Regulation of nitric oxide production in hypothyroidism
Аутори
Gluvić, ZoranObradović, Milan M.
Sudar-Milovanović, Emina
Zafirović, Sonja
Radak, Đorđe J.
Essack, Magbubah
Bajić, Vladimir B.
Gojobori, Takashi
Isenović, Esma R.
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Hypothyroidism is a common endocrine disorder that predominantly occurs in females. It is associated with an increased risk of cardiovascular diseases (CVD), but the molecular mechanism is not known. Disturbance in lipid metabolism, the regulation of oxidative stress, and inflammation characterize the progression of subclinical hypothyroidism. The initiation and progression of endothelial dysfunction also exhibit these changes, which is the initial step in developing CVD. Animal and human studies highlight the critical role of nitric oxide (NO) as a reliable biomarker for cardiovascular risk in subclinical and clinical hypothyroidism. In this review, we summarize the recent literature findings associated with NO production by the thyroid hormones in both physiological and pathophysiological conditions. We also discuss the levothyroxine treatment effect on serum NO levels in hypothyroid patients. © 2020 The Authors
Кључне речи:
Cardiovascular diseases / Endothelial dysfunction / Hypothyroidism / Levothyroxine / Nitric oxideИзвор:
Biomedicine and Pharmacotherapy, 2020, 124, 109881-Финансирање / пројекти:
- Хормонска регулација експресије и активности азот оксид синтазе и натријум-калијумове пумпе у експерименталним моделима инсулинске резистенције, дијабетеса и кардиоваскуларних поремећаја (RS-MESTD-Basic Research (BR or ON)-173033)
- Каротидна болест у Србији - патолошка динамика, превенција, дијагностика и иновативни терапијски поступци (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-41002)
- KAUST grant OSR#4 129
- KAUST Base Research Funds [BAS/1/1606-01-01]
- KAUST Base Research Funds [BAS/1/1059-01-01]
- KAUST Office of Sponsored Research (OSR) [FCC/1/1976-17-01]
DOI: 10.1016/j.biopha.2020.109881
ISSN: 0753-3322
PubMed: 31986413
WoS: 000512532600035
Scopus: 2-s2.0-85078142903
Колекције
Институција/група
VinčaTY - JOUR AU - Gluvić, Zoran AU - Obradović, Milan M. AU - Sudar-Milovanović, Emina AU - Zafirović, Sonja AU - Radak, Đorđe J. AU - Essack, Magbubah AU - Bajić, Vladimir B. AU - Gojobori, Takashi AU - Isenović, Esma R. PY - 2020 UR - https://vinar.vin.bg.ac.rs/handle/123456789/8474 AB - Hypothyroidism is a common endocrine disorder that predominantly occurs in females. It is associated with an increased risk of cardiovascular diseases (CVD), but the molecular mechanism is not known. Disturbance in lipid metabolism, the regulation of oxidative stress, and inflammation characterize the progression of subclinical hypothyroidism. The initiation and progression of endothelial dysfunction also exhibit these changes, which is the initial step in developing CVD. Animal and human studies highlight the critical role of nitric oxide (NO) as a reliable biomarker for cardiovascular risk in subclinical and clinical hypothyroidism. In this review, we summarize the recent literature findings associated with NO production by the thyroid hormones in both physiological and pathophysiological conditions. We also discuss the levothyroxine treatment effect on serum NO levels in hypothyroid patients. © 2020 The Authors T2 - Biomedicine and Pharmacotherapy T1 - Regulation of nitric oxide production in hypothyroidism VL - 124 SP - 109881 DO - 10.1016/j.biopha.2020.109881 ER -
@article{ author = "Gluvić, Zoran and Obradović, Milan M. and Sudar-Milovanović, Emina and Zafirović, Sonja and Radak, Đorđe J. and Essack, Magbubah and Bajić, Vladimir B. and Gojobori, Takashi and Isenović, Esma R.", year = "2020", abstract = "Hypothyroidism is a common endocrine disorder that predominantly occurs in females. It is associated with an increased risk of cardiovascular diseases (CVD), but the molecular mechanism is not known. Disturbance in lipid metabolism, the regulation of oxidative stress, and inflammation characterize the progression of subclinical hypothyroidism. The initiation and progression of endothelial dysfunction also exhibit these changes, which is the initial step in developing CVD. Animal and human studies highlight the critical role of nitric oxide (NO) as a reliable biomarker for cardiovascular risk in subclinical and clinical hypothyroidism. In this review, we summarize the recent literature findings associated with NO production by the thyroid hormones in both physiological and pathophysiological conditions. We also discuss the levothyroxine treatment effect on serum NO levels in hypothyroid patients. © 2020 The Authors", journal = "Biomedicine and Pharmacotherapy", title = "Regulation of nitric oxide production in hypothyroidism", volume = "124", pages = "109881", doi = "10.1016/j.biopha.2020.109881" }
Gluvić, Z., Obradović, M. M., Sudar-Milovanović, E., Zafirović, S., Radak, Đ. J., Essack, M., Bajić, V. B., Gojobori, T.,& Isenović, E. R.. (2020). Regulation of nitric oxide production in hypothyroidism. in Biomedicine and Pharmacotherapy, 124, 109881. https://doi.org/10.1016/j.biopha.2020.109881
Gluvić Z, Obradović MM, Sudar-Milovanović E, Zafirović S, Radak ĐJ, Essack M, Bajić VB, Gojobori T, Isenović ER. Regulation of nitric oxide production in hypothyroidism. in Biomedicine and Pharmacotherapy. 2020;124:109881. doi:10.1016/j.biopha.2020.109881 .
Gluvić, Zoran, Obradović, Milan M., Sudar-Milovanović, Emina, Zafirović, Sonja, Radak, Đorđe J., Essack, Magbubah, Bajić, Vladimir B., Gojobori, Takashi, Isenović, Esma R., "Regulation of nitric oxide production in hypothyroidism" in Biomedicine and Pharmacotherapy, 124 (2020):109881, https://doi.org/10.1016/j.biopha.2020.109881 . .