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dc.creatorEssack, Magbubah
dc.creatorSalhi, Adil
dc.creatorStanimirović, Julijana
dc.creatorTifratene, Faroug
dc.creatorBin Raies, Arwa
dc.creatorHungler, Arnaud
dc.creatorUludag, Mahmut
dc.creatorVan Neste, Christophe
dc.creatorTrpković, Andreja
dc.creatorBajić, Vladan P.
dc.creatorBajić, Vladimir B.
dc.creatorIsenović, Esma R.
dc.date.accessioned2019-12-09T13:27:18Z
dc.date.available2019-12-09T13:27:18Z
dc.date.issued2019
dc.identifier.issn1942-0900 (print)
dc.identifier.issn1942-0994 (electronic)
dc.identifier.urihttp://vinar.vin.bg.ac.rs/handle/123456789/8389
dc.description.abstractIn cellular physiology and signaling, reactive oxygen species (ROS) play one of the most critical roles. ROS overproduction leads to cellular oxidative stress. This may lead to an irrecoverable imbalance of redox (oxidation-reduction reaction) function that deregulates redox homeostasis, which itself could lead to several diseases including neurodegenerative disease, cardiovascular disease, and cancers. In this study, we focus on the redox effects related to vascular systems in mammals. To support research in this domain, we developed an online knowledge base, DES-RedoxVasc, which enables exploration of information contained in the biomedical scientific literature. The DES-RedoxVasc system analyzed 233399 documents consisting of PubMed abstracts and PubMed Central full-text articles related to different aspects of redox biology in vascular systems. It allows researchers to explore enriched concepts from 28 curated thematic dictionaries, as well as literature-derived potential associations of pairs of such enriched concepts, where associations themselves are statistically enriched. For example, the system allows exploration of associations of pathways, diseases, mutations, genes/proteins, miRNAs, long ncRNAs, toxins, drugs, biological processes, molecular functions, etc. that allow for insights about different aspects of redox effects and control of processes related to the vascular system. Moreover, we deliver case studies about some existing or possibly novel knowledge regarding redox of vascular biology demonstrating the usefulness of DES-RedoxVasc. DES-RedoxVasc is the first compiled knowledge base using text mining for the exploration of this topic.en
dc.language.isoen
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173033/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173034/RS//
dc.relationKing Abdullah University of Science and Technology (KAUST) Base Research Fund [BAS/1/1606-01-01]
dc.relationKAUST Office of Sponsored Research (OSR) Award [FCC/1/1976-24-01]
dc.rightsopenAccess
dc.sourceOxidative Medicine and Cellular Longevity
dc.titleLiterature-Based Enrichment Insights into Redox Control of Vascular Biologyen
dc.typearticleen
dc.rights.licenseBY
dcterms.abstractБајић, Владан П.; Исеновић, Есма Р.; Станимировиц, Јулијана; Ван Несте, Цхристопхе; Бајић, Владимир Б.; Улудаг, Махмут; Хунглер, Aрнауд; Бин Раиес, Aрwа; Тифратене, Фароуг; Ессацк, Магбубах; Салхи, Aдил; Трпковић, Aндреја;
dc.rights.holder© 2019 Magbubah Essack et al.
dc.citation.volume2019
dc.citation.spage1769437
dc.identifier.wos000469250000001
dc.identifier.doi10.1155/2019/1769437
dc.identifier.pmid31223421
dc.type.versionpublishedVersion
dc.identifier.scopus2-s2.0-85068493861
dc.identifier.fulltexthttp://vinar.vin.bg.ac.rs/bitstream/id/20883/Essack_2019_Literature-Based_Enrichment.pdf


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