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Antioksidativni status i kliničko-patološki parametri kod obolelih od Parkinsonove bolesti

dc.creatorMiletić Vukajlović, Jadranka
dc.creatorPejić, Snežana
dc.creatorTodorović, Ana
dc.creatorValenta-Šobot, Ana
dc.creatorDrakulić, Dunja R.
dc.creatorPavlović, Ivan
dc.creatorStefanović, Aleksandra
dc.creatorProstran, Milica
dc.creatorIlić, Tihomir V.
dc.creatorStojanov, Marina
dc.date.accessioned2019-12-26T11:05:29Z
dc.date.available2019-12-26T11:05:29Z
dc.date.issued2019
dc.identifier.issn0042-8450
dc.identifier.urihttp://vinar.vin.bg.ac.rs/handle/123456789/8407
dc.description.abstractBackgroun / Aim. Constant production of free radicals and antioxidants (AO) in the cell is a part of normal cellular function. Their imbalance might take a part in pathophysiology of many diseases, including Parkinson’s disease (PD). Evaluation of the disease status, prooxidant-antioxidant balance (PAB) and antioxidants are being widely estimated. The aim of this study was to examine potential interaction between several AO variables (GSH, SOD, CAT and PAB) and clinicopathological features of patients with PD, particularly Hoehn and Yahr (H&Y) stage. Methods. A multivariate analysis of variance (MANOVA) was conducted to test the hypothesis of the mean differences between clinicopathological characteristics (gender, age at examination, duration of the disease, and H&Y stage) and AO variables, compared with age/sex matched healthy controls. The study included 91 patients with idiopatic PD patients and 20 healthy controls. Results. The multivariate effect size was estimated at 0.269, p <0.001, implying that 27.0% of the variance of the dependent variables was accounted for H&Y stage. Univariate tests showed that there were significant differences (p <0.001) across the H&Y stage on all AO variables. The H&Y stage remained significant predictor after controlling for the second variable, the disease duration (p <0.001, η2 = 0.249), and there were still significant differences across the H&Y stage on all variables, with effect size ( η2) ranging from 0.132, p =0.011 (lnGSH) to the still high values of 0.535 (lnPAB), 0.627 (lnSOD) and 0.964 (lnCAT). Conclusion. The results indicate that higher level of oxidative stress in blood of PD patients is possibly related to PD stage. Along with reduction of SOD and GSH level, CAT activity was elevated in comparison to healthy subjects. Furthermore, Pwas shifted toward oxidative stress.en
dc.language.isoen
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175023/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173044/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41014/RS//
dc.rightsopenAccess
dc.rights.urihttps://creativecommons.org/licenses/by-sa/4.0/
dc.sourceVojnosanitetski pregleden
dc.subjectparkinson diseaseen
dc.subjectsuperoxide dismutaseen
dc.subjectcatalaseen
dc.subjectglutathioneen
dc.subjectprooxidant-antioxidant balanceen
dc.titleAntioxidant status and clinicopathological parameters in patients with Parkinson's diseaseen
dc.title.alternativeAntioksidativni status i kliničko-patološki parametri kod obolelih od Parkinsonove bolestisr
dc.typearticleen
dc.rights.licenseBY-SA
dcterms.abstractПавловић, Иван; Простран, Милица; Стефановић, Aлександра; Пејић, Снежана; Стојанов, Марина; Милетић-Вукајловић, Јадранка; Валента Шобот, Aна; Дракулић, Дуња; Илић, Тихомир; Тодоровић, Aна;
dc.citation.volume77
dc.citation.issue7
dc.citation.spage724
dc.citation.epage730
dc.identifier.wos000560134500008
dc.identifier.doi10.2298/VSP180718148M
dc.citation.rankM23
dc.type.versionpublishedVersion
dc.identifier.scopus2-s2.0-85078257861
dc.identifier.fulltexthttp://vinar.vin.bg.ac.rs/bitstream/id/21728/0042-84501800148M.pdf


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