99mTc-complex of novel diamine-dioxime ligand
Аутори
Mirković, Marija D.![](/themes/MirageVinar/images/orcid.png)
Vranješ-Đurić, Sanja
![](/themes/MirageVinar/images/orcid.png)
Stanković, Dalibor M.
![](/themes/MirageVinar/images/orcid.png)
Petrović, Đorđe
![](/themes/MirageVinar/images/orcid.png)
Mijin, Dušan Ž.
![](/themes/MirageVinar/images/orcid.png)
Nikolić, Nadežda S.
Конференцијски прилог (Објављена верзија)
![](/themes/MirageVinar//images/creativecommons/arr.png)
Society of Physical Chemists of Serbia
Метаподаци
Приказ свих података о документуАпстракт
Novel diamine-dioxime ligand, 4,7-diaza-3,8-diethyldecane-2,9-dione bis oxime
(LH2), derivative of hexamethyl-propylene amine oxime (HMPAO), was
synthesized in order to develop new brain perfusion imaging agent, based on
99mTc(V) complexes. The 99mTc(V)-d,l-HMPAO complex is well-known
radiopharmaceutical for brain imaging. The structures of the synthesized
compound were characterized by UV-Vis, IR, 1
H NMR and 13C NMR. The
procedure for radiolabeling of diamine-dioxime with 99mTc was developed and
radiolabeling yield of the 99mTc-complex was followed by paper and thin-layer
chromatography. The maximum radiolabeling yield was obtained when the
reactions were carried out at pH~9 within 10 min at room temperature (RT).
Biodistribution studies on rats has shown significant uptake of 99mTc-complex
(2.1% ID), 2 min after injection.
Извор:
Physical chemistry 2012 : 11th international conference on fundamental and applied aspects of physical chemistry, 2012, 2, 585-587Издавач:
- Society of Physical Chemists of Serbia
Напомена:
- Physical chemistry 2012 : 11th international conference on fundamental and applied aspects of physical chemistry; Belgrade (Serbia); 24-28 September 2012
Колекције
Институција/група
VinčaTY - CONF AU - Mirković, Marija D. AU - Vranješ-Đurić, Sanja AU - Stanković, Dalibor M. AU - Petrović, Đorđe AU - Mijin, Dušan Ž. AU - Nikolić, Nadežda S. PY - 2012 UR - https://vinar.vin.bg.ac.rs/handle/123456789/9351 AB - Novel diamine-dioxime ligand, 4,7-diaza-3,8-diethyldecane-2,9-dione bis oxime (LH2), derivative of hexamethyl-propylene amine oxime (HMPAO), was synthesized in order to develop new brain perfusion imaging agent, based on 99mTc(V) complexes. The 99mTc(V)-d,l-HMPAO complex is well-known radiopharmaceutical for brain imaging. The structures of the synthesized compound were characterized by UV-Vis, IR, 1 H NMR and 13C NMR. The procedure for radiolabeling of diamine-dioxime with 99mTc was developed and radiolabeling yield of the 99mTc-complex was followed by paper and thin-layer chromatography. The maximum radiolabeling yield was obtained when the reactions were carried out at pH~9 within 10 min at room temperature (RT). Biodistribution studies on rats has shown significant uptake of 99mTc-complex (2.1% ID), 2 min after injection. PB - Society of Physical Chemists of Serbia C3 - Physical chemistry 2012 : 11th international conference on fundamental and applied aspects of physical chemistry T1 - 99mTc-complex of novel diamine-dioxime ligand VL - 2 SP - 585 EP - 587 UR - https://hdl.handle.net/21.15107/rcub_vinar_9351 ER -
@conference{ author = "Mirković, Marija D. and Vranješ-Đurić, Sanja and Stanković, Dalibor M. and Petrović, Đorđe and Mijin, Dušan Ž. and Nikolić, Nadežda S.", year = "2012", abstract = "Novel diamine-dioxime ligand, 4,7-diaza-3,8-diethyldecane-2,9-dione bis oxime (LH2), derivative of hexamethyl-propylene amine oxime (HMPAO), was synthesized in order to develop new brain perfusion imaging agent, based on 99mTc(V) complexes. The 99mTc(V)-d,l-HMPAO complex is well-known radiopharmaceutical for brain imaging. The structures of the synthesized compound were characterized by UV-Vis, IR, 1 H NMR and 13C NMR. The procedure for radiolabeling of diamine-dioxime with 99mTc was developed and radiolabeling yield of the 99mTc-complex was followed by paper and thin-layer chromatography. The maximum radiolabeling yield was obtained when the reactions were carried out at pH~9 within 10 min at room temperature (RT). Biodistribution studies on rats has shown significant uptake of 99mTc-complex (2.1% ID), 2 min after injection.", publisher = "Society of Physical Chemists of Serbia", journal = "Physical chemistry 2012 : 11th international conference on fundamental and applied aspects of physical chemistry", title = "99mTc-complex of novel diamine-dioxime ligand", volume = "2", pages = "585-587", url = "https://hdl.handle.net/21.15107/rcub_vinar_9351" }
Mirković, M. D., Vranješ-Đurić, S., Stanković, D. M., Petrović, Đ., Mijin, D. Ž.,& Nikolić, N. S.. (2012). 99mTc-complex of novel diamine-dioxime ligand. in Physical chemistry 2012 : 11th international conference on fundamental and applied aspects of physical chemistry Society of Physical Chemists of Serbia., 2, 585-587. https://hdl.handle.net/21.15107/rcub_vinar_9351
Mirković MD, Vranješ-Đurić S, Stanković DM, Petrović Đ, Mijin DŽ, Nikolić NS. 99mTc-complex of novel diamine-dioxime ligand. in Physical chemistry 2012 : 11th international conference on fundamental and applied aspects of physical chemistry. 2012;2:585-587. https://hdl.handle.net/21.15107/rcub_vinar_9351 .
Mirković, Marija D., Vranješ-Đurić, Sanja, Stanković, Dalibor M., Petrović, Đorđe, Mijin, Dušan Ž., Nikolić, Nadežda S., "99mTc-complex of novel diamine-dioxime ligand" in Physical chemistry 2012 : 11th international conference on fundamental and applied aspects of physical chemistry, 2 (2012):585-587, https://hdl.handle.net/21.15107/rcub_vinar_9351 .