Tetravalent Metal Ion Guests in Polyoxopalladate Chemistry: Synthesis and Anticancer Activity of [MO 8 Pd 12 (PO 4 ) 8 ] 12– (M = Sn IV , Pb IV )

The first two examples of polyoxopalladates(II) (POPs) containing tetravalent metal ion guests, [MO8Pd12(PO4)8]12- (M = SnIV, PbIV), have been prepared and structurally characterized in the solid state, solution, and gas phase. The interactions of the metal ion guests and the palladium-oxo shell were studied by theoretical calculations. The POPs were shown to possess anticancer activity by causing oxidative stress inducing caspase activation and consecutive apoptosis of leukemic cells.

Source:
Inorganic Chemistry, 2019, 58, 17, 11294-11299

Projects:

German Research Foundation (DFG) [DFG-KO-2288/20-1]
German Research Foundation (DFG) [DEG-KO-2288/16-1]
Jacobs University
China Scholarship Council
Spanish Ministry of Science [CTQ2017-87269-P]
Generalitat de Catalunya [2017SGR629]
ICREA
CMST COST Action [CM1203]
Modulation of intracellular energy balance-controlling signalling pathways in therapy of cancer and neuro-immuno-endocrine disorders (RS-41025)
National Natural Science Foundation of China [21701010]
Hungarian National Research, Development and Innovation Office - NKFIH [NKFI NN 128368]

DOI: 10.1021/acs.inorgchem.9b01129

ISSN: 0020-1669

PubMed: 31411862

WoS: 000484066500006

Scopus: 2-s2.0-85071784200

[ Google Scholar ]


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	4

TY  - JOUR
AU  - Yang, Peng
AU  - Ma, Tian
AU  - Lang, Zhongling
AU  - Misirlić-Denčić, Sonja
AU  - Isaković, Anđelka
AU  - Benyei, Attila
AU  - Čolović, Mirjana B.
AU  - Marković, Ivanka
AU  - Krstić, Danijela Z.
AU  - Poblet, Josep M.
AU  - Lin, Zhengguo
AU  - Kortz, Ulrich
PY  - 2019
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/8499
AB  - The first two examples of polyoxopalladates(II) (POPs) containing tetravalent metal ion guests, [MO8Pd12(PO4)8]12- (M = SnIV, PbIV), have been prepared and structurally characterized in the solid state, solution, and gas phase. The interactions of the metal ion guests and the palladium-oxo shell were studied by theoretical calculations. The POPs were shown to possess anticancer activity by causing oxidative stress inducing caspase activation and consecutive apoptosis of leukemic cells.
T2  - Inorganic Chemistry
T1  - Tetravalent Metal Ion Guests in Polyoxopalladate Chemistry: Synthesis and Anticancer Activity of [MO 8 Pd 12 (PO 4 ) 8 ] 12– (M = Sn IV , Pb IV )
VL  - 58
IS  - 17
SP  - 11294
EP  - 11299
DO  - 10.1021/acs.inorgchem.9b01129
ER  -

@article{
author = "Yang, Peng and Ma, Tian and Lang, Zhongling and Misirlić-Denčić, Sonja and Isaković, Anđelka and Benyei, Attila and Čolović, Mirjana B. and Marković, Ivanka and Krstić, Danijela Z. and Poblet, Josep M. and Lin, Zhengguo and Kortz, Ulrich",
year = "2019",
url = "http://vinar.vin.bg.ac.rs/handle/123456789/8499",
abstract = "The first two examples of polyoxopalladates(II) (POPs) containing tetravalent metal ion guests, [MO8Pd12(PO4)8]12- (M = SnIV, PbIV), have been prepared and structurally characterized in the solid state, solution, and gas phase. The interactions of the metal ion guests and the palladium-oxo shell were studied by theoretical calculations. The POPs were shown to possess anticancer activity by causing oxidative stress inducing caspase activation and consecutive apoptosis of leukemic cells.",
journal = "Inorganic Chemistry",
title = "Tetravalent Metal Ion Guests in Polyoxopalladate Chemistry: Synthesis and Anticancer Activity of [MO 8 Pd 12 (PO 4 ) 8 ] 12– (M = Sn IV , Pb IV )",
volume = "58",
number = "17",
pages = "11294-11299",
doi = "10.1021/acs.inorgchem.9b01129"
}

Yang, P., Ma, T., Lang, Z., Misirlić-Denčić, S., Isaković, A., Benyei, A., Čolović, M. B., Marković, I., Krstić, D. Z., Poblet, J. M., Lin, Z.,& Kortz, U. (2019). Tetravalent Metal Ion Guests in Polyoxopalladate Chemistry: Synthesis and Anticancer Activity of [MO 8 Pd 12 (PO 4 ) 8 ] 12– (M = Sn IV , Pb IV ).
Inorganic Chemistry, 58(17), 11294-11299.
https://doi.org/10.1021/acs.inorgchem.9b01129

Yang P, Ma T, Lang Z, Misirlić-Denčić S, Isaković A, Benyei A, Čolović MB, Marković I, Krstić DZ, Poblet JM, Lin Z, Kortz U. Tetravalent Metal Ion Guests in Polyoxopalladate Chemistry: Synthesis and Anticancer Activity of [MO 8 Pd 12 (PO 4 ) 8 ] 12– (M = Sn IV , Pb IV ). Inorganic Chemistry. 2019;58(17):11294-11299

Yang Peng, Ma Tian, Lang Zhongling, Misirlić-Denčić Sonja, Isaković Anđelka, Benyei Attila, Čolović Mirjana B., Marković Ivanka, Krstić Danijela Z., Poblet Josep M., Lin Zhengguo, Kortz Ulrich, "Tetravalent Metal Ion Guests in Polyoxopalladate Chemistry: Synthesis and Anticancer Activity of [MO 8 Pd 12 (PO 4 ) 8 ] 12– (M = Sn IV , Pb IV )" Inorganic Chemistry, 58, no. 17 (2019):11294-11299,
https://doi.org/10.1021/acs.inorgchem.9b01129 .