Redox control of vascular biology
Autori
Obradović, Milan M.Essack, Magbubah
Zafirović, Sonja
Sudar-Milovanović, Emina
Bajić, Vladan P.
Van Neste, Christophe
Trpković, Andreja
Stanimirović, Julijana
Bajić, Vladimir B.
Isenović, Esma R.
Prikaz (Objavljena verzija)
,
© 2019 The Authors. BioFactors published by Wiley Periodicals, Inc. on behalf of International Union of Biochemistry and Molecular Biology
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Redox control is lost when the antioxidant defense system cannot remove abnormally high concentrations of signaling molecules, such as reactive oxygen species (ROS). Chronically elevated levels of ROS cause oxidative stress that may eventually lead to cancer and cardiovascular and neurodegenerative diseases. In this review, we focus on redox effects in the vascular system. We pay close attention to the subcompartments of the vascular system (endothelium, smooth muscle cell layer) and give an overview of how redox changes influence those different compartments. We also review the core aspects of redox biology, cardiovascular physiology, and pathophysiology. Moreover, the topic-specific knowledgebase DES-RedoxVasc was used to develop two case studies, one focused on endothelial cells and the other on the vascular smooth muscle cells, as a starting point to possibly extend our knowledge of redox control in vascular biology. © 2019 The Authors. BioFactors published by Wiley Periodicals, In...c. on behalf of International Union of Biochemistry and Molecular Biology.
Ključne reči:
cardiovascular diseases / cardiovascular system / reactive oxygen species / redoxIzvor:
BioFactors, 2020, 46, 2, 246-262Finansiranje / projekti:
- Hormonska regulacija ekspresije i aktivnosti azot oksid sintaze i natrijum-kalijumove pumpe u eksperimentalnim modelima insulinske rezistencije, dijabetesa i kardiovaskularnih poremećaja (RS-MESTD-Basic Research (BR or ON)-173033)
- KAUST [OSR#4129]
- KAUST Base Research Fund [BAS/1/1606‐01‐01]
- KAUST Office of Sponsored Research (OSR) [FCC/1/1976‐24‐01]
- KAUST Office of Sponsored Research (OSR) [FCC/1/1976‐17‐01]
- Aberacije ćelijskog ciklusa i uticaj oksidativnog stresa na neurodegenerativne procese i malignu transformaciju ćelije (RS-MESTD-Basic Research (BR or ON)-173034)
DOI: 10.1002/biof.1559
ISSN: 0951-6433
PubMed: 31483915
WoS: 000524885800007
Scopus: 2-s2.0-85071758400
Kolekcije
Institucija/grupa
VinčaTY - JOUR AU - Obradović, Milan M. AU - Essack, Magbubah AU - Zafirović, Sonja AU - Sudar-Milovanović, Emina AU - Bajić, Vladan P. AU - Van Neste, Christophe AU - Trpković, Andreja AU - Stanimirović, Julijana AU - Bajić, Vladimir B. AU - Isenović, Esma R. PY - 2020 UR - https://vinar.vin.bg.ac.rs/handle/123456789/8486 AB - Redox control is lost when the antioxidant defense system cannot remove abnormally high concentrations of signaling molecules, such as reactive oxygen species (ROS). Chronically elevated levels of ROS cause oxidative stress that may eventually lead to cancer and cardiovascular and neurodegenerative diseases. In this review, we focus on redox effects in the vascular system. We pay close attention to the subcompartments of the vascular system (endothelium, smooth muscle cell layer) and give an overview of how redox changes influence those different compartments. We also review the core aspects of redox biology, cardiovascular physiology, and pathophysiology. Moreover, the topic-specific knowledgebase DES-RedoxVasc was used to develop two case studies, one focused on endothelial cells and the other on the vascular smooth muscle cells, as a starting point to possibly extend our knowledge of redox control in vascular biology. © 2019 The Authors. BioFactors published by Wiley Periodicals, Inc. on behalf of International Union of Biochemistry and Molecular Biology. T2 - BioFactors T1 - Redox control of vascular biology VL - 46 IS - 2 SP - 246 EP - 262 DO - 10.1002/biof.1559 ER -
@article{ author = "Obradović, Milan M. and Essack, Magbubah and Zafirović, Sonja and Sudar-Milovanović, Emina and Bajić, Vladan P. and Van Neste, Christophe and Trpković, Andreja and Stanimirović, Julijana and Bajić, Vladimir B. and Isenović, Esma R.", year = "2020", abstract = "Redox control is lost when the antioxidant defense system cannot remove abnormally high concentrations of signaling molecules, such as reactive oxygen species (ROS). Chronically elevated levels of ROS cause oxidative stress that may eventually lead to cancer and cardiovascular and neurodegenerative diseases. In this review, we focus on redox effects in the vascular system. We pay close attention to the subcompartments of the vascular system (endothelium, smooth muscle cell layer) and give an overview of how redox changes influence those different compartments. We also review the core aspects of redox biology, cardiovascular physiology, and pathophysiology. Moreover, the topic-specific knowledgebase DES-RedoxVasc was used to develop two case studies, one focused on endothelial cells and the other on the vascular smooth muscle cells, as a starting point to possibly extend our knowledge of redox control in vascular biology. © 2019 The Authors. BioFactors published by Wiley Periodicals, Inc. on behalf of International Union of Biochemistry and Molecular Biology.", journal = "BioFactors", title = "Redox control of vascular biology", volume = "46", number = "2", pages = "246-262", doi = "10.1002/biof.1559" }
Obradović, M. M., Essack, M., Zafirović, S., Sudar-Milovanović, E., Bajić, V. P., Van Neste, C., Trpković, A., Stanimirović, J., Bajić, V. B.,& Isenović, E. R.. (2020). Redox control of vascular biology. in BioFactors, 46(2), 246-262. https://doi.org/10.1002/biof.1559
Obradović MM, Essack M, Zafirović S, Sudar-Milovanović E, Bajić VP, Van Neste C, Trpković A, Stanimirović J, Bajić VB, Isenović ER. Redox control of vascular biology. in BioFactors. 2020;46(2):246-262. doi:10.1002/biof.1559 .
Obradović, Milan M., Essack, Magbubah, Zafirović, Sonja, Sudar-Milovanović, Emina, Bajić, Vladan P., Van Neste, Christophe, Trpković, Andreja, Stanimirović, Julijana, Bajić, Vladimir B., Isenović, Esma R., "Redox control of vascular biology" in BioFactors, 46, no. 2 (2020):246-262, https://doi.org/10.1002/biof.1559 . .