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dc.creatorKeta, Otilija D.
dc.creatorDeljanin, Milena
dc.creatorPetković, Vladana
dc.creatorZdunić, Gordana
dc.creatorJanković, Teodora
dc.creatorŽivković, Jelena
dc.creatorRistić-Fira, Aleksandra
dc.creatorPetrović, Ivan M.
dc.creatorŠavikin, Katarina
dc.date.accessioned2021-03-02T08:55:34Z
dc.date.available2021-03-02T08:55:34Z
dc.date.issued2020
dc.identifier.issn1307-6167
dc.identifier.urihttps://vinar.vin.bg.ac.rs/handle/123456789/8996
dc.description.abstractThe aim of the present study was to investigate effects of pomegranate peel (PP) extract on different human cancer cell lines. MTT was performed to estimate cytotoxic effects of PP extract against HTB140, HTB177, MCF7, HCT116 human cancer cell lines and MRC-5 normal fibroblasts. Clonogenic assay was used to reveal cell survival after the treatment with PP extract. Cell cycle analysis was done using flow cytometry. Wound healing assay was applied to estimate inhibitory effects of PP extract on migration of cancer cells. The results showed that PP extract expressed selective cytotoxicity for cancer cells compared to normal cell line. Analyzed cancer cell lines displayed individual variations in sensitivity to PP extract reflected through changes in clonogenic survival, cell cycle distribution and migration, which may be due to the specific nature of each tested cell line. In conclusion, PP extract exhibits good inhibitory effects on tested cancer cell lines.en
dc.language.isoen
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/46013/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173046/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/171019/RS//
dc.rightsopenAccess
dc.sourceRecords of Natural Products
dc.subjectPunica granatum L.en
dc.subjectpeel extracten
dc.subjectphenolic compoundsen
dc.subjectcytotoxicityen
dc.subjectcancer cellsen
dc.titlePomegranate (Punica granatum L.) Peel Extract: Potential Cytotoxic Agent Against Different Cancer Cell Linesen
dc.typearticleen
dc.rights.licenseARR
dcterms.abstractЖивковић, Јелена; Дељанин, Милена; Шавикин, Катарина; Петровић, Иван М.; Јанковић, Теодора; Здунић, Гордана; Кета, Отилија Д.; Ристић-Фира, Aлександра; Петковић, Владана;
dc.rights.holder© 2020 ACG Publications
dc.citation.volume14
dc.citation.issue5
dc.citation.spage326
dc.citation.epage339
dc.identifier.wos000531162200003
dc.identifier.doi10.25135/rnp.170.19.11.1477
dc.type.versionpublishedVersion
dc.identifier.scopus2-s2.0-85084426886
dc.identifier.fulltexthttp://vinar.vin.bg.ac.rs/bitstream/id/22580/20200507090359A3-170-RNP-1911-1477.pdf


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