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Alignment-free method for functional annotation of amino acid substitutions: Application on epigenetic factors involved in hematologic malignancies
(PLOS One, 2021)
For the last couple of decades, there has been a significant growth in sequencing data, leading to an extraordinary increase in the number of gene variants. This places a challenge on the bioinformatics research community ...
Activity to Breast Cancer Cell Lines of Different Malignancy and Predicted Interaction with Protein Kinase C Isoforms of Royleanones
(International Journal of Molecular Sciences, 2020)
Plants have been used for centuries to treat several illnesses. The Plectranthus genus has a vast variety of species that has allowed the isolation of cytotoxic compounds with notable activities. The abietane diterpenes ...
Critical assessment of protein intrinsic disorder prediction
(Nature Methods, 2021)
Intrinsically disordered proteins, defying the traditional protein structure–function paradigm, are a challenge to study experimentally. Because a large part of our knowledge rests on computational predictions, it is crucial ...
Arginase Flavonoid Anti-Leishmanial in Silico Inhibitors Flagged against Anti-Targets
(Molecules, 2016)
Arginase, a drug target for the treatment of leishmaniasis, is involved in the biosynthesis of polyamines. Flavonoids are interesting natural compounds found in many foods and some of them may inhibit this enzyme. The ...
Tally-2.0: upgraded validator of tandem repeat detection in protein sequences
(Bioinformatics, 2020)
Motivation: Proteins containing tandem repeats (TRs) are abundant, frequently fold in elongated non-globular structures and perform vital functions. A number of computational tools have been developed to detect TRs in ...
Direct-acting antiviral drugs for treatment of hepatitis C virus infection-clinical trials data and chemistry of NS3/4A protease inhibitors
(Frontiers in Clinical Drug Research - Anti Infectives, 2020)
The hepatitis C virus (HCV) infection is a major and rising global health problem, affecting more than 71 million people worldwide. HCV is connected with several hepatic and extrahepatic disorders, containing several ...
DisProt in 2022: improved quality and accessibility of protein intrinsic disorder annotation
(Nucleic acids research, 2022)
The Database of Intrinsically Disordered Proteins (DisProt, URL: https://disprot.org) is the major repository of manually curated annotations of intrinsically disordered proteins and regions from the literature. We report ...
In vitro anti-influenza activity of in silico repurposed candidate drug Cycrimine
(Antiviral Therapy, 2020)
Background: Due to the limitations of current antiviral therapies because of drug resistance and the emergence of new circulating viral strains, novel effective antivirals are urgently needed. Results of the previous drug ...
Repurposing of antiparasitic drugs for Candidate SARS-CoV-2 Main Protease Inhibitors by combined in silico Method
(Department of Biology and Ecology : Faculty of Sciences University of Novi Sad, 2021)
The SARS-CoV-2 outbreak that is spreading rapidly around the world requires urgently effective treatments. Therefore, in silico drug repurposing represents a powerful strategy to enable the acceleration of the identification ...
Prediction of GO terms for IDPs based on highly connected components in PPI networks
(Department of Biology and Ecology : Faculty of Sciences University of Novi Sad, 2021)
Partitioning large biological networks can help biologists to retrieve new information for particular biological structures. In literature, various methods for partitioning and clustering biological networks have been ...