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dc.creatorSamiec, Petr
dc.creatorŠvorc, Lubomir
dc.creatorStanković, Dalibor M.
dc.creatorVojs, Marian
dc.creatorMarton, Marian
dc.creatorNavratilova, Zuzana
dc.date.accessioned2020-11-13T08:17:05Z
dc.date.available2019-02-09
dc.date.issued2017
dc.identifier.issn0925-4005
dc.identifier.urihttps://vinar.vin.bg.ac.rs/handle/123456789/8853
dc.description.abstractThe boron-doped diamond electrodes (BDDEs) with different dopant levels were applied as advanced, mercury-free and modification-free electroanalytical platforms for simple and reliable quantification of benzodiazepines, bromazepam (BZ) and alprazolam (ALZ). Cyclic voltammetric measurements revealed that the electrode reactions of both analytes were manifested by one irreversible and diffusion-controlled reduction peak at -1.10V in Britton-Robinson buffer of pH 11 for BZ using lab-made BDDE with 1000 ppm B/C ratio and -0.84V in BR buffer of pH 5 for ALZ using commercial BDDE with 1000 ppm B/C ratio. Differential pulse voltammetry was used for construction of calibration curves for BZ and ALZ, respectively, with the analytical parameters as follows: the linear dynamic ranges of 1 x 10(-6)-1 x 10(-4) and 8 x 10(-7)-1 x 10(-4) mol/L, the detection limit of 3.1 x 10(-7) and 6.4 x 10(-7) mol/L and the excellent repeatability with the relative standard deviation below 3% for both drugs. The developed methods were applied to analysis of the pharmaceutical tablets with the recoveries from 97.33 to 100.85% for BZ and from 94.14 to 101.32% for ALZ. The usage of BDDEs as advanced electrochemical sensors in drug analysis represents a facile and effective analytical approach which may replace mercury-based sensors and chemically modified electrodes in previous benzodiazepines sensing. (C) 2017 Elsevier B.V. All rights reserved.en
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172030/RS//
dc.relationStudent grant competition (University of Ostrava) [SGS07/PrF/2015]
dc.relationStudent grant competition (University of Ostrava) [SGS03/PrF/2016]
dc.relationGrant Agency of the Slovak Republic [1/0489/16]
dc.relationSlovak Research and Development Agency [APVV-0365-12]
dc.relationinfo:eu-repo/grantAgreement/EC/FP7/621375/EU//
dc.relationSTU Grant scheme
dc.rightsembargoedAccessen
dc.sourceSensors and Actuators B: Chemicalen
dc.subjectBenzodiazepinesen
dc.subjectBoron-doped diamond electrodeen
dc.subjectElectrochemical sensoren
dc.subjectDifferential pulse voltammetryen
dc.subjectPharmaceutical tableten
dc.titleMercury-free and modification-free electroanalytical approach towards bromazepam and alprazolam sensing: A facile and efficient assay for their quantification in pharmaceuticals using boron-doped diamond electrodesen
dc.typearticleen
dc.rights.licenseBY-NC-ND
dcterms.abstractСтанковић, Далибор М.; Навратилова, Зузана; Шворц, Лубомир; Самиец, Петр; Војс, Мариан; Мартон, Мариан;
dc.citation.volume245
dc.citation.spage963
dc.citation.epage971
dc.identifier.wos000398760700113
dc.identifier.doi10.1016/j.snb.2017.02.023
dc.citation.rankaM21
dc.description.otherThis is accepted peer-reviewed version of the article: Samiec, P., Švorc, Ľ., Stanković, D. M., Vojs, M., Marton, M., & Navrátilová, Z. (2017). Mercury-free and modification-free electroanalytical approach towards bromazepam and alprazolam sensing: A facile and efficient assay for their quantification in pharmaceuticals using boron-doped diamond electrodes. Sensors and Actuators B: Chemical, 245, 963-971. [https://dx.doi.org/10.1016/j.snb.2017.02.023]
dc.description.otherPublished version: [https://vinar.vin.bg.ac.rs/handle/123456789/1504]
dc.type.versionacceptedVersion
dc.identifier.scopus2-s2.0-85013001578
dc.identifier.fulltexthttp://vinar.vin.bg.ac.rs/bitstream/id/22208/Samiec_MercuryFree_2017__AAM.pdf


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