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dc.creatorDugalić, Predrag
dc.creatorĐuranović, Srđan
dc.creatorPavlović-Marković, Aleksandra
dc.creatorDugalić, Vladimir
dc.creatorTomašević, Ratko
dc.creatorGluvić, Zoran
dc.creatorObradović, Milan M.
dc.creatorBajić, Vladan P.
dc.creatorIsenović, Esma R.
dc.date.accessioned2021-04-15T10:46:40Z
dc.date.available2021-04-15T10:46:40Z
dc.date.issued2020
dc.identifier.issn1389-5575
dc.identifier.urihttps://vinar.vin.bg.ac.rs/handle/123456789/9104
dc.description.abstractGastroesophageal Reflux Disease (GERD) is characterized by acid and bile reflux in the dis-tal oesophagus, and this may cause the development of reflux esophagitis and Barrett’s oesophagus (BE). The natural histological course of untreated BE is non-dysplastic or benign BE (ND), then low-grade (LGD) and High-Grade Dysplastic (HGD) BE, with the expected increase in malignancy transfer to oesophagal adenocarcinoma (EAC). The gold standard for BE diagnostics involves high-resolution white-light endoscopy, followed by uniform endoscopy findings description (Prague classification) with biopsy performance according to Seattle protocol. The medical treatment of GERD and BE includes the use of proton pump inhibitors (PPIs) regarding symptoms control. It is noteworthy that long-term use of PPIs increases gastrin level, which can contribute to transfer from BE to EAC, as a result of its effects on the proliferation of BE epithelium. Endoscopy treatment includes a wide range of re-section and ablative techniques, such as radio-frequency ablation (RFA), often concomitantly used in everyday endoscopy practice (multimodal therapy). RFA promotes mucosal necrosis of treated oesophagal region via high-frequency energy. Laparoscopic surgery, partial or total fundoplication, is reserved for PPIs and endoscopy indolent patients or in those with progressive disease. This review aims to explain distinct effects of PPIs and RFA modalities, illuminate certain aspects of molecular mechanisms involved, as well as the effects of their concomitant use regarding the treatment of BE and prevention of its transfer to EAC.en
dc.language.isoen
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173033/RS//
dc.rightsrestrictedAccess
dc.sourceMini-Reviews in Medicinal Chemistry
dc.subjectGERDen
dc.subjectBarrett's oesophagusen
dc.subjectproton pump inhibitorsen
dc.subjectradio-frequency ablationen
dc.subjectaction of PPIsen
dc.subjectoesophagusen
dc.titleProton Pump Inhibitors and Radiofrequency Ablation for Treatment of Barrett's Esophagusen
dc.typearticleen
dc.rights.licenseARR
dcterms.abstractОбрадовић, Милан; Бајић, Владан; Павловић-Марковић, Aлександра; Ђурановић, Срђан; Дугалић, Предраг; Исеновић, Есма Р.; Глувић, Зоран; Дугалић, Владимир; Томашевић, Ратко;
dc.rights.holder© 2020 Bentham Science Publishers
dc.citation.volume20
dc.citation.issue11
dc.citation.spage975
dc.citation.epage987
dc.identifier.wos000551675400003
dc.identifier.doi10.2174/1389557519666191015203636
dc.identifier.pmid31644405
dc.type.versionpublishedVersion
dc.identifier.scopus2-s2.0-85088276768


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