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dc.creatorVan Gool, Alain
dc.creatorCorrales, Fernado
dc.creatorČolović, Mirjana B.
dc.creatorKrstić, Danijela
dc.creatorOliver-Martos, Begona
dc.creatorMartínez-Cáceres, Eva
dc.creatorJakasa, Ivone
dc.creatorGajski, Goran
dc.creatorBrun, Virginie
dc.creatorKyriacou, Kyriacos
dc.creatorBurzynska-Pedziwiatr, Izabela
dc.creatorWozniak, Lucyna Alicja
dc.creatorNierkens, Stephan
dc.creatorPascual García, César
dc.creatorKatrlik, Jaroslav
dc.creatorBojić-Trbojević, Žanka
dc.creatorVacek, Jan
dc.creatorLlorente, Alicia
dc.creatorAntohe, Felicia
dc.creatorSuica, Viorel
dc.creatorSuarez, Guillaume
dc.creatorT’Kindt, Ruben
dc.creatorMartin, Petra
dc.creatorPenque, Deborah
dc.creatorMartins, Ines Lanca
dc.creatorBodoki, Ede
dc.creatorIacob, Bogdan-Cezar
dc.creatorAydindogan, Eda
dc.creatorTimur, Suna
dc.creatorAllinson, John
dc.creatorSutton, Christopher
dc.creatorLuider, Theo
dc.creatorWittfooth, Saara
dc.creatorSammar, Marei
dc.date.accessioned2021-03-05T13:01:45Z
dc.date.available2021-03-05T13:01:45Z
dc.date.issued2020
dc.identifier.issn1478-9450
dc.identifier.urihttps://vinar.vin.bg.ac.rs/handle/123456789/9018
dc.description.abstractIntroduction: The importance of biomarkers for pharmaceutical drug development and clinical diagnostics is more significant than ever in the current shift toward personalized medicine. Biomarkers have taken a central position either as companion markers to support drug development and patient selection, or as indicators aiming to detect the earliest perturbations indicative of disease, minimizing therapeutic intervention or even enabling disease reversal. Protein biomarkers are of particular interest given their central role in biochemical pathways. Hence, capabilities to analyze multiple protein biomarkers in one assay are highly interesting for biomedical research. Areas covered: We here review multiple methods that are suitable for robust, high throughput, standardized, and affordable analysis of protein biomarkers in a multiplex format. We describe innovative developments in immunoassays, the vanguard of methods in clinical laboratories, and mass spectrometry, increasingly implemented for protein biomarker analysis. Moreover, emerging techniques are discussed with potentially improved protein capture, separation, and detection that will further boost multiplex analyses. Expert commentary: The development of clinically applied multiplex protein biomarker assays is essential as multi-protein signatures provide more comprehensive information about biological systems than single biomarkers, leading to improved insights in mechanisms of disease, diagnostics, and the effect of personalized medicine.en
dc.language.isoen
dc.relationCOST Action [CA16113]
dc.rightsopenAccess
dc.sourceExpert Review of Proteomics
dc.subjectmultiplexingen
dc.subjectmass spectrometryen
dc.subjectvalidationen
dc.titleAnalytical techniques for multiplex analysis of protein biomarkersen
dc.typereviewen
dc.rights.licenseBY-NC-ND
dcterms.abstractКрстић, Данијела; Чоловић, Мирјана; Бојић-Трбојевић, Жанка; Вацек, Јан; Ллоренте, Aлициа; Aнтохе, Фелициа; Суица, Виорел; Суарез, Гуиллауме; Т’Киндт, Рубен; Мартин, Петра; Цорралес, Фернадо; Јакаса, Ивоне; Гајски, Горан; Брун, Виргиние; Кyриацоу, Кyриацос; Ван Гоол, Aлаин; Катрлик, Јарослав; Оливер-Мартос, Бегона; Пенqуе, Деборах; Мартинс, Инес Ланца; Бодоки, Еде; Иацоб, Богдан-Цезар; Ayдиндоган, Еда; Тимур, Суна; Aллинсон, Јохн; Суттон, Цхристопхер; Луидер, Тхео; Wиттфоотх, Саара; Саммар, Мареи; Мартíнез-Цáцерес, Ева; Бурзyнска-Педзиwиатр, Изабела; Wозниак, Луцyна Aлицја; Ниеркенс, Степхан; Пасцуал Гарцíа, Цéсар;
dc.rights.holder© 2020 The Author(s)
dc.citation.volume17
dc.citation.issue4
dc.citation.spage257
dc.citation.epage273
dc.identifier.wos000536384300001
dc.identifier.doi10.1080/14789450.2020.1763174
dc.identifier.pmid32427033
dc.type.versionpublishedVersion
dc.identifier.scopus2-s2.0-85085325196
dc.identifier.fulltexthttp://vinar.vin.bg.ac.rs/bitstream/id/22625/bitstream_22625.pdf


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