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dc.creatorZmejkoski, Danica
dc.creatorMarković, Zoran M.
dc.creatorZdravković, Nemanja M.
dc.creatorTrišić, Dijana D.
dc.creatorBudimir, Milica
dc.creatorKuzman, Sanja
dc.creatorKozyrovska, Natalia O.
dc.creatorOrlovska, Iryna V.
dc.creatorBugárová, Nikol
dc.creatorPetrović, Đorđe
dc.creatorKováčová, Mária
dc.creatorKleinová, Angela
dc.creatorŠpitalský, Zdeno
dc.creatorPavlović, Vladimir B.
dc.creatorTodorović-Marković, Biljana
dc.date.accessioned2021-05-20T08:31:37Z
dc.date.available2021-05-20T08:31:37Z
dc.date.issued2021
dc.identifier.issn2046-2069
dc.identifier.urihttps://vinar.vin.bg.ac.rs/handle/123456789/9143
dc.description.abstractTherapy of bacterial urinary tract infections (UTIs) and catheter associated urinary tract infections (CAUTIs) is still a great challenge because of the resistance of bacteria to nowadays used antibiotics and encrustation of catheters. Bacterial cellulose (BC) as a biocompatible material with a high porosity allows incorporation of different materials in its three dimensional network structure. In this work a low molecular weight chitosan (Chi) polymer is incorporated in BC with different concentrations. Different characterization techniques are used to investigate structural and optical properties of these composites. Radical scavenging activity test shows moderate antioxidant activity of these biocompatible composites whereasin vitrorelease test shows that 13.3% of chitosan is released after 72 h. Antibacterial testing of BC-Chi composites conducted on Gram-positive and Gram-negative bacteria causing UTIs and CAUTIs (Escherichia coli,Pseudomonas aeruginosa,Klebsiella pneumoniae) and encrustation (Proteus mirabilis) show bactericidal effect. The morphology analysis of bacteria after the application of BC-Chi shows that they are flattened with a rough surface, with a tendency to agglomerate and with decreased length and width. All obtained results show that BC-Chi composites might be considered as potential biomedical agents in treatment of UTIs and CAUTIs and as a urinary catheter coating in encrustation prevention.en
dc.language.isoen
dc.relationinfo:eu-repo/grantAgreement/MESTD/Technological Development (TD or TR)/31079/RS//
dc.relationMinistry of Education, Science and Technological Development of the Republic of Serbia [451-03-2/2020-14/20-0302002]
dc.relationCOST Action [CA16217, ENIUS]
dc.relationVEGA [2/0051/20]
dc.rightsopenAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/
dc.sourceRSC Advances
dc.titleBactericidal and antioxidant bacterial cellulose hydrogels doped with chitosan as potential urinary tract infection biomedical agenten
dc.typearticleen
dc.rights.licenseBY-NC
dcterms.abstractКузман, Сања Б.; Будимир, Милица Д.; Тришић, Дијана Д.; Здравковић, Немања М.; Змејкоски, Даница З.; Бугáровá, Никол; Тодоровић-Марковић, Биљана; Клеиновá, Aнгела; Шпиталскý, Здено; Петровић, Ђорђе Ж.; Орловска, Ирyна В.; Марковић, Зоран М.; Козyровска, Наталиа О.; Ковáчовá, Мáриа; Павловић, Владимир Б.;
dc.rights.holder© The Royal Society of Chemistry 2021.
dc.citation.volume11
dc.citation.issue15
dc.citation.spage8559
dc.citation.epage8568
dc.identifier.doi10.1039/D0RA10782D
dc.type.versionpublishedVersion
dc.identifier.scopus2-s2.0-85101859869
dc.identifier.fulltexthttp://vinar.vin.bg.ac.rs/bitstream/id/23012/d0ra10782d.pdf


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