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dc.creatorGluvić, Zoran
dc.creatorSudar-Milovanović, Emina
dc.creatorSamardžić, Vladimir S.
dc.creatorObradović, Milan M.
dc.creatorJevremović, Danimir P.
dc.creatorRadenković, Saša P.
dc.creatorIsenović, Esma R.
dc.date.accessioned2019-11-28T08:49:38Z
dc.date.available2019-11-28T08:49:38Z
dc.date.issued2019
dc.identifier.issn0306-9877 (print)
dc.identifier.issn1532-2777 (electronic)
dc.identifier.urihttp://vinar.vin.bg.ac.rs/handle/123456789/8369
dc.description.abstractPrimary hypothyroidism can affect lipid metabolism, cardiovascular (CV) function, and overall patients’ quality of life (QoL). Decrease in serum nitric oxide (NO) levels could promote the atherosclerosis acceleration in hypothyroid patients. Our hypothesis is that serum NO level is altered in hypothyroidism; more specifically, we hypothesize that the early vascular changes that can be observed in hypothyroidism could be due to these alterations and that serum NO levels are associated with lipid levels in female patients diagnosed with subclinical hypothyroidism (SCH) or clinical hypothyroidism (CH). Furthermore, since serum NO level is an early marker of atherosclerosis and related CV disorders, which are commonly present and follow hypothyreosis and greatly contribute to overall QoL, we further hypothesized that NO level would correlate with Thyroid Symptom Questionnaire (TSQ) and General Health Questionnaire 12 (GHQ12) scores in hypothyroid patients. A collaterally of our hypothesis was that levothyroxine (LT4) treatment would affect serum NO levels as well as TSQ and GHQ12 scores. Therefore, we have analyzed lipid profile, the level of NO and QoL scores in female patients diagnosed with SCH and CH in order to determine the correlation between NO and generic and thyroid disease symptoms in treatment naïve SCH and CH patients and after LT4 treatment and laboratory euthyroidism achievement. As a consequence of our hypothesis is that measurement of serum NO level in SCH and CH patients may be an innovative way to improve LT4 treatment efficacy. This assumption could have a practical significance for future investigations regarding the management of hypothyroidism treatment protocols in current guidelines. © 2019 Elsevier Ltden
dc.language.isoen
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173033/RS//
dc.rightsrestrictedAccess
dc.sourceMedical Hypotheses
dc.subjectHypothyroidismen
dc.subjectNitric oxideen
dc.subjectLevothyroxineen
dc.subjectQuality of lifeen
dc.titleSerum nitric oxide levels correlate with quality of life questionnaires scores of hypothyroid femalesen
dc.typearticleen
dc.rights.licenseARR
dcterms.abstractРаденковић, Саша П.; Обрадовић, Милан М.; Исеновић, Есма Р.; Глувић, Зоран М.; Судар-Миловановић, Емина М.; Самарджић, Владимир С.; Јевремовић, Данимир П.;
dc.rights.holder© 2019 Elsevier Ltd
dc.citation.volume131
dc.citation.spage109299
dc.identifier.wos000484646200003
dc.identifier.doi10.1016/j.mehy.2019.109299
dc.identifier.pmid31443778
dc.type.versionpublishedVersion
dc.identifier.scopus2-s2.0-85068377510


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