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dc.creatorObradović, Milan M.
dc.creatorZafirović, Sonja
dc.creatorEssack, Magbubah
dc.creatorDimitrov, Jelena
dc.creatorŽivković, Lada
dc.creatorSpremo-Potparević, Biljana
dc.creatorRadak, Đorđe J.
dc.creatorBajić, Vladimir B.
dc.creatorIsenović, Esma R.
dc.date.accessioned2020-02-12T09:39:10Z
dc.date.available2020-02-12T09:39:10Z
dc.date.issued2020
dc.identifier.issn0306-9877
dc.identifier.urihttp://vinar.vin.bg.ac.rs/handle/123456789/8487
dc.description.abstractTo remedy carotid artery stenosis and prevent stroke surgical intervention is commonly used, and the gold standard being carotid endarterectomy (CEA). During CEA cerebrovascular hemoglobin oxygen saturation decreases and when this decrease reaches critical levels it leads to cerebral hypoxia that causes neuronal damage. One of the proposed mechanism that affects changes during CEA and contribute to acute brain ischemia (ABI) is oxidative stress. The increased production of reactive oxygen species and reactive nitrogen species during ABI may cause an unregulated inflammatory response and further lead to structural and functional injury of neurons. Antioxidant activity are involved in the protection against neuronal damage after cerebral ischemia. We hypothesized that neuronal injury and poor outcomes in patients undergoing CEA may be results of oxidative stress that disturbed function of antioxidant enzymes and contributed to the DNA damage in lymphocytes. © 2019 The Authors
dc.language.isoen
dc.publisherChurchill Livingstone
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173033/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41002/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173034/RS//
dc.relationCOST Action [CA15132, ‘hCOMET’]
dc.relationKAUST grant [OSR#4129]
dc.relationKAUST Base Research Fund [BAS/1/1606-01-01]
dc.relationKAUST Office of Sponsored Research (OSR) [FCC/1/1976-17-01]
dc.rightsopenAccess
dc.sourceMedical Hypotheses
dc.subjectSuperoxide dismutaseen
dc.subjectCatalaseen
dc.subjectDNA damageen
dc.subjectAcute brain ischemiaen
dc.subjectCerebrovascular hemoglobin oxygen saturationen
dc.titleAntioxidant enzymes expression in lymphocytes of patients undergoing carotid endarterectomyen
dc.typearticleen
dc.rights.licenseBY-NC-ND
dcterms.abstractЕссацк, М; Бајиц, В Б; Исеновић, Есма Р.; Димитров, Ј; Зивковиц, Л; Спремо-Потпаревиц, Б; Радак, Д; Обрадовиц, М; Зафировиц, С;
dc.rights.holder© 2019 The Authors
dc.citation.volume134
dc.citation.spage109419
dc.identifier.wos000510971500004
dc.identifier.doi10.1016/j.mehy.2019.109419
dc.citation.rankM23~
dc.identifier.pmid31622925
dc.type.versionpublishedVersion
dc.identifier.scopus2-s2.0-85073096930
dc.identifier.fulltexthttp://vinar.vin.bg.ac.rs/bitstream/id/21077/1-s2.0-S0306987719310497-main.pdf


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