The in vitroinfluence of five polyoxotungstates containing various central atoms on acetylcholinesterase (AChE) activity was investigated. K6[PV3W9O40] × 3H2O, K6H2[TiW11CoO40] × 13H2O, (NH4)14[NaP5W30O110] × 31H2O, K7[SiV3W9O40] × 10H2O, and K7[Ti2PW10O40] induced the enzyme inhibition in a concentration-dependent manner. Inhibitory power of the investigated compounds was evaluated using IC50values. K7[SiV3W9O40] × 10H2O affected AChE activity with lowest potency (IC50 = 4.80 × 10-4mol/L). K6H2[TiW11CoO40] × 13H2O and K7[Ti2PW10O40] exhibited high affinity toward the enzyme, inducing half-maximuminhibition at micromolar concentrations (1.14 × 10-6and 1.04 × 10-6mol/L, respectively), while the same effect was achieved in the presence of about fifty times higher concentration of K6[PV3W9O40] × 3H2O. Finally, (NH4)14[NaP5W30O110] × 31H2O was foundas the most potent inhibitor of AChE ... activity (IC50 = 6.36 × 10-7mol/L), and consequently the most promising candidate for the treatment of neurological diseases associated with acetylcholine leakage.
Source:
Physical chemistry 2016 : 13th international conference on fundamental and applied aspects of physical chemistry, 2016, 451-454
Physical chemistry 2016 : 13th international conference on fundamental and applied aspects of physical chemistry; Belgrade (Serbia); 26-30 September 2016.
TY - CONF
AU - Čolović, Mirjana B.
AU - Bondžić, Aleksandra M.
AU - Kortz, U.
AU - Vasić, Vesna M.
AU - Krstić, Danijela Z.
PY - 2016
UR - https://vinar.vin.bg.ac.rs/handle/123456789/9208
AB - The in vitroinfluence of five polyoxotungstates containing various central atoms on acetylcholinesterase (AChE) activity was investigated. K6[PV3W9O40] × 3H2O, K6H2[TiW11CoO40] × 13H2O, (NH4)14[NaP5W30O110] × 31H2O, K7[SiV3W9O40] × 10H2O, and K7[Ti2PW10O40] induced the enzyme inhibition in a concentration-dependent manner. Inhibitory power of the investigated compounds was evaluated using IC50values. K7[SiV3W9O40] × 10H2O affected AChE activity with lowest potency (IC50 = 4.80 × 10-4mol/L). K6H2[TiW11CoO40] × 13H2O and K7[Ti2PW10O40] exhibited high affinity toward the enzyme, inducing half-maximuminhibition at micromolar concentrations (1.14 × 10-6and 1.04 × 10-6mol/L, respectively), while the same effect was achieved in the presence of about fifty times higher concentration of K6[PV3W9O40] × 3H2O. Finally, (NH4)14[NaP5W30O110] × 31H2O was foundas the most potent inhibitor of AChE activity (IC50 = 6.36 × 10-7mol/L), and consequently the most promising candidate for the treatment of neurological diseases associated with acetylcholine leakage.
PB - Society of Physical Chemists of Serbia
C3 - Physical chemistry 2016 : 13th international conference on fundamental and applied aspects of physical chemistry
T1 - Modulation of acetylcholinesterase activity induced by polyoxotungstates
SP - 451
EP - 454
UR - https://hdl.handle.net/21.15107/rcub_vinar_9208
ER -
@conference{
author = "Čolović, Mirjana B. and Bondžić, Aleksandra M. and Kortz, U. and Vasić, Vesna M. and Krstić, Danijela Z.",
year = "2016",
abstract = "The in vitroinfluence of five polyoxotungstates containing various central atoms on acetylcholinesterase (AChE) activity was investigated. K6[PV3W9O40] × 3H2O, K6H2[TiW11CoO40] × 13H2O, (NH4)14[NaP5W30O110] × 31H2O, K7[SiV3W9O40] × 10H2O, and K7[Ti2PW10O40] induced the enzyme inhibition in a concentration-dependent manner. Inhibitory power of the investigated compounds was evaluated using IC50values. K7[SiV3W9O40] × 10H2O affected AChE activity with lowest potency (IC50 = 4.80 × 10-4mol/L). K6H2[TiW11CoO40] × 13H2O and K7[Ti2PW10O40] exhibited high affinity toward the enzyme, inducing half-maximuminhibition at micromolar concentrations (1.14 × 10-6and 1.04 × 10-6mol/L, respectively), while the same effect was achieved in the presence of about fifty times higher concentration of K6[PV3W9O40] × 3H2O. Finally, (NH4)14[NaP5W30O110] × 31H2O was foundas the most potent inhibitor of AChE activity (IC50 = 6.36 × 10-7mol/L), and consequently the most promising candidate for the treatment of neurological diseases associated with acetylcholine leakage.",
publisher = "Society of Physical Chemists of Serbia",
journal = "Physical chemistry 2016 : 13th international conference on fundamental and applied aspects of physical chemistry",
title = "Modulation of acetylcholinesterase activity induced by polyoxotungstates",
pages = "451-454",
url = "https://hdl.handle.net/21.15107/rcub_vinar_9208"
}
Čolović, M. B., Bondžić, A. M., Kortz, U., Vasić, V. M.,& Krstić, D. Z.. (2016). Modulation of acetylcholinesterase activity induced by polyoxotungstates. in Physical chemistry 2016 : 13th international conference on fundamental and applied aspects of physical chemistry
Society of Physical Chemists of Serbia., 451-454.
https://hdl.handle.net/21.15107/rcub_vinar_9208
Čolović MB, Bondžić AM, Kortz U, Vasić VM, Krstić DZ. Modulation of acetylcholinesterase activity induced by polyoxotungstates. in Physical chemistry 2016 : 13th international conference on fundamental and applied aspects of physical chemistry. 2016;:451-454.
https://hdl.handle.net/21.15107/rcub_vinar_9208 .
Čolović, Mirjana B., Bondžić, Aleksandra M., Kortz, U., Vasić, Vesna M., Krstić, Danijela Z., "Modulation of acetylcholinesterase activity induced by polyoxotungstates" in Physical chemistry 2016 : 13th international conference on fundamental and applied aspects of physical chemistry (2016):451-454,
https://hdl.handle.net/21.15107/rcub_vinar_9208 .
,