Photoactive and antioxidant nanochitosan dots/biocellulose hydrogels for wound healing treatment
Само за регистроване кориснике
2021
Аутори
Zmejkoski, DanicaMarković, Zoran M.
Budimir, Milica
Zdravković, Nemanja M.
Trišić, Dijana
Bugárová, Nikol
Danko, Martin
Kozyrovska, Natalia O.
Špitalský, Zdeno
Kleinová, Angela
Kuzman, Sanja
Pavlović, Vladimir B.
Todorović-Marković, Biljana
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Bacterial infection and their resistance to known antibiotics delays wound healing. In this study, nanochitosan dots (nChiD) produced by gamma irradiation have been encapsulated in bacterial cellulose (BC) polymer matrix to study the antibacterial potentials of these nanocomposites and their possible usage in wound healing treatment (scratch assay). Detailed analyses show that nChiDs have disc-like shape and average diameter in the range of 40 to 60 nm depending of the applied dose. All nChiDs as well as BC-nChiD nanocomposites emit green photoluminescence independently on the excitation wavelengths. The new designed nanocomposites do not have a cytotoxic effect; antioxidant analysis shows their moderate radical scavenging activity whereas antibacterial properties show significant growth inhibition of strains mostly found in difficult-to-heal wounds. The obtained results confirm that new designed BC-nChiD nanocomposites might be potential agent in wound healing treatment. © 2021 Elsevi...er B.V.
Кључне речи:
Bacterial cellulose / Nanochitosan dots / Nanocomposite / Photoluminescence / Wound healingИзвор:
Materials Science and Engineering: C, 2021, 122, 111925-Финансирање / пројекти:
- Ministry of Education, Science and Technological Development of the Republic of Serbia [451-03-2/2020- 14/20-0302002]
- COST [CA16217] “ENIUS”
- VEGA [2/0051/20]
- Ministry of Education, Science and Technological Development of the Republic of Serbia [TR31079]
DOI: 10.1016/j.msec.2021.111925
ISSN: 0928-4931
PubMed: 33641918
WoS: 000624398400002
Scopus: 2-s2.0-85100684696
Колекције
Институција/група
VinčaTY - JOUR AU - Zmejkoski, Danica AU - Marković, Zoran M. AU - Budimir, Milica AU - Zdravković, Nemanja M. AU - Trišić, Dijana AU - Bugárová, Nikol AU - Danko, Martin AU - Kozyrovska, Natalia O. AU - Špitalský, Zdeno AU - Kleinová, Angela AU - Kuzman, Sanja AU - Pavlović, Vladimir B. AU - Todorović-Marković, Biljana PY - 2021 UR - https://vinar.vin.bg.ac.rs/handle/123456789/9566 AB - Bacterial infection and their resistance to known antibiotics delays wound healing. In this study, nanochitosan dots (nChiD) produced by gamma irradiation have been encapsulated in bacterial cellulose (BC) polymer matrix to study the antibacterial potentials of these nanocomposites and their possible usage in wound healing treatment (scratch assay). Detailed analyses show that nChiDs have disc-like shape and average diameter in the range of 40 to 60 nm depending of the applied dose. All nChiDs as well as BC-nChiD nanocomposites emit green photoluminescence independently on the excitation wavelengths. The new designed nanocomposites do not have a cytotoxic effect; antioxidant analysis shows their moderate radical scavenging activity whereas antibacterial properties show significant growth inhibition of strains mostly found in difficult-to-heal wounds. The obtained results confirm that new designed BC-nChiD nanocomposites might be potential agent in wound healing treatment. © 2021 Elsevier B.V. T2 - Materials Science and Engineering: C T1 - Photoactive and antioxidant nanochitosan dots/biocellulose hydrogels for wound healing treatment VL - 122 SP - 111925 DO - 10.1016/j.msec.2021.111925 ER -
@article{ author = "Zmejkoski, Danica and Marković, Zoran M. and Budimir, Milica and Zdravković, Nemanja M. and Trišić, Dijana and Bugárová, Nikol and Danko, Martin and Kozyrovska, Natalia O. and Špitalský, Zdeno and Kleinová, Angela and Kuzman, Sanja and Pavlović, Vladimir B. and Todorović-Marković, Biljana", year = "2021", abstract = "Bacterial infection and their resistance to known antibiotics delays wound healing. In this study, nanochitosan dots (nChiD) produced by gamma irradiation have been encapsulated in bacterial cellulose (BC) polymer matrix to study the antibacterial potentials of these nanocomposites and their possible usage in wound healing treatment (scratch assay). Detailed analyses show that nChiDs have disc-like shape and average diameter in the range of 40 to 60 nm depending of the applied dose. All nChiDs as well as BC-nChiD nanocomposites emit green photoluminescence independently on the excitation wavelengths. The new designed nanocomposites do not have a cytotoxic effect; antioxidant analysis shows their moderate radical scavenging activity whereas antibacterial properties show significant growth inhibition of strains mostly found in difficult-to-heal wounds. The obtained results confirm that new designed BC-nChiD nanocomposites might be potential agent in wound healing treatment. © 2021 Elsevier B.V.", journal = "Materials Science and Engineering: C", title = "Photoactive and antioxidant nanochitosan dots/biocellulose hydrogels for wound healing treatment", volume = "122", pages = "111925", doi = "10.1016/j.msec.2021.111925" }
Zmejkoski, D., Marković, Z. M., Budimir, M., Zdravković, N. M., Trišić, D., Bugárová, N., Danko, M., Kozyrovska, N. O., Špitalský, Z., Kleinová, A., Kuzman, S., Pavlović, V. B.,& Todorović-Marković, B.. (2021). Photoactive and antioxidant nanochitosan dots/biocellulose hydrogels for wound healing treatment. in Materials Science and Engineering: C, 122, 111925. https://doi.org/10.1016/j.msec.2021.111925
Zmejkoski D, Marković ZM, Budimir M, Zdravković NM, Trišić D, Bugárová N, Danko M, Kozyrovska NO, Špitalský Z, Kleinová A, Kuzman S, Pavlović VB, Todorović-Marković B. Photoactive and antioxidant nanochitosan dots/biocellulose hydrogels for wound healing treatment. in Materials Science and Engineering: C. 2021;122:111925. doi:10.1016/j.msec.2021.111925 .
Zmejkoski, Danica, Marković, Zoran M., Budimir, Milica, Zdravković, Nemanja M., Trišić, Dijana , Bugárová, Nikol, Danko, Martin, Kozyrovska, Natalia O., Špitalský, Zdeno, Kleinová, Angela, Kuzman, Sanja, Pavlović, Vladimir B., Todorović-Marković, Biljana, "Photoactive and antioxidant nanochitosan dots/biocellulose hydrogels for wound healing treatment" in Materials Science and Engineering: C, 122 (2021):111925, https://doi.org/10.1016/j.msec.2021.111925 . .