Brain capillary perfusion in the spontaneously hypertensive rat during the wake-sleep cycle
Само за регистроване кориснике
2004
Аутори
Silvani, AlessandroBojić, Tijana
Cianci, Tullia
Franzini, Carlo
Lenzi, Pierluigi
Lucchi, Maria Luisa
Zoccoli, Giovanna
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Hypertension is accompanied by circulatory changes in the brain and in other vascular districts; at disease onset, these changes may be largely functional and dependent on metabolic and vegetative drives. The wake-sleep cycle is a major physiological source of ultradian variability in autonomic function and in cerebral blood flow and metabolism. Aim of the study was to investigate whether sleep induces functional changes in the brain microcirculation in the developing hypertensive state. The fraction of brain capillaries perfused by plasma (perfused/ anatomical capillaries) was assessed in young (8-10 weeks) spontaneously hypertensive rats (SHR) during quiet wakefulness, quiet sleep and active sleep. The density of anatomical capillaries was assessed in two groups of animals using both a histochemical method (alkaline phosphatase, AP, for morphometric measurements) and an immunofluorescence method (anti-fibronectin antibodies, FN, to detect all existing capillaries). The density of per...fused capillaries was determined by intravascular injection of a fluorescent marker. The fraction of anatomical capillaries perfused by plasma was always close to maximal (0.96-0.97), without significant variations among the states of the wake-sleep cycle, and was the same for AP-stained and FN-stained sections. Data thus indicate that in this model of essential hypertension no functional changes in plasma perfusion of cerebral capillaries occur in the early stages of the disease.
Кључне речи:
hypertension / inbred SHR rats / cerebrovascular circulation / sleep / brain capillariesИзвор:
Experimental Brain Research, 2004, 154, 1, 44-49
DOI: 10.1007/s00221-003-1636-9
ISSN: 0014-4819
PubMed: 14661067
WoS: 000187127600006
Scopus: 2-s2.0-1642497440
Колекције
Институција/група
VinčaTY - JOUR AU - Silvani, Alessandro AU - Bojić, Tijana AU - Cianci, Tullia AU - Franzini, Carlo AU - Lenzi, Pierluigi AU - Lucchi, Maria Luisa AU - Zoccoli, Giovanna PY - 2004 UR - https://vinar.vin.bg.ac.rs/handle/123456789/8875 AB - Hypertension is accompanied by circulatory changes in the brain and in other vascular districts; at disease onset, these changes may be largely functional and dependent on metabolic and vegetative drives. The wake-sleep cycle is a major physiological source of ultradian variability in autonomic function and in cerebral blood flow and metabolism. Aim of the study was to investigate whether sleep induces functional changes in the brain microcirculation in the developing hypertensive state. The fraction of brain capillaries perfused by plasma (perfused/ anatomical capillaries) was assessed in young (8-10 weeks) spontaneously hypertensive rats (SHR) during quiet wakefulness, quiet sleep and active sleep. The density of anatomical capillaries was assessed in two groups of animals using both a histochemical method (alkaline phosphatase, AP, for morphometric measurements) and an immunofluorescence method (anti-fibronectin antibodies, FN, to detect all existing capillaries). The density of perfused capillaries was determined by intravascular injection of a fluorescent marker. The fraction of anatomical capillaries perfused by plasma was always close to maximal (0.96-0.97), without significant variations among the states of the wake-sleep cycle, and was the same for AP-stained and FN-stained sections. Data thus indicate that in this model of essential hypertension no functional changes in plasma perfusion of cerebral capillaries occur in the early stages of the disease. T2 - Experimental Brain Research T1 - Brain capillary perfusion in the spontaneously hypertensive rat during the wake-sleep cycle VL - 154 IS - 1 SP - 44 EP - 49 DO - 10.1007/s00221-003-1636-9 ER -
@article{ author = "Silvani, Alessandro and Bojić, Tijana and Cianci, Tullia and Franzini, Carlo and Lenzi, Pierluigi and Lucchi, Maria Luisa and Zoccoli, Giovanna", year = "2004", abstract = "Hypertension is accompanied by circulatory changes in the brain and in other vascular districts; at disease onset, these changes may be largely functional and dependent on metabolic and vegetative drives. The wake-sleep cycle is a major physiological source of ultradian variability in autonomic function and in cerebral blood flow and metabolism. Aim of the study was to investigate whether sleep induces functional changes in the brain microcirculation in the developing hypertensive state. The fraction of brain capillaries perfused by plasma (perfused/ anatomical capillaries) was assessed in young (8-10 weeks) spontaneously hypertensive rats (SHR) during quiet wakefulness, quiet sleep and active sleep. The density of anatomical capillaries was assessed in two groups of animals using both a histochemical method (alkaline phosphatase, AP, for morphometric measurements) and an immunofluorescence method (anti-fibronectin antibodies, FN, to detect all existing capillaries). The density of perfused capillaries was determined by intravascular injection of a fluorescent marker. The fraction of anatomical capillaries perfused by plasma was always close to maximal (0.96-0.97), without significant variations among the states of the wake-sleep cycle, and was the same for AP-stained and FN-stained sections. Data thus indicate that in this model of essential hypertension no functional changes in plasma perfusion of cerebral capillaries occur in the early stages of the disease.", journal = "Experimental Brain Research", title = "Brain capillary perfusion in the spontaneously hypertensive rat during the wake-sleep cycle", volume = "154", number = "1", pages = "44-49", doi = "10.1007/s00221-003-1636-9" }
Silvani, A., Bojić, T., Cianci, T., Franzini, C., Lenzi, P., Lucchi, M. L.,& Zoccoli, G.. (2004). Brain capillary perfusion in the spontaneously hypertensive rat during the wake-sleep cycle. in Experimental Brain Research, 154(1), 44-49. https://doi.org/10.1007/s00221-003-1636-9
Silvani A, Bojić T, Cianci T, Franzini C, Lenzi P, Lucchi ML, Zoccoli G. Brain capillary perfusion in the spontaneously hypertensive rat during the wake-sleep cycle. in Experimental Brain Research. 2004;154(1):44-49. doi:10.1007/s00221-003-1636-9 .
Silvani, Alessandro, Bojić, Tijana, Cianci, Tullia, Franzini, Carlo, Lenzi, Pierluigi, Lucchi, Maria Luisa, Zoccoli, Giovanna, "Brain capillary perfusion in the spontaneously hypertensive rat during the wake-sleep cycle" in Experimental Brain Research, 154, no. 1 (2004):44-49, https://doi.org/10.1007/s00221-003-1636-9 . .