Regulation of nitric oxide production in hypothyroidism
Obradović, Milan M.
Radak, Đorđe J.
Bajić, Vladimir B.
Isenović, Esma R.
Article (Published version)
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Hypothyroidism is a common endocrine disorder that predominantly occurs in females. It is associated with an increased risk of cardiovascular diseases (CVD), but the molecular mechanism is not known. Disturbance in lipid metabolism, the regulation of oxidative stress, and inflammation characterize the progression of subclinical hypothyroidism. The initiation and progression of endothelial dysfunction also exhibit these changes, which is the initial step in developing CVD. Animal and human studies highlight the critical role of nitric oxide (NO) as a reliable biomarker for cardiovascular risk in subclinical and clinical hypothyroidism. In this review, we summarize the recent literature findings associated with NO production by the thyroid hormones in both physiological and pathophysiological conditions. We also discuss the levothyroxine treatment effect on serum NO levels in hypothyroid patients. © 2020 The Authors
Keywords:Cardiovascular diseases / Endothelial dysfunction / Hypothyroidism / Levothyroxine / Nitric oxide
Source:Biomedicine & Pharmacotherapy, 2020, 124, 109881-
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- KAUST grant OSR#4 129
- KAUST Base Research Funds [BAS/1/1606-01-01]
- KAUST Base Research Funds [BAS/1/1059-01-01]
- KAUST Office of Sponsored Research (OSR) [FCC/1/1976-17-01]