Optimization of the radiolabelling method for improved in vitro and in vivo stability of 90Y-albumin microspheres

Vukadinović, Aleksandar; Janković, Drina; Radović, Magdalena; Milanović, Zorana; Mirković, Marija D.; Stanković, Dragana; Vranješ-Đurić, Sanja

doi:10.1016/j.apradiso.2019.108984

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Vukadinović, Aleksandar

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Abstract

Biologically stable 90Y-labelled albumin microspheres (AMS) were developed by optimizing the process of their preparation. Three formulations of 90Y-AMS were initially prepared with high radiolabelling yield but depending on the step when the radionuclide 90Y and DTPA chelator were added, radiolabelled microspheres with different in vitro and in vivo stability were obtained. DTPA was proved as a useful chelating agent that tightly links radionuclide 90Y to albumin. Also, AMS radiolabelled via DTPA during preparation and before microspheres stabilization, showed significant in vitro and in vivo stability ready for the potential use in selective internal radiation therapy. © 2019 Elsevier Ltd

Keywords:

Human albumin microspheres / Y-90 / Radiolabelling / DTPA / In vivo stability

Source:
Applied Radiation and Isotopes, 2020, 156, 108984-

Funding / projects:

Magnetic and radionuclide labeled nanostructured materials for medical applications (RS-45015)

DOI: 10.1016/j.apradiso.2019.108984

ISSN: 0969-8043

PubMed: 31760344

WoS: 000514754100042

Scopus: 2-s2.0-85075208268

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	4
	1

TY  - JOUR
AU  - Vukadinović, Aleksandar
AU  - Janković, Drina
AU  - Radović, Magdalena
AU  - Milanović, Zorana
AU  - Mirković, Marija D.
AU  - Stanković, Dragana
AU  - Vranješ-Đurić, Sanja
PY  - 2020
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/8652
AB  - Biologically stable 90Y-labelled albumin microspheres (AMS) were developed by optimizing the process of their preparation. Three formulations of 90Y-AMS were initially prepared with high radiolabelling yield but depending on the step when the radionuclide 90Y and DTPA chelator were added, radiolabelled microspheres with different in vitro and in vivo stability were obtained. DTPA was proved as a useful chelating agent that tightly links radionuclide 90Y to albumin. Also, AMS radiolabelled via DTPA during preparation and before microspheres stabilization, showed significant in vitro and in vivo stability ready for the potential use in selective internal radiation therapy. © 2019 Elsevier Ltd
T2  - Applied Radiation and Isotopes
T1  - Optimization of the radiolabelling method for improved in vitro and in vivo stability of 90Y-albumin microspheres
VL  - 156
SP  - 108984
DO  - 10.1016/j.apradiso.2019.108984
ER  -

@article{
author = "Vukadinović, Aleksandar and Janković, Drina and Radović, Magdalena and Milanović, Zorana and Mirković, Marija D. and Stanković, Dragana and Vranješ-Đurić, Sanja",
year = "2020",
abstract = "Biologically stable 90Y-labelled albumin microspheres (AMS) were developed by optimizing the process of their preparation. Three formulations of 90Y-AMS were initially prepared with high radiolabelling yield but depending on the step when the radionuclide 90Y and DTPA chelator were added, radiolabelled microspheres with different in vitro and in vivo stability were obtained. DTPA was proved as a useful chelating agent that tightly links radionuclide 90Y to albumin. Also, AMS radiolabelled via DTPA during preparation and before microspheres stabilization, showed significant in vitro and in vivo stability ready for the potential use in selective internal radiation therapy. © 2019 Elsevier Ltd",
journal = "Applied Radiation and Isotopes",
title = "Optimization of the radiolabelling method for improved in vitro and in vivo stability of 90Y-albumin microspheres",
volume = "156",
pages = "108984",
doi = "10.1016/j.apradiso.2019.108984"
}

Vukadinović, A., Janković, D., Radović, M., Milanović, Z., Mirković, M. D., Stanković, D.,& Vranješ-Đurić, S.. (2020). Optimization of the radiolabelling method for improved in vitro and in vivo stability of 90Y-albumin microspheres. in Applied Radiation and Isotopes, 156, 108984.
https://doi.org/10.1016/j.apradiso.2019.108984

Vukadinović A, Janković D, Radović M, Milanović Z, Mirković MD, Stanković D, Vranješ-Đurić S. Optimization of the radiolabelling method for improved in vitro and in vivo stability of 90Y-albumin microspheres. in Applied Radiation and Isotopes. 2020;156:108984.
doi:10.1016/j.apradiso.2019.108984 .

Vukadinović, Aleksandar, Janković, Drina, Radović, Magdalena, Milanović, Zorana, Mirković, Marija D., Stanković, Dragana, Vranješ-Đurić, Sanja, "Optimization of the radiolabelling method for improved in vitro and in vivo stability of 90Y-albumin microspheres" in Applied Radiation and Isotopes, 156 (2020):108984,
https://doi.org/10.1016/j.apradiso.2019.108984 . .