Chitosan-based hydrogel wound dressings with electrochemically incorporated silver nanoparticles – In vitro study
Kojić, Vesna V.
Perić-Grujić, Aleksandra A.
Rhee, Kyong Yop
Article (Published version)
© 2019 Elsevier Ltd
MetadataShow full item record
In this work, we provide a facile path for the preparation of wound dressing materials with improved characteristics based on biocompatible chitosan and poly(vinyl alcohol) hydrogels with embedded silver nanoparticles (AgNPs) as a potent antimicrobial agent. The hydrogels were prepared via freezing-thawing method, whereas AgNPs were synthesized via an in situ electrochemical route. The excellent physicochemical properties of the obtained nanocomposite hydrogels were validated using different spectroscopic and microscopic techniques. The formation of sub-10 nm AgNPs was confirmed by UV–visible spectroscopy, dynamic light scattering and transmission electron microscopy. Swelling and silver release profiles were validated using several diffusion models. The hydrogels were proven to be non-cytotoxic using MTT test and possessed powerful antibacterial activity against Staphylococcus aureus and Escherichia coli, as determined by test in suspension, which affirmed their feasibility for wound ...dressing applications. © 2019 Elsevier Ltd
Keywords:Chitosan hydrogel / Silver nanoparticles / Antibacterial wound dressings / Release profiles / Swelling kinetics
Source:European Polymer Journal, 2019, 121, 109257-
- Synthesis, processing and applications of nanostructured multifunctional materials with defined properties (RS-45019)
- National Research Foundation of the Ministry of Education, Republic of Korea (Basic Science Research Program) [2018R1A2B5A02023190]