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Estrogen Receptor Beta: The Promising Biomarker and Potential Target in Metastases

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2021
Main article [PDF] (1.786Mb)
Authors
Božović, Ana M.
Mandušić, Vesna
Todorović, Lidija
Krajnović, Milena M.
Article (Published version)
,
© 2021 The Author(s)
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Abstract
The discovery of the Estrogen Receptor Beta (ERβ) in 1996 opened new perspectives in the diagnostics and therapy of different types of cancer. Here, we present a review of the present research knowledge about its role in endocrine-related cancers: breast, prostate, and thyroid, and colorectal cancers. We also discuss the reasons for the controversy of its role in carcinogenesis and why it is still not in use as a biomarker in clinical practice. Given that the diagnostics and therapy would benefit from the introduction of new biomarkers, we suggest ways to overcome the contradictions in elucidating the role of ERβ.
Keywords:
Biomarker / Carcinogenesis / Endocrine-related cancers / Estrogen Receptor Beta / Isoforms / Metastases / Methylation / Promoters / Tumor-suppressor
Source:
International Journal of Molecular Sciences, 2021, 22, 4, 1656-
Funding / projects:
  • Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 200017 (University of Belgrade, Institute of Nuclear Sciences 'Vinča', Belgrade-Vinča) (RS-200017)
Note:
  • Special Issue "Biomarkers in Hematological and Oncological Malignancies: Identification, Validation and Involvement in Molecular Pathways"

DOI: 10.3390/ijms22041656

ISSN: 1422-0067

PubMed: 33562134

WoS: 000623881500001

Scopus: 2-s2.0-85100504125
[ Google Scholar ]
16
7
URI
https://vinar.vin.bg.ac.rs/handle/123456789/9560
Collections
  • Radovi istraživača
  • 080 - Laboratorija za radiobiologiju i molekularnu genetiku
Institution/Community
Vinča
TY  - JOUR
AU  - Božović, Ana M.
AU  - Mandušić, Vesna
AU  - Todorović, Lidija
AU  - Krajnović, Milena M.
PY  - 2021
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9560
AB  - The discovery of the Estrogen Receptor Beta (ERβ) in 1996 opened new perspectives in the diagnostics and therapy of different types of cancer. Here, we present a review of the present research knowledge about its role in endocrine-related cancers: breast, prostate, and thyroid, and colorectal cancers. We also discuss the reasons for the controversy of its role in carcinogenesis and why it is still not in use as a biomarker in clinical practice. Given that the diagnostics and therapy would benefit from the introduction of new biomarkers, we suggest ways to overcome the contradictions in elucidating the role of ERβ.
T2  - International Journal of Molecular Sciences
T1  - Estrogen Receptor Beta: The Promising Biomarker and Potential Target in Metastases
VL  - 22
IS  - 4
SP  - 1656
DO  - 10.3390/ijms22041656
ER  - 
@article{
author = "Božović, Ana M. and Mandušić, Vesna and Todorović, Lidija and Krajnović, Milena M.",
year = "2021",
abstract = "The discovery of the Estrogen Receptor Beta (ERβ) in 1996 opened new perspectives in the diagnostics and therapy of different types of cancer. Here, we present a review of the present research knowledge about its role in endocrine-related cancers: breast, prostate, and thyroid, and colorectal cancers. We also discuss the reasons for the controversy of its role in carcinogenesis and why it is still not in use as a biomarker in clinical practice. Given that the diagnostics and therapy would benefit from the introduction of new biomarkers, we suggest ways to overcome the contradictions in elucidating the role of ERβ.",
journal = "International Journal of Molecular Sciences",
title = "Estrogen Receptor Beta: The Promising Biomarker and Potential Target in Metastases",
volume = "22",
number = "4",
pages = "1656",
doi = "10.3390/ijms22041656"
}
Božović, A. M., Mandušić, V., Todorović, L.,& Krajnović, M. M.. (2021). Estrogen Receptor Beta: The Promising Biomarker and Potential Target in Metastases. in International Journal of Molecular Sciences, 22(4), 1656.
https://doi.org/10.3390/ijms22041656
Božović AM, Mandušić V, Todorović L, Krajnović MM. Estrogen Receptor Beta: The Promising Biomarker and Potential Target in Metastases. in International Journal of Molecular Sciences. 2021;22(4):1656.
doi:10.3390/ijms22041656 .
Božović, Ana M., Mandušić, Vesna, Todorović, Lidija, Krajnović, Milena M., "Estrogen Receptor Beta: The Promising Biomarker and Potential Target in Metastases" in International Journal of Molecular Sciences, 22, no. 4 (2021):1656,
https://doi.org/10.3390/ijms22041656 . .

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