Biocompatibility of TiO2 prolate nanospheroids as a potential photosenzitizer in therapy of cancer
Samo za registrovane korisnike
2020
Autori
Matijević, MilicaNakarada, Đura
Liang, Xinyue
Korićanac, Lela
Rajsiglova, Lenka
Vannucci, Luca
Nešić, Maja D.
Vranješ, Mila
Mojović, Miloš D.
Mi, Lan
Estrela-Lopis, Irina
Böttner, Julia
Šaponjić, Zoran
Petković, Marijana
Stepić, Milutin
Članak u časopisu (Objavljena verzija)
,
© 2020, Springer Nature B.V.
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
TiO2 prolatenanospheroids (PNSs) may be photosensitizers (PSs), which act by catalyzation of hydroxyl radical (∙OH) formation upon light illumination. ∙OH might, in turn, contribute to killing of cancer cells. On the other hand, there is great concern about toxicity in the dark of TiO2 nanoparticles in general. In this work, we have investigated the biocompatibility of TiO2 PNSs of the anatase crystal form (length between 100 and 300 nm and width 50 nm) in the dark with immune cells and light-induced cytotoxicity on several cancer cell lines. The effects of the treatment of different cell lines with several concentrations of TiO2 PNSs suspensions showed the specifics of cells’ viability and the intracellular localization. The results of in vitro studies obtained by cytotoxicity assays adjusted to individual cell lines’ metabolism point towards the biocompatibility of TiO2 PNSs at low and moderate concentrations in the dark, which neither kill the cells, nor induce activation of the imm...une system cells. Laser scanning confocal microscopy revealed that PNSs are taken up by cells, and insight into the intracellular distribution was obtained in this study.
Ključne reči:
TiO(2)prolate nanospheroids / Photodynamic therapy / Cancer therapy / Oxidative activity / NanomedicineIzvor:
Journal of Nanoparticle Research, 2020, 22, 7, 175-Finansiranje / projekti:
- Ispitivanje mehanizma reakcija kompleksa jona prelaznih metala sa biološki značajnim molekulima (RS-MESTD-Basic Research (BR or ON)-172011)
- Uticaj veličine, oblika i strukture nanočestica na njihova svojstva i svojstva nanokompozita (RS-MESTD-Basic Research (BR or ON)-172056)
- Fotonika mikro i nano strukturnih materijala (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-45010)
- Biomarkeri u neurodegenerativnim i malignim procesima (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-41005)
- Ćelijske i molekulske osnove malignih i kardiovaskularnih oboljenja-kliničke implikacije (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-41027)
- Danube Region Strategies multilateral project -Danube meets Omics [DS 052]
- Bilateral project Republic of Serbia-People's Republic of China [451-00-478/2018-09/16]
DOI: 10.1007/s11051-020-04899-3
ISSN: 1388-0764
WoS: 000547506100001
Scopus: 2-s2.0-85087054250
Kolekcije
Institucija/grupa
VinčaTY - JOUR AU - Matijević, Milica AU - Nakarada, Đura AU - Liang, Xinyue AU - Korićanac, Lela AU - Rajsiglova, Lenka AU - Vannucci, Luca AU - Nešić, Maja D. AU - Vranješ, Mila AU - Mojović, Miloš D. AU - Mi, Lan AU - Estrela-Lopis, Irina AU - Böttner, Julia AU - Šaponjić, Zoran AU - Petković, Marijana AU - Stepić, Milutin PY - 2020 UR - https://vinar.vin.bg.ac.rs/handle/123456789/9058 AB - TiO2 prolatenanospheroids (PNSs) may be photosensitizers (PSs), which act by catalyzation of hydroxyl radical (∙OH) formation upon light illumination. ∙OH might, in turn, contribute to killing of cancer cells. On the other hand, there is great concern about toxicity in the dark of TiO2 nanoparticles in general. In this work, we have investigated the biocompatibility of TiO2 PNSs of the anatase crystal form (length between 100 and 300 nm and width 50 nm) in the dark with immune cells and light-induced cytotoxicity on several cancer cell lines. The effects of the treatment of different cell lines with several concentrations of TiO2 PNSs suspensions showed the specifics of cells’ viability and the intracellular localization. The results of in vitro studies obtained by cytotoxicity assays adjusted to individual cell lines’ metabolism point towards the biocompatibility of TiO2 PNSs at low and moderate concentrations in the dark, which neither kill the cells, nor induce activation of the immune system cells. Laser scanning confocal microscopy revealed that PNSs are taken up by cells, and insight into the intracellular distribution was obtained in this study. T2 - Journal of Nanoparticle Research T1 - Biocompatibility of TiO2 prolate nanospheroids as a potential photosenzitizer in therapy of cancer VL - 22 IS - 7 SP - 175 DO - 10.1007/s11051-020-04899-3 ER -
@article{ author = "Matijević, Milica and Nakarada, Đura and Liang, Xinyue and Korićanac, Lela and Rajsiglova, Lenka and Vannucci, Luca and Nešić, Maja D. and Vranješ, Mila and Mojović, Miloš D. and Mi, Lan and Estrela-Lopis, Irina and Böttner, Julia and Šaponjić, Zoran and Petković, Marijana and Stepić, Milutin", year = "2020", abstract = "TiO2 prolatenanospheroids (PNSs) may be photosensitizers (PSs), which act by catalyzation of hydroxyl radical (∙OH) formation upon light illumination. ∙OH might, in turn, contribute to killing of cancer cells. On the other hand, there is great concern about toxicity in the dark of TiO2 nanoparticles in general. In this work, we have investigated the biocompatibility of TiO2 PNSs of the anatase crystal form (length between 100 and 300 nm and width 50 nm) in the dark with immune cells and light-induced cytotoxicity on several cancer cell lines. The effects of the treatment of different cell lines with several concentrations of TiO2 PNSs suspensions showed the specifics of cells’ viability and the intracellular localization. The results of in vitro studies obtained by cytotoxicity assays adjusted to individual cell lines’ metabolism point towards the biocompatibility of TiO2 PNSs at low and moderate concentrations in the dark, which neither kill the cells, nor induce activation of the immune system cells. Laser scanning confocal microscopy revealed that PNSs are taken up by cells, and insight into the intracellular distribution was obtained in this study.", journal = "Journal of Nanoparticle Research", title = "Biocompatibility of TiO2 prolate nanospheroids as a potential photosenzitizer in therapy of cancer", volume = "22", number = "7", pages = "175", doi = "10.1007/s11051-020-04899-3" }
Matijević, M., Nakarada, Đ., Liang, X., Korićanac, L., Rajsiglova, L., Vannucci, L., Nešić, M. D., Vranješ, M., Mojović, M. D., Mi, L., Estrela-Lopis, I., Böttner, J., Šaponjić, Z., Petković, M.,& Stepić, M.. (2020). Biocompatibility of TiO2 prolate nanospheroids as a potential photosenzitizer in therapy of cancer. in Journal of Nanoparticle Research, 22(7), 175. https://doi.org/10.1007/s11051-020-04899-3
Matijević M, Nakarada Đ, Liang X, Korićanac L, Rajsiglova L, Vannucci L, Nešić MD, Vranješ M, Mojović MD, Mi L, Estrela-Lopis I, Böttner J, Šaponjić Z, Petković M, Stepić M. Biocompatibility of TiO2 prolate nanospheroids as a potential photosenzitizer in therapy of cancer. in Journal of Nanoparticle Research. 2020;22(7):175. doi:10.1007/s11051-020-04899-3 .
Matijević, Milica, Nakarada, Đura, Liang, Xinyue, Korićanac, Lela, Rajsiglova, Lenka, Vannucci, Luca, Nešić, Maja D., Vranješ, Mila, Mojović, Miloš D., Mi, Lan, Estrela-Lopis, Irina, Böttner, Julia, Šaponjić, Zoran, Petković, Marijana, Stepić, Milutin, "Biocompatibility of TiO2 prolate nanospheroids as a potential photosenzitizer in therapy of cancer" in Journal of Nanoparticle Research, 22, no. 7 (2020):175, https://doi.org/10.1007/s11051-020-04899-3 . .