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dc.creatorSatarić, Miljko V.
dc.creatorNemeš, Tomas
dc.creatorSatarić, Bogdan
dc.creatorSekulić, Dalibor
dc.creatorZdravković, Slobodan
dc.date.accessioned2021-04-05T10:02:19Z
dc.date.available2021-04-05T10:02:19Z
dc.date.issued2020
dc.identifier.issn0303-2647
dc.identifier.urihttps://vinar.vin.bg.ac.rs/handle/123456789/9059
dc.description.abstractThe cytoskeleton of cilia and flagella is so called axoneme a stable cylindrical architecture of nine microtubule doublets. Axoneme performs periodic bending motion by utilizing specific dynein motor family powered by ATP hydrolysis. It is still unclear how this highly organized “ciliary beat” is being initiated and strongly coordinated by the combined action of hundreds dynein motors. Based on the experimental evidences we here elaborate a plausible scenario in which actually calcium ions play the roles of catalytic activators and coordinators of dynein attachments doing it in superposition with already known mechanical control tools of “ciliary beat”. Polyelectrolyte properties of microtubules incorporated in axoneme doublets enable the formation and propagation of soliton-like “ionic clouds” of Ca2+ ions along these “coaxial nanocables”. The sliding speed of such Ca2+ “clouds” along microtubule doublets is comparable with the speed of propagation of “ciliary beat” itself. We elaborated the interplay between influx of Ca2+ ions in ciliary based body and the sliding of microtubule triplets therein. In second segment we considered how the dynein motors activated by Ca2+ ions contained within solitonic “ionic clouds” in competition with axoneme curvature regulate ciliary and flagellar beating.en
dc.language.isoen
dc.relationProvincial Secretariat for Higher Education and Scientific Research of AP Vojvodina [1144512708/201603]
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/171009/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/43008/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/45010/RS//
dc.relationSerbian Academy of Sciences and Arts
dc.rightsrestrictedAccess
dc.sourceBiosystems
dc.subjectMicrotubuleen
dc.subjectAxonemeen
dc.subjectNonlinear electric transmission lineen
dc.subjectIonic clouden
dc.titleCalcium ions tune the beats of cilia and flagellaen
dc.typearticleen
dc.rights.licenseARR
dcterms.abstractСатарић, Миљко В.; Здравковић, Слободан; Немеш, Томас; Сатарић, Богдан; Секулић, Далибор;
dc.rights.holder© 2020 Elsevier B.V.
dc.citation.volume196
dc.citation.spage104172
dc.identifier.wos000564562900003
dc.identifier.doi10.1016/j.biosystems.2020.104172
dc.identifier.pmid32534169
dc.type.versionpublishedVersion
dc.identifier.scopus2-s2.0-85086886772


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