The effect of antioxidant status on overall survival in renal cell carcinoma
Popović, Nataša M.
Pajović, Snežana B.
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Introduction The oxidative stress contributes to all three phases of carcinogenesis and represents a concomitant condition in renal cell carcinoma (RCC). RCC is the most common type of neoplasm of the kidney, and despite numerous studies the set of predictive and prognostic markers of survival are still unknown. The aim of our study was to examine the relation between antioxidant (AO) status and overall survival (OS) in RCC patients. Material and methods Our study included 95 patients with RCC, who underwent radical nephrectomy. We analysed the prognostic role of antioxidant enzymes (superoxide dismutase, catalase, glutathione peroxidase, glutathione S-transferase, glutathione reductase, glutathione, and malondialde-hyde) and other clinicopathological factors (size, grade, stage, and histological subtype) on the OS of RCC patients. Results The 5-year OS was 54.6%. The survival analysis related to AO parameters showed no significant difference in survival of RCC patients. The concentr...ation of malondialdehyde, an indicator of lipid peroxidation, also had no significant effect on the survival rate of RCC pa-tients. Univariate and multivariate analysis confirmed the significance of clinicopathological parameters (size, p < 0.001; Fuhrman grade, p = 0.001, and stage, p < 0.001) for patients’ survival. Conclusions In our cohort of patients, different antioxidant parameters were not found to be predictors for OS of patients with RCC, who underwent radical nephrectomy.
Keywords:renal cell carcinoma / oxidative stress / overall survival / prospective study
Source:Archives of Medical Science, 2020, 16, 1, 94-101
- Cellular and molecular basis of malignant and cardiovascular diseases-clinical implications (RS-41027)
Pavlović I, Pejić S, Radojević-Škodrić S, Todorović A, Stojiljković V, Gavrilović L, Popović NM, Basta-Jovanović G, Džamić Z, Pajović SB. The effect of antioxidant status on overall survival in renal cell carcinoma. Archives of Medical Science. 2020;16(1):94-101
Pavlović, I., Pejić, S., Radojević-Škodrić, S., Todorović, A., Stojiljković, V., Gavrilović, L., Popović, N. M., Basta-Jovanović, G., Džamić, Z.,& Pajović, S. B. (2020). The effect of antioxidant status on overall survival in renal cell carcinoma. Archives of Medical Science, 16(1), 94-101. https://doi.org/10.5114/aoms.2019.86818
Pavlović Ivan, Pejić Snežana, Radojević-Škodrić Sanja, Todorović Ana, Stojiljković Vesna, Gavrilović Ljubica, Popović Nataša M., Basta-Jovanović Gordana, Džamić Zoran, Pajović Snežana B., "The effect of antioxidant status on overall survival in renal cell carcinoma" 16, no. 1 (2020):94-101, https://doi.org/10.5114/aoms.2019.86818 .