Chitosan-based hydrogel wound dressings with electrochemically incorporated silver nanoparticles – In vitro study

Nešović, Katarina; Janković, Ana; Radetić, Tamara; Vukašinović-Sekulić, Maja; Kojić, Vesna V.; Živković, Ljiljana; Perić-Grujić, Aleksandra A.; Rhee, Kyong Yop; Mišković-Stanković, Vesna

doi:10.1016/j.eurpolymj.2019.109257

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Authors

Nešović, Katarina
Janković, Ana

Radetić, Tamara
Vukašinović-Sekulić, Maja

Kojić, Vesna V.

Živković, Ljiljana

Perić-Grujić, Aleksandra A.
Rhee, Kyong Yop

Mišković-Stanković, Vesna

Article (Published version)

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Abstract

In this work, we provide a facile path for the preparation of wound dressing materials with improved characteristics based on biocompatible chitosan and poly(vinyl alcohol) hydrogels with embedded silver nanoparticles (AgNPs) as a potent antimicrobial agent. The hydrogels were prepared via freezing-thawing method, whereas AgNPs were synthesized via an in situ electrochemical route. The excellent physicochemical properties of the obtained nanocomposite hydrogels were validated using different spectroscopic and microscopic techniques. The formation of sub-10 nm AgNPs was confirmed by UV–visible spectroscopy, dynamic light scattering and transmission electron microscopy. Swelling and silver release profiles were validated using several diffusion models. The hydrogels were proven to be non-cytotoxic using MTT test and possessed powerful antibacterial activity against Staphylococcus aureus and Escherichia coli, as determined by test in suspension, which affirmed their feasibility for wound ...

Keywords:

Chitosan hydrogel / Silver nanoparticles / Antibacterial wound dressings / Release profiles / Swelling kinetics

Source:
European Polymer Journal, 2019, 121, 109257-

Funding / projects:

Synthesis, processing and applications of nanostructured multifunctional materials with defined properties (RS-45019)
National Research Foundation of the Ministry of Education, Republic of Korea (Basic Science Research Program) [2018R1A2B5A02023190]

DOI: 10.1016/j.eurpolymj.2019.109257

ISSN: 0014-3057

WoS: 000504504800008

Scopus: 2-s2.0-85072807623

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TY - JOUR
AU - Nešović, Katarina
AU - Janković, Ana
AU - Radetić, Tamara
AU - Vukašinović-Sekulić, Maja
AU - Kojić, Vesna V.
AU - Živković, Ljiljana
AU - Perić-Grujić, Aleksandra A.
AU - Rhee, Kyong Yop
AU - Mišković-Stanković, Vesna
PY - 2019
UR - https://vinar.vin.bg.ac.rs/handle/123456789/8531
AB - In this work, we provide a facile path for the preparation of wound dressing materials with improved characteristics based on biocompatible chitosan and poly(vinyl alcohol) hydrogels with embedded silver nanoparticles (AgNPs) as a potent antimicrobial agent. The hydrogels were prepared via freezing-thawing method, whereas AgNPs were synthesized via an in situ electrochemical route. The excellent physicochemical properties of the obtained nanocomposite hydrogels were validated using different spectroscopic and microscopic techniques. The formation of sub-10 nm AgNPs was confirmed by UV–visible spectroscopy, dynamic light scattering and transmission electron microscopy. Swelling and silver release profiles were validated using several diffusion models. The hydrogels were proven to be non-cytotoxic using MTT test and possessed powerful antibacterial activity against Staphylococcus aureus and Escherichia coli, as determined by test in suspension, which affirmed their feasibility for wound dressing applications. © 2019 Elsevier Ltd
T2 - European Polymer Journal
T1 - Chitosan-based hydrogel wound dressings with electrochemically incorporated silver nanoparticles – In vitro study
VL - 121
SP - 109257
DO - 10.1016/j.eurpolymj.2019.109257
ER -

@article{
author = "Nešović, Katarina and Janković, Ana and Radetić, Tamara and Vukašinović-Sekulić, Maja and Kojić, Vesna V. and Živković, Ljiljana and Perić-Grujić, Aleksandra A. and Rhee, Kyong Yop and Mišković-Stanković, Vesna",
year = "2019",
abstract = "In this work, we provide a facile path for the preparation of wound dressing materials with improved characteristics based on biocompatible chitosan and poly(vinyl alcohol) hydrogels with embedded silver nanoparticles (AgNPs) as a potent antimicrobial agent. The hydrogels were prepared via freezing-thawing method, whereas AgNPs were synthesized via an in situ electrochemical route. The excellent physicochemical properties of the obtained nanocomposite hydrogels were validated using different spectroscopic and microscopic techniques. The formation of sub-10 nm AgNPs was confirmed by UV–visible spectroscopy, dynamic light scattering and transmission electron microscopy. Swelling and silver release profiles were validated using several diffusion models. The hydrogels were proven to be non-cytotoxic using MTT test and possessed powerful antibacterial activity against Staphylococcus aureus and Escherichia coli, as determined by test in suspension, which affirmed their feasibility for wound dressing applications. © 2019 Elsevier Ltd",
journal = "European Polymer Journal",
title = "Chitosan-based hydrogel wound dressings with electrochemically incorporated silver nanoparticles – In vitro study",
volume = "121",
pages = "109257",
doi = "10.1016/j.eurpolymj.2019.109257"
}

Nešović, K., Janković, A., Radetić, T., Vukašinović-Sekulić, M., Kojić, V. V., Živković, L., Perić-Grujić, A. A., Rhee, K. Y.,& Mišković-Stanković, V.. (2019). Chitosan-based hydrogel wound dressings with electrochemically incorporated silver nanoparticles – In vitro study. in European Polymer Journal, 121, 109257.
https://doi.org/10.1016/j.eurpolymj.2019.109257

Nešović K, Janković A, Radetić T, Vukašinović-Sekulić M, Kojić VV, Živković L, Perić-Grujić AA, Rhee KY, Mišković-Stanković V. Chitosan-based hydrogel wound dressings with electrochemically incorporated silver nanoparticles – In vitro study. in European Polymer Journal. 2019;121:109257.
doi:10.1016/j.eurpolymj.2019.109257 .

Nešović, Katarina, Janković, Ana, Radetić, Tamara, Vukašinović-Sekulić, Maja, Kojić, Vesna V., Živković, Ljiljana, Perić-Grujić, Aleksandra A., Rhee, Kyong Yop, Mišković-Stanković, Vesna, "Chitosan-based hydrogel wound dressings with electrochemically incorporated silver nanoparticles – In vitro study" in European Polymer Journal, 121 (2019):109257,
https://doi.org/10.1016/j.eurpolymj.2019.109257 . .