Gd2O3 nanoparticles stabilized by hydrothermally modified dextrose for positive contrast magnetic resonance imaging
Само за регистроване кориснике
2016
Аутори
Babić-Stojić, Branka S.Jokanović, Vukoman R.
Milivojević, Dušan
Pozek, Miroslav
Jagličić, Zvonko
Makovec, Darko
Arsikin, Katarina M.
Paunović, Verica G.
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Gd2O3 nanoparticles of a few nm in size and their agglomerates dispersed in dextrose derived polymer template were synthesized by hydrothermal treatment. The produced nanosized material was investigated by TEM, FTIR spectroscopy, SQUID measurements and NMR relaxometry. Biological evaluation of this material was done by crystal violet and MTT assays to determine the cell viability. Longitudinal and transverse NMR relaxivities of water diluted Gd2O3 nanoparticle dispersions measured at the magnetic field of 1.5 T, estimated to be r(1)(Gd2O3)=9.6 s(-1) mM(-1) in the Gd concentration range 0.1-30 mM and r(2)(Gd2O3)=17.7 s(-1) mM(-1) in the lower concentration range 0.1-0.8 mM, are significantly higher than the corresponding relaxivities measured for the standard contrast agent r1 (Gd-DTPA)=4.1 s(-1) mM(-1) and r(2)(Gd-DTPA)= 5.1 s(-1) mM(-1). The ratio of the two relaxivities for Gd2O3 nanoparticles r(2)/r(1) = 1.8 is suitable for T-1-weighted imaging. Good MRI signal intensities of the wa...ter diluted Gd2O3 nanoparticle dispersions were recorded at lower Gd concentrations 0.2-0.8 mM. The Gd2O3 samples did not exert any significant cytotoxic effects at Gd concentrations of 0.2 mM and below. These properties of the produced Gd2O3 nanoparticles in hydrothermally modified dextrose make them promising for potential application in MRI for the design of a positive MRI contrast agent. (C) 2015 Elsevier B.V. All rights reserved.
Кључне речи:
Gadolinium oxide / Magnetic nanoparticles / Relaxivity / Magnetic resonance imaging / Contrast agents / ToxicityИзвор:
Journal of Magnetism and Magnetic Materials, 2016, 403, 118-126Финансирање / пројекти:
- Хемијско и структурно дизајнирање наноматеријала за примену у медицини и инжењерству ткива (RS-MESTD-Basic Research (BR or ON)-172026)
- Модулација сигналних путева који контролишу интрацелуларни енергетски баланс у терапији тумора и неуро-имуно-ендокриних поремећаја (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-41025)
DOI: 10.1016/j.jmmm.2015.11.075
ISSN: 0304-8853; 1873-4766
WoS: 000366588000018
Scopus: 2-s2.0-84949035605
Институција/група
VinčaTY - JOUR AU - Babić-Stojić, Branka S. AU - Jokanović, Vukoman R. AU - Milivojević, Dušan AU - Pozek, Miroslav AU - Jagličić, Zvonko AU - Makovec, Darko AU - Arsikin, Katarina M. AU - Paunović, Verica G. PY - 2016 UR - https://vinar.vin.bg.ac.rs/handle/123456789/857 AB - Gd2O3 nanoparticles of a few nm in size and their agglomerates dispersed in dextrose derived polymer template were synthesized by hydrothermal treatment. The produced nanosized material was investigated by TEM, FTIR spectroscopy, SQUID measurements and NMR relaxometry. Biological evaluation of this material was done by crystal violet and MTT assays to determine the cell viability. Longitudinal and transverse NMR relaxivities of water diluted Gd2O3 nanoparticle dispersions measured at the magnetic field of 1.5 T, estimated to be r(1)(Gd2O3)=9.6 s(-1) mM(-1) in the Gd concentration range 0.1-30 mM and r(2)(Gd2O3)=17.7 s(-1) mM(-1) in the lower concentration range 0.1-0.8 mM, are significantly higher than the corresponding relaxivities measured for the standard contrast agent r1 (Gd-DTPA)=4.1 s(-1) mM(-1) and r(2)(Gd-DTPA)= 5.1 s(-1) mM(-1). The ratio of the two relaxivities for Gd2O3 nanoparticles r(2)/r(1) = 1.8 is suitable for T-1-weighted imaging. Good MRI signal intensities of the water diluted Gd2O3 nanoparticle dispersions were recorded at lower Gd concentrations 0.2-0.8 mM. The Gd2O3 samples did not exert any significant cytotoxic effects at Gd concentrations of 0.2 mM and below. These properties of the produced Gd2O3 nanoparticles in hydrothermally modified dextrose make them promising for potential application in MRI for the design of a positive MRI contrast agent. (C) 2015 Elsevier B.V. All rights reserved. T2 - Journal of Magnetism and Magnetic Materials T1 - Gd2O3 nanoparticles stabilized by hydrothermally modified dextrose for positive contrast magnetic resonance imaging VL - 403 SP - 118 EP - 126 DO - 10.1016/j.jmmm.2015.11.075 ER -
@article{ author = "Babić-Stojić, Branka S. and Jokanović, Vukoman R. and Milivojević, Dušan and Pozek, Miroslav and Jagličić, Zvonko and Makovec, Darko and Arsikin, Katarina M. and Paunović, Verica G.", year = "2016", abstract = "Gd2O3 nanoparticles of a few nm in size and their agglomerates dispersed in dextrose derived polymer template were synthesized by hydrothermal treatment. The produced nanosized material was investigated by TEM, FTIR spectroscopy, SQUID measurements and NMR relaxometry. Biological evaluation of this material was done by crystal violet and MTT assays to determine the cell viability. Longitudinal and transverse NMR relaxivities of water diluted Gd2O3 nanoparticle dispersions measured at the magnetic field of 1.5 T, estimated to be r(1)(Gd2O3)=9.6 s(-1) mM(-1) in the Gd concentration range 0.1-30 mM and r(2)(Gd2O3)=17.7 s(-1) mM(-1) in the lower concentration range 0.1-0.8 mM, are significantly higher than the corresponding relaxivities measured for the standard contrast agent r1 (Gd-DTPA)=4.1 s(-1) mM(-1) and r(2)(Gd-DTPA)= 5.1 s(-1) mM(-1). The ratio of the two relaxivities for Gd2O3 nanoparticles r(2)/r(1) = 1.8 is suitable for T-1-weighted imaging. Good MRI signal intensities of the water diluted Gd2O3 nanoparticle dispersions were recorded at lower Gd concentrations 0.2-0.8 mM. The Gd2O3 samples did not exert any significant cytotoxic effects at Gd concentrations of 0.2 mM and below. These properties of the produced Gd2O3 nanoparticles in hydrothermally modified dextrose make them promising for potential application in MRI for the design of a positive MRI contrast agent. (C) 2015 Elsevier B.V. All rights reserved.", journal = "Journal of Magnetism and Magnetic Materials", title = "Gd2O3 nanoparticles stabilized by hydrothermally modified dextrose for positive contrast magnetic resonance imaging", volume = "403", pages = "118-126", doi = "10.1016/j.jmmm.2015.11.075" }
Babić-Stojić, B. S., Jokanović, V. R., Milivojević, D., Pozek, M., Jagličić, Z., Makovec, D., Arsikin, K. M.,& Paunović, V. G.. (2016). Gd2O3 nanoparticles stabilized by hydrothermally modified dextrose for positive contrast magnetic resonance imaging. in Journal of Magnetism and Magnetic Materials, 403, 118-126. https://doi.org/10.1016/j.jmmm.2015.11.075
Babić-Stojić BS, Jokanović VR, Milivojević D, Pozek M, Jagličić Z, Makovec D, Arsikin KM, Paunović VG. Gd2O3 nanoparticles stabilized by hydrothermally modified dextrose for positive contrast magnetic resonance imaging. in Journal of Magnetism and Magnetic Materials. 2016;403:118-126. doi:10.1016/j.jmmm.2015.11.075 .
Babić-Stojić, Branka S., Jokanović, Vukoman R., Milivojević, Dušan, Pozek, Miroslav, Jagličić, Zvonko, Makovec, Darko, Arsikin, Katarina M., Paunović, Verica G., "Gd2O3 nanoparticles stabilized by hydrothermally modified dextrose for positive contrast magnetic resonance imaging" in Journal of Magnetism and Magnetic Materials, 403 (2016):118-126, https://doi.org/10.1016/j.jmmm.2015.11.075 . .