Mutacije ras-gena u tumorima bešike
Ras gene mutations in bladder tumors
Само за регистроване кориснике
1992
Аутори
Milašin, JelenaDedović, Nasta
Pujić, Natalija
Vranić, Vesna
Mićić, S.
Dimitrijević, Bogomir B.
Diklić, V.
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
DNK, izolovana iz 32 tumora bešike, analizirana je na prisustvo tačkastih mutacija H-ras gena za koji se zna da učestvuje u razvitku različitih malignih tumora čoveka. Primenom tehnike hibridizacije oligonuklotidnim probama na in vitro umnoženu tumorsku DNK, tačkaste mutacije na 12. i 13. kodonu H-ras gena detektovane su u 7 od 32 tumorska uzorka (22%). Ovako niska učestalost mutacija H-ras gena upućuje na zaključak da njihova aktivacija nije dominantni genetski događaj u razvitku tumora bešike, bar ne u većem delu te tumorske populacije.
The DNA from thirty-two bladder cancers was screened for the presence of H-ras gene mutations, known to be involved in the pathogenesis of various human malignancies. Using the technique of oligonucleotide hybridization on previously in vitro amplified tumor DNA, H-ras mutations at codon 12 and 13 were detected in 7 out of 32 tumor specimens (22%). This low incidence of mutated ras genes suggests that their activation does not represent the crucial event in bladder tumor development, at least in the major part of tumor population.
Кључне речи:
karcinom mokraćne bešike / ras onkogeni / mutaciona aktivacija / bladder tumors / ras oncogene / mutational activationИзвор:
Archivum urologicum, 1992, 14, 35/36, 35-40Колекције
Институција/група
VinčaTY - JOUR AU - Milašin, Jelena AU - Dedović, Nasta AU - Pujić, Natalija AU - Vranić, Vesna AU - Mićić, S. AU - Dimitrijević, Bogomir B. AU - Diklić, V. PY - 1992 UR - https://vinar.vin.bg.ac.rs/handle/123456789/9512 AB - DNK, izolovana iz 32 tumora bešike, analizirana je na prisustvo tačkastih mutacija H-ras gena za koji se zna da učestvuje u razvitku različitih malignih tumora čoveka. Primenom tehnike hibridizacije oligonuklotidnim probama na in vitro umnoženu tumorsku DNK, tačkaste mutacije na 12. i 13. kodonu H-ras gena detektovane su u 7 od 32 tumorska uzorka (22%). Ovako niska učestalost mutacija H-ras gena upućuje na zaključak da njihova aktivacija nije dominantni genetski događaj u razvitku tumora bešike, bar ne u većem delu te tumorske populacije. AB - The DNA from thirty-two bladder cancers was screened for the presence of H-ras gene mutations, known to be involved in the pathogenesis of various human malignancies. Using the technique of oligonucleotide hybridization on previously in vitro amplified tumor DNA, H-ras mutations at codon 12 and 13 were detected in 7 out of 32 tumor specimens (22%). This low incidence of mutated ras genes suggests that their activation does not represent the crucial event in bladder tumor development, at least in the major part of tumor population. T2 - Archivum urologicum T1 - Mutacije ras-gena u tumorima bešike T1 - Ras gene mutations in bladder tumors VL - 14 IS - 35/36 SP - 35 EP - 40 UR - https://hdl.handle.net/21.15107/rcub_vinar_9512 ER -
@article{ author = "Milašin, Jelena and Dedović, Nasta and Pujić, Natalija and Vranić, Vesna and Mićić, S. and Dimitrijević, Bogomir B. and Diklić, V.", year = "1992", abstract = "DNK, izolovana iz 32 tumora bešike, analizirana je na prisustvo tačkastih mutacija H-ras gena za koji se zna da učestvuje u razvitku različitih malignih tumora čoveka. Primenom tehnike hibridizacije oligonuklotidnim probama na in vitro umnoženu tumorsku DNK, tačkaste mutacije na 12. i 13. kodonu H-ras gena detektovane su u 7 od 32 tumorska uzorka (22%). Ovako niska učestalost mutacija H-ras gena upućuje na zaključak da njihova aktivacija nije dominantni genetski događaj u razvitku tumora bešike, bar ne u većem delu te tumorske populacije., The DNA from thirty-two bladder cancers was screened for the presence of H-ras gene mutations, known to be involved in the pathogenesis of various human malignancies. Using the technique of oligonucleotide hybridization on previously in vitro amplified tumor DNA, H-ras mutations at codon 12 and 13 were detected in 7 out of 32 tumor specimens (22%). This low incidence of mutated ras genes suggests that their activation does not represent the crucial event in bladder tumor development, at least in the major part of tumor population.", journal = "Archivum urologicum", title = "Mutacije ras-gena u tumorima bešike, Ras gene mutations in bladder tumors", volume = "14", number = "35/36", pages = "35-40", url = "https://hdl.handle.net/21.15107/rcub_vinar_9512" }
Milašin, J., Dedović, N., Pujić, N., Vranić, V., Mićić, S., Dimitrijević, B. B.,& Diklić, V.. (1992). Mutacije ras-gena u tumorima bešike. in Archivum urologicum, 14(35/36), 35-40. https://hdl.handle.net/21.15107/rcub_vinar_9512
Milašin J, Dedović N, Pujić N, Vranić V, Mićić S, Dimitrijević BB, Diklić V. Mutacije ras-gena u tumorima bešike. in Archivum urologicum. 1992;14(35/36):35-40. https://hdl.handle.net/21.15107/rcub_vinar_9512 .
Milašin, Jelena, Dedović, Nasta, Pujić, Natalija, Vranić, Vesna, Mićić, S., Dimitrijević, Bogomir B., Diklić, V., "Mutacije ras-gena u tumorima bešike" in Archivum urologicum, 14, no. 35/36 (1992):35-40, https://hdl.handle.net/21.15107/rcub_vinar_9512 .