Chronic psychosocial isolation alters hsp70/gr and hsp90/gr ratios in response to novel acute stress in rat hypothalamus
2010
Преузимање 🢃
Конференцијски прилог (Објављена верзија)
,
Society of Physical Chemists of Serbia
Метаподаци
Приказ свих података о документуАпстракт
It is known that chronic psychosocial isolation (CPSI) exerts maladaptive effect on the
hypothalamic-pituitary-adrenal (HPA) axis activity. Since the hypothalamus (HT) is a
major driver of the HPA axis activity and since glucocorticoid receptor protein (GR)
mediates HPA axis negative feedback particularly in this structure, we studied the
effect of CPSI by following the expression of GR and its chaperones hsp70 and hsp90
in HT. Our results showed that the ratios of HSPs/GR set by the CPSI were altered in
response to a novel acute stress, which indicated negative CPSI influence on GR
functions in HT.
Извор:
Physical chemistry 2010 : 10th international conference on fundamental and applied aspects of physical chemistry, 2010Издавач:
- Society of Physical Chemists of Serbia
Колекције
Институција/група
VinčaTY - CONF AU - Simić, Iva AU - Đorđević, Ana D. AU - Đorđević, Jelena AU - Mitić, Miloš AU - Radojčić, Marija AU - Adžić, Miroslav PY - 2010 UR - https://vinar.vin.bg.ac.rs/handle/123456789/9323 AB - It is known that chronic psychosocial isolation (CPSI) exerts maladaptive effect on the hypothalamic-pituitary-adrenal (HPA) axis activity. Since the hypothalamus (HT) is a major driver of the HPA axis activity and since glucocorticoid receptor protein (GR) mediates HPA axis negative feedback particularly in this structure, we studied the effect of CPSI by following the expression of GR and its chaperones hsp70 and hsp90 in HT. Our results showed that the ratios of HSPs/GR set by the CPSI were altered in response to a novel acute stress, which indicated negative CPSI influence on GR functions in HT. PB - Society of Physical Chemists of Serbia C3 - Physical chemistry 2010 : 10th international conference on fundamental and applied aspects of physical chemistry T1 - Chronic psychosocial isolation alters hsp70/gr and hsp90/gr ratios in response to novel acute stress in rat hypothalamus UR - https://hdl.handle.net/21.15107/rcub_vinar_9323 ER -
@conference{ author = "Simić, Iva and Đorđević, Ana D. and Đorđević, Jelena and Mitić, Miloš and Radojčić, Marija and Adžić, Miroslav", year = "2010", abstract = "It is known that chronic psychosocial isolation (CPSI) exerts maladaptive effect on the hypothalamic-pituitary-adrenal (HPA) axis activity. Since the hypothalamus (HT) is a major driver of the HPA axis activity and since glucocorticoid receptor protein (GR) mediates HPA axis negative feedback particularly in this structure, we studied the effect of CPSI by following the expression of GR and its chaperones hsp70 and hsp90 in HT. Our results showed that the ratios of HSPs/GR set by the CPSI were altered in response to a novel acute stress, which indicated negative CPSI influence on GR functions in HT.", publisher = "Society of Physical Chemists of Serbia", journal = "Physical chemistry 2010 : 10th international conference on fundamental and applied aspects of physical chemistry", title = "Chronic psychosocial isolation alters hsp70/gr and hsp90/gr ratios in response to novel acute stress in rat hypothalamus", url = "https://hdl.handle.net/21.15107/rcub_vinar_9323" }
Simić, I., Đorđević, A. D., Đorđević, J., Mitić, M., Radojčić, M.,& Adžić, M.. (2010). Chronic psychosocial isolation alters hsp70/gr and hsp90/gr ratios in response to novel acute stress in rat hypothalamus. in Physical chemistry 2010 : 10th international conference on fundamental and applied aspects of physical chemistry Society of Physical Chemists of Serbia.. https://hdl.handle.net/21.15107/rcub_vinar_9323
Simić I, Đorđević AD, Đorđević J, Mitić M, Radojčić M, Adžić M. Chronic psychosocial isolation alters hsp70/gr and hsp90/gr ratios in response to novel acute stress in rat hypothalamus. in Physical chemistry 2010 : 10th international conference on fundamental and applied aspects of physical chemistry. 2010;. https://hdl.handle.net/21.15107/rcub_vinar_9323 .
Simić, Iva, Đorđević, Ana D., Đorđević, Jelena, Mitić, Miloš, Radojčić, Marija, Adžić, Miroslav, "Chronic psychosocial isolation alters hsp70/gr and hsp90/gr ratios in response to novel acute stress in rat hypothalamus" in Physical chemistry 2010 : 10th international conference on fundamental and applied aspects of physical chemistry (2010), https://hdl.handle.net/21.15107/rcub_vinar_9323 .