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Glucocorticoid receptor alpha translational isoforms as mediators of early adversities and negative emotional states
(Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2019)
Childhood trauma (CT) increases the risk for psychopathology through disturbed acquisition and extinction of fear. The effects of CT are mediated by abnormalities of the hypothalamic-pituitary-adrenal axis and glucocorticoid ...
Male-specific effects of lipopolysaccharide on glucocorticoid receptor nuclear translocation in the prefrontal cortex of depressive rats
(Psychopharmacology, 2016)
Inflammation plays a key role in the pathogenesis of major depressive disorder (MDD) for a subset of depressed individuals. One of the possible routes by which cytokines can induce depressive symptoms is by promoting the ...
Convergence of glycogen synthase kinase 3 beta and GR signaling in response to fluoxetine treatment in chronically stressed female and male rats
(Behavioural Brain Research, 2017)
Accumulating evidence strongly suggest that impaired glucocorticoid receptor (GR) signaling is involved in stress-related mood disorders, and nominate GR as a potential target for antidepressants (ADs). It is known that ...
The role of glucocorticoid receptor phosphorylation in the model of negative affective states
(World Journal of Biological Psychiatry, 2015)
Objectives. To develop a structural equation model of negative affectivity (NA) that involves interaction of glucocorticoid receptor (GR) signaling, personality dimensions and recent stressful life events. Methods. Seventy ...
Cholecalciferol ameliorates insulin signalling and insulin regulation of enzymes involved in glucose metabolism in the rat heart
(Archives of Physiology and Biochemistry, 2021)
Context The evidence on potential cross-talk of vitamin D and insulin in the regulation of cardiac metabolism is very scanty.Objective Cholecalciferol was administered to male Wistar rats for six weeks to study its effects ...
Social isolation stress-resilient rats reveal energy shift from glycolysis to oxidative phosphorylation in hippocampal nonsynaptic mitochondria
(Life Sciences, 2020)
Aims: To examine the differences in the hippocampal proteome profiles of resilience or susceptibility to chronic social isolation (CSIS), animal model of depression, and to identify biomarkers that can distinguish the two. ...
Antioxidant enzyme activity in rat hippocampus after chronic and acute stress exposure
(Annals of the New York Academy of Sciences, 2005)
Chronic exposure to stress alters the prooxidant-antioxidant balance, which might lead to the development of various human pathological states. In order to explain the role of antioxidant response in stress-induced injury, ...
The fatty acid amide hydrolase inhibitor URB597 modulates splenic catecholamines in chronically stressed female and male rats
(International Immunopharmacology, 2020)
The changes in sympathetic innervations in lymphoid organs could be a key factor in immune dysregulation. The endocannabinoid system has been shown to exhibit potent immunomodulatory effects that may differ between males ...
Response of a human melanoma cell line to low and high ionizing radiation
(Annals of the New York Academy of Sciences, 2007)
Effects of single irradiation with gamma rays and protons on human HTB140 melanoma cell growth were compared. Exponentially growing cells were irradiated close to the Bragg peak maximum of the unmodulated 62 MeV protons, ...
Modulation of Hippocampal Antioxidant Defense System in Chronically Stressed Rats by Lithium
(Oxidative Medicine and Cellular Longevity, 2019)
This study examined the effects of lithium on gene expression and activity of the antioxidant enzymes copper zinc superoxide dismutase (SOD1), manganese superoxide dismutase (SOD2), catalase (CAT), glutathione peroxidase ...