Boron-doped diamond electrode as efficient sensing platform for simultaneous quantification of mefenamic acid and indomethacin
Authorized Users Only
2020
Authors
Petković, Branka B.
Ognjanović, Miloš

Krstić, Milena P.
Stanković, Vesna

Babincev, Ljiljana
Pergal, Marija V.
Stanković, Dalibor M.

Article (Published version)

© 2020 Elsevier B.V.
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Mefenamic acid and indomethacin, medicaments belonging to the group of non-steroidal anti-inflammatory agents, were determined separately and simultaneously at anodically prepared BDDE. Differential pulse voltammetry was used to establish simple and fast analytical procedure based on electrooxidation of mefenamic acid at 0.6 V and indomethacin at 1.0 V (and 1.1 V). At optimal conditions, it was suitable for highly sensitive and selective determination of these compounds with LODs comparable to previously reported modified electrodes. Additionally, considering the importance of these compounds, we proposed precise and accurate quantification of these species based on green and simple pre-treatable electrochemical sensor. The effect of interfering agents (tablet ingredients and vitamins) was appeared to be negligibly confirming a favourable selectivity of the method. The proposed method was analytically applied by simultaneously determining mefenamic acid and indomethacin in pharmaceutic...al formulations. © 2020 Elsevier B.V.
Keywords:
Mefenamic acid / Indomethacin / Anti-inflammatory drug analysis / Unmodified BDDESource:
Diamond and Related Materials, 2020, 105, 107785-Projects:
- Multiscale structuring of polymer nanocomposites and functional materials based on different precursors (RS-45022)
- Application of advanced oxidation processes and nanostructured oxide materials for the removal of pollutants from the environment, development and optimisation of instrumental techniques for efficiency monitoring (RS-172030)
- Magnetic and radionuclide labeled nanostructured materials for medical applications (RS-45015)
- EUREKA project E! 13303 MED-BIO-TEST
DOI: 10.1016/j.diamond.2020.107785
ISSN: 0925-9635