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dc.creatorGluvić, Zoran
dc.creatorObradović, Milan M.
dc.creatorSudar-Milovanović, Emina
dc.creatorZafirović, Sonja
dc.creatorRadak, Đorđe J.
dc.creatorEssack, Magbubah
dc.creatorBajić, Vladimir B.
dc.creatorGojobori, Takashi
dc.creatorIsenović, Esma R.
dc.date.accessioned2020-02-05T13:10:59Z
dc.date.available2020-02-05T13:10:59Z
dc.date.issued2020
dc.identifier.issn0753-3322
dc.identifier.urihttp://vinar.vin.bg.ac.rs/handle/123456789/8474
dc.description.abstractHypothyroidism is a common endocrine disorder that predominantly occurs in females. It is associated with an increased risk of cardiovascular diseases (CVD), but the molecular mechanism is not known. Disturbance in lipid metabolism, the regulation of oxidative stress, and inflammation characterize the progression of subclinical hypothyroidism. The initiation and progression of endothelial dysfunction also exhibit these changes, which is the initial step in developing CVD. Animal and human studies highlight the critical role of nitric oxide (NO) as a reliable biomarker for cardiovascular risk in subclinical and clinical hypothyroidism. In this review, we summarize the recent literature findings associated with NO production by the thyroid hormones in both physiological and pathophysiological conditions. We also discuss the levothyroxine treatment effect on serum NO levels in hypothyroid patients. © 2020 The Authorsen
dc.language.isoen
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173033/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41002/RS//
dc.relationKAUST grant OSR#4 129
dc.relationKAUST Base Research Funds [BAS/1/1606-01-01]
dc.relationKAUST Base Research Funds [BAS/1/1059-01-01]
dc.relationKAUST Office of Sponsored Research (OSR) [FCC/1/1976-17-01]
dc.rightsopenAccess
dc.sourceBiomedicine & Pharmacotherapy
dc.subjectCardiovascular diseasesen
dc.subjectEndothelial dysfunctionen
dc.subjectHypothyroidismen
dc.subjectLevothyroxineen
dc.subjectNitric oxideen
dc.titleRegulation of nitric oxide production in hypothyroidismen
dc.typearticleen
dc.rights.licenseBY-NC-ND
dcterms.abstractЗафировић, Соња С; Исеновић, Есма Р.; Глувић, Зоран М; Обрадовић, Милан М; Судар-Миловановић, Емина М; Радак, Ђорђе Ј; Ессацк, Магбубах М; Бајић, Владимир Б; Такасхи, Гојобори;
dc.rights.holder© 2020 The Authors
dc.citation.volume124
dc.citation.spage109881
dc.identifier.wos000512532600035
dc.identifier.doi10.1016/j.biopha.2020.109881
dc.citation.rankM21~
dc.identifier.pmid31986413
dc.type.versionpublishedVersion
dc.identifier.scopus2-s2.0-85078142903
dc.identifier.fulltexthttp://vinar.vin.bg.ac.rs/bitstream/id/21050/1-s2.0-S0753332220300718-main.pdf


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