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dc.creatorPopović, Nataša M.
dc.creatorPajović, Snežana B.
dc.creatorStojiljković, Vesna
dc.creatorTodorović, Ana
dc.creatorPejić, Snežana
dc.creatorPavlović, Ivan
dc.creatorGavrilović, Ljubica
dc.date.accessioned2019-12-26T10:23:13Z
dc.date.available2019-12-26T10:23:13Z
dc.date.issued2018
dc.identifier.issn0090-2977
dc.identifier.urihttp://vinar.vin.bg.ac.rs/handle/123456789/8404
dc.description.abstractThe effects of chronic restraint stress (CRS, 2 h during 14 days) on gene expression of tyrosine hydroxylase (TH), catechol-O-methyltransferase (COMT), and glutathione peroxidase (GPx) were studied in the rat hippocampus. Changes in the dopamine (DA) concentration and activities of monoamine oxidases (MAO A and MAO B) and GPx in this cerebral structure of chronically stressed rats were also examined. The investigated parameters were quantified using real-time RT-PCR, Western blot analyses, and assay of enzymatic activity. We found that CRS decreased the TH protein level and DA concentration, which probably confirms the statement that de novo synthesis of DA is suppressed under stress conditions. The increased activities of MAO B, as well as the increased level of COMT protein, are believed to be related to intensified DA catabolism conditions. Also, a decreased activity of GPx in the hippocampus of chronically stressed animals was found. The increased enzymatic activity of MAO B negatively correlated with the reduced activity of GPx under the above-mentioned stress conditions. These events in the hippocampus of chronically stressed animals could synergistically cause oxidative damage to the mitochondria. © 2019, Springer Science+Business Media, LLC, part of Springer Nature.en
dc.language.isoen
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41027/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173041/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41022/RS//
dc.rightsrestrictedAccess
dc.sourceNeurophysiology
dc.subjectdopamineen
dc.subjectglutathione peroxidaseen
dc.subjectchronic restraint stressen
dc.subjecthippocampusen
dc.subjectgene expressionen
dc.titleActivities of the Dopaminergic System and Glutathione Antioxidant System in the Hippocampus of Stressed ratsen
dc.typearticleen
dc.rights.licenseARR
dcterms.abstractПоповић, Наташа М.; Павловић, Иван; Пајовић, Снежана Б.; Тодоровић, Aна; Пејић, Снежана; Гавриловић, Љубица; Стојиљковић, Весна;
dc.rights.holder© 2019, Springer Science+Business Media, LLC, part of Springer Nature
dc.citation.volume50
dc.citation.issue5
dc.citation.spage332
dc.citation.epage338
dc.identifier.wos000460031200003
dc.identifier.doi10.1007/s11062-019-09758-z
dc.citation.rankM23
dc.type.versionpublishedVersion
dc.identifier.scopus2-s2.0-85060684507


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