krvi i miokarda), optimalno lečenje i određivanje prognostičkih faktora (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-41022)
Kolekcije
Institucija/grupa
VinčaTY - JOUR AU - Gavrilović, Ljubica AU - Popović, Nataša M. AU - Stojiljković, Vesna AU - Pejić, Snežana AU - Todorović, Ana AU - Pavlović, Ivan AU - Pajović, Snežana B. PY - 2020 UR - https://vinar.vin.bg.ac.rs/handle/123456789/9617 AB - This study aimed to investigate the effects of chronic restraint stress (CRS) on the protein levels of dopamine-β-hydroxylase (DBH), noradrenaline transporter (NET), vesicular monoamine transporter 2 (VMAT2) and brain-derived neurotrophic factor (BDNF), as well as the concentration of noradrenaline (NA) in the rat hippocampus. The investigated parameters were quantified by Western blot analyses and ELISA kits. We found that CRS increased the protein levels of DBH by 30 %, VMAT2 by 11 %, BDNF by 11 % and the concentration of NA by 104 %, but decreased the protein levels of NET by 16 % in the hippocampus of chronically stressed rats. The molecular mechanisms by which CRS increased the hippocampal NA level are an important adaptive phenomenon of the noradrenergic system in the stress condition. © 2020 Charles University. All rights reserved. T2 - Folia Biologica (Czech Republic) T1 - Changes of Hippocampal Noradrenergic Capacity in Stress Condition VL - 66 IS - 2 SP - 81 EP - 84 UR - https://hdl.handle.net/21.15107/rcub_vinar_9617 ER -
@article{ author = "Gavrilović, Ljubica and Popović, Nataša M. and Stojiljković, Vesna and Pejić, Snežana and Todorović, Ana and Pavlović, Ivan and Pajović, Snežana B.", year = "2020", abstract = "This study aimed to investigate the effects of chronic restraint stress (CRS) on the protein levels of dopamine-β-hydroxylase (DBH), noradrenaline transporter (NET), vesicular monoamine transporter 2 (VMAT2) and brain-derived neurotrophic factor (BDNF), as well as the concentration of noradrenaline (NA) in the rat hippocampus. The investigated parameters were quantified by Western blot analyses and ELISA kits. We found that CRS increased the protein levels of DBH by 30 %, VMAT2 by 11 %, BDNF by 11 % and the concentration of NA by 104 %, but decreased the protein levels of NET by 16 % in the hippocampus of chronically stressed rats. The molecular mechanisms by which CRS increased the hippocampal NA level are an important adaptive phenomenon of the noradrenergic system in the stress condition. © 2020 Charles University. All rights reserved.", journal = "Folia Biologica (Czech Republic)", title = "Changes of Hippocampal Noradrenergic Capacity in Stress Condition", volume = "66", number = "2", pages = "81-84", url = "https://hdl.handle.net/21.15107/rcub_vinar_9617" }
Gavrilović, L., Popović, N. M., Stojiljković, V., Pejić, S., Todorović, A., Pavlović, I.,& Pajović, S. B.. (2020). Changes of Hippocampal Noradrenergic Capacity in Stress Condition. in Folia Biologica (Czech Republic), 66(2), 81-84. https://hdl.handle.net/21.15107/rcub_vinar_9617
Gavrilović L, Popović NM, Stojiljković V, Pejić S, Todorović A, Pavlović I, Pajović SB. Changes of Hippocampal Noradrenergic Capacity in Stress Condition. in Folia Biologica (Czech Republic). 2020;66(2):81-84. https://hdl.handle.net/21.15107/rcub_vinar_9617 .
Gavrilović, Ljubica, Popović, Nataša M., Stojiljković, Vesna, Pejić, Snežana, Todorović, Ana, Pavlović, Ivan, Pajović, Snežana B., "Changes of Hippocampal Noradrenergic Capacity in Stress Condition" in Folia Biologica (Czech Republic), 66, no. 2 (2020):81-84, https://hdl.handle.net/21.15107/rcub_vinar_9617 .