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dc.contributor.editorBartholomew, Ibeh
dc.creatorGavrilović, Ljubica
dc.creatorStojiljković, Vesna
dc.creatorPopović, Nataša M.
dc.creatorPejić, Snežana
dc.creatorTodorović, Ana
dc.creatorPavlović, Ivan
dc.creatorPajović, Snežana B.
dc.date.accessioned2019-12-26T10:41:00Z
dc.date.available2019-12-26T10:41:00Z
dc.date.issued2018
dc.identifier.isbn978-1-78923-164-9
dc.identifier.isbn978-1-78923-165-6
dc.identifier.urihttp://vinar.vin.bg.ac.rs/handle/123456789/8406
dc.description.abstractWe examined the effects of daily exercise on the gene expression of catecholamine biosynthetic enzymes (tyrosine hydroxylase (TH), dopamine-β-hydroxylase (DBH), and phenyl ethanolamine N-methyltransferase (PNMT)), vesicular monoamine transporter 2 (VMAT 2), antioxidant enzymes (superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx)), concentrations of catecholamines (noradrenaline (NA) and adrenaline (A)) and malondialdehyde (MDA), activities of monoamine oxidase (MAO), and antioxidant enzymes in the spleen of chronically psychosocially stressed rats. Exposure of chronically stressed rats to exercise increased the levels of PNMT protein by 19%, VMAT 2 mRNA by 100%, NA by 160%, and A by 140%; decreased/unchanged MAO enzyme activity; returned concentrations of MDA to control level; and increased CAT and GPx mRNA levels (50% and 150%, respectively). Exercise induced the accumulation of the catecholamines and a decrease of stress-induced oxidative stress in the spleen, which may significantly affect the immune-neuroendocrine interactions in stress conditions. Also, exercise induced the catecholaminergic system and antioxidant defense to become more ready to a novel stressor, which indicates that exercise may induce potentially positive physiological adaptations. Our combined model of chronic social isolation and long-term daily treadmill running in rats may be a good animal model in the research of therapeutic role of exercise in human disease caused by chronic stress.en
dc.language.isoen
dc.publisherIntechOpenen
dc.publisherInTechen
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41027/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41022/RS//
dc.relation.ispartofExperimental Animal Models of Human Diseases - An Effective Therapeutic Strategy
dc.rightsopenAccess
dc.sourceExperimental Animal Models of Human Diseases : An Effective Therapeutic Strategy, (ed.) Bartholomew Ibeh
dc.subjecttreadmill runningen
dc.subjectchronic social isolationen
dc.subjectcatecholamineen
dc.subjectantioxidant enzymesen
dc.subjectspleenen
dc.subjectratsen
dc.titleAnimal Models for Chronic Stress-Induced Oxidative Stress in the Spleen: The Role of Exercise and Catecholaminergic Systemen
dc.typebookParten
dc.rights.licenseBY
dcterms.abstractТодоровић, Aна; Павловић, Иван; Пајовић, Снежана Б.; Гавриловић, Љубица; Стојиљковић, Весна; Поповић, Наташа М.; Пејић, Снежана;
dc.rights.holder© 2018 The Author(s)
dc.citation.issueCh. 14
dc.citation.spage283
dc.citation.epage310
dc.identifier.doi10.5772/intechopen.70008
dc.description.otherChapter of Experimental Animal Models of Human Diseases : An Effective Therapeutic Strategy / Edited by Bartholomew Ibeh. [http://dx.doi.org/10.5772/66030]
dc.type.versionpublishedVersion
dc.identifier.fulltexthttp://vinar.vin.bg.ac.rs/bitstream/id/20888/56420.pdf


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