Bactericidal and antioxidant bacterial cellulose hydrogels doped with chitosan as potential urinary tract infection biomedical agent
Аутори
Zmejkoski, DanicaMarković, Zoran M.
Zdravković, Nemanja M.
Trišić, Dijana
Budimir, Milica
Kuzman, Sanja
Kozyrovska, Natalia O.
Orlovska, Iryna V.
Bugárová, Nikol
Petrović, Đorđe
Kováčová, Mária
Kleinová, Angela
Špitalský, Zdeno
Pavlović, Vladimir B.
Todorović-Marković, Biljana
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Therapy of bacterial urinary tract infections (UTIs) and catheter associated urinary tract infections (CAUTIs) is still a great challenge because of the resistance of bacteria to nowadays used antibiotics and encrustation of catheters. Bacterial cellulose (BC) as a biocompatible material with a high porosity allows incorporation of different materials in its three dimensional network structure. In this work a low molecular weight chitosan (Chi) polymer is incorporated in BC with different concentrations. Different characterization techniques are used to investigate structural and optical properties of these composites. Radical scavenging activity test shows moderate antioxidant activity of these biocompatible composites whereasin vitrorelease test shows that 13.3% of chitosan is released after 72 h. Antibacterial testing of BC-Chi composites conducted on Gram-positive and Gram-negative bacteria causing UTIs and CAUTIs (Escherichia coli,Pseudomonas aeruginosa,Klebsiella pneumoniae) and ...encrustation (Proteus mirabilis) show bactericidal effect. The morphology analysis of bacteria after the application of BC-Chi shows that they are flattened with a rough surface, with a tendency to agglomerate and with decreased length and width. All obtained results show that BC-Chi composites might be considered as potential biomedical agents in treatment of UTIs and CAUTIs and as a urinary catheter coating in encrustation prevention.
Извор:
RSC Advances, 2021, 11, 15, 8559-8568Финансирање / пројекти:
- Увођење и евалуација нове молекуларне методе за брзо откривање mecA гена стафилокока директно у брисевима узетим од људи, животиња и из њиховог окружења (RS-31079)
- Ministry of Education, Science and Technological Development of the Republic of Serbia [451-03-2/2020-14/20-0302002]
- COST Action [CA16217, ENIUS]
- VEGA [2/0051/20]
DOI: 10.1039/D0RA10782D
ISSN: 2046-2069
WoS: 000623512700018
Scopus: 2-s2.0-85101859869
Колекције
Институција/група
VinčaTY - JOUR AU - Zmejkoski, Danica AU - Marković, Zoran M. AU - Zdravković, Nemanja M. AU - Trišić, Dijana AU - Budimir, Milica AU - Kuzman, Sanja AU - Kozyrovska, Natalia O. AU - Orlovska, Iryna V. AU - Bugárová, Nikol AU - Petrović, Đorđe AU - Kováčová, Mária AU - Kleinová, Angela AU - Špitalský, Zdeno AU - Pavlović, Vladimir B. AU - Todorović-Marković, Biljana PY - 2021 UR - https://vinar.vin.bg.ac.rs/handle/123456789/9143 AB - Therapy of bacterial urinary tract infections (UTIs) and catheter associated urinary tract infections (CAUTIs) is still a great challenge because of the resistance of bacteria to nowadays used antibiotics and encrustation of catheters. Bacterial cellulose (BC) as a biocompatible material with a high porosity allows incorporation of different materials in its three dimensional network structure. In this work a low molecular weight chitosan (Chi) polymer is incorporated in BC with different concentrations. Different characterization techniques are used to investigate structural and optical properties of these composites. Radical scavenging activity test shows moderate antioxidant activity of these biocompatible composites whereasin vitrorelease test shows that 13.3% of chitosan is released after 72 h. Antibacterial testing of BC-Chi composites conducted on Gram-positive and Gram-negative bacteria causing UTIs and CAUTIs (Escherichia coli,Pseudomonas aeruginosa,Klebsiella pneumoniae) and encrustation (Proteus mirabilis) show bactericidal effect. The morphology analysis of bacteria after the application of BC-Chi shows that they are flattened with a rough surface, with a tendency to agglomerate and with decreased length and width. All obtained results show that BC-Chi composites might be considered as potential biomedical agents in treatment of UTIs and CAUTIs and as a urinary catheter coating in encrustation prevention. T2 - RSC Advances T1 - Bactericidal and antioxidant bacterial cellulose hydrogels doped with chitosan as potential urinary tract infection biomedical agent VL - 11 IS - 15 SP - 8559 EP - 8568 DO - 10.1039/D0RA10782D ER -
@article{ author = "Zmejkoski, Danica and Marković, Zoran M. and Zdravković, Nemanja M. and Trišić, Dijana and Budimir, Milica and Kuzman, Sanja and Kozyrovska, Natalia O. and Orlovska, Iryna V. and Bugárová, Nikol and Petrović, Đorđe and Kováčová, Mária and Kleinová, Angela and Špitalský, Zdeno and Pavlović, Vladimir B. and Todorović-Marković, Biljana", year = "2021", abstract = "Therapy of bacterial urinary tract infections (UTIs) and catheter associated urinary tract infections (CAUTIs) is still a great challenge because of the resistance of bacteria to nowadays used antibiotics and encrustation of catheters. Bacterial cellulose (BC) as a biocompatible material with a high porosity allows incorporation of different materials in its three dimensional network structure. In this work a low molecular weight chitosan (Chi) polymer is incorporated in BC with different concentrations. Different characterization techniques are used to investigate structural and optical properties of these composites. Radical scavenging activity test shows moderate antioxidant activity of these biocompatible composites whereasin vitrorelease test shows that 13.3% of chitosan is released after 72 h. Antibacterial testing of BC-Chi composites conducted on Gram-positive and Gram-negative bacteria causing UTIs and CAUTIs (Escherichia coli,Pseudomonas aeruginosa,Klebsiella pneumoniae) and encrustation (Proteus mirabilis) show bactericidal effect. The morphology analysis of bacteria after the application of BC-Chi shows that they are flattened with a rough surface, with a tendency to agglomerate and with decreased length and width. All obtained results show that BC-Chi composites might be considered as potential biomedical agents in treatment of UTIs and CAUTIs and as a urinary catheter coating in encrustation prevention.", journal = "RSC Advances", title = "Bactericidal and antioxidant bacterial cellulose hydrogels doped with chitosan as potential urinary tract infection biomedical agent", volume = "11", number = "15", pages = "8559-8568", doi = "10.1039/D0RA10782D" }
Zmejkoski, D., Marković, Z. M., Zdravković, N. M., Trišić, D., Budimir, M., Kuzman, S., Kozyrovska, N. O., Orlovska, I. V., Bugárová, N., Petrović, Đ., Kováčová, M., Kleinová, A., Špitalský, Z., Pavlović, V. B.,& Todorović-Marković, B.. (2021). Bactericidal and antioxidant bacterial cellulose hydrogels doped with chitosan as potential urinary tract infection biomedical agent. in RSC Advances, 11(15), 8559-8568. https://doi.org/10.1039/D0RA10782D
Zmejkoski D, Marković ZM, Zdravković NM, Trišić D, Budimir M, Kuzman S, Kozyrovska NO, Orlovska IV, Bugárová N, Petrović Đ, Kováčová M, Kleinová A, Špitalský Z, Pavlović VB, Todorović-Marković B. Bactericidal and antioxidant bacterial cellulose hydrogels doped with chitosan as potential urinary tract infection biomedical agent. in RSC Advances. 2021;11(15):8559-8568. doi:10.1039/D0RA10782D .
Zmejkoski, Danica, Marković, Zoran M., Zdravković, Nemanja M., Trišić, Dijana, Budimir, Milica, Kuzman, Sanja, Kozyrovska, Natalia O., Orlovska, Iryna V., Bugárová, Nikol, Petrović, Đorđe, Kováčová, Mária, Kleinová, Angela, Špitalský, Zdeno, Pavlović, Vladimir B., Todorović-Marković, Biljana, "Bactericidal and antioxidant bacterial cellulose hydrogels doped with chitosan as potential urinary tract infection biomedical agent" in RSC Advances, 11, no. 15 (2021):8559-8568, https://doi.org/10.1039/D0RA10782D . .