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Melatonin treatment affects changes in adrenal gene expression of catecholamine biosynthesizing enzymes and norepinephrine transporter in the rat model of chronic-stress-induced depression

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Authors
Stefanović, Bojana
Spasojević, Nataša
Jovanović, Predrag
Dronjak, Slađana
Article (Published version)
,
© 2019, Published by NRC Research Press
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Abstract
This study investigated the effects of melatonin treatment on adrenal catecholamine content, synthesis, uptake, and vesicular transport induced by the chronic unpredictable mild stress (CUMS) model of depression in rats. This entailed quantifying the norepinephrine, epinephrine, mRNA, and protein levels of tyrosine hydroxylase (TH), dopamine-β-hydroxylase (DBH), phenylethanolamine N-methyltransferase (PNMT), norepinephrine transporter (NET), and vesicular monoamine transporter 2 (VMAT2) in the adrenal medulla. CUMS caused a significant depletion of norepinephrine stores and protein levels of TH, DBH, and NET, whereas the gene expression of PNMT was increased. It was observed that melatonin treatment in the CUMS rats prevented the stress-induced decrease in norepinephrine content and the protein expression of TH, DBH, and NET in the adrenal medulla of chronically stressed rats. The present study demonstrates the stimulatory effect of melatonin on adrenomedullary synthesis, the uptake an...d content of catecholamine in the rat model of chronic stress-induced depression. © 2019, Published by NRC Research Press.

Keywords:
depression / melatonin / adrenal medulla / catecholamines / enzymes / transporters
Source:
Canadian Journal of Physiology and Pharmacology, 2019, 97, 7, 685-690
Funding / projects:
  • Molecular mechanisms of cellular responses on pathological changes in central neuronal system and peripheral organs of mammals (RS-173044)
Note:
  • Peer-review version of the article available at: http://vinar.vin.bg.ac.rs/handle/123456789/8410

DOI: 10.1139/cjpp-2018-0612

ISSN: 0008-4212

PubMed: 30773040

WoS: 000472624400011

Scopus: 2-s2.0-85067946719
[ Google Scholar ]
12
10
URI
https://vinar.vin.bg.ac.rs/handle/123456789/8361
Collections
  • Radovi istraživača
Institution/Community
Vinča
TY  - JOUR
AU  - Stefanović, Bojana
AU  - Spasojević, Nataša
AU  - Jovanović, Predrag
AU  - Dronjak, Slađana
PY  - 2019
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/8361
AB  - This study investigated the effects of melatonin treatment on adrenal catecholamine content, synthesis, uptake, and vesicular transport induced by the chronic unpredictable mild stress (CUMS) model of depression in rats. This entailed quantifying the norepinephrine, epinephrine, mRNA, and protein levels of tyrosine hydroxylase (TH), dopamine-β-hydroxylase (DBH), phenylethanolamine N-methyltransferase (PNMT), norepinephrine transporter (NET), and vesicular monoamine transporter 2 (VMAT2) in the adrenal medulla. CUMS caused a significant depletion of norepinephrine stores and protein levels of TH, DBH, and NET, whereas the gene expression of PNMT was increased. It was observed that melatonin treatment in the CUMS rats prevented the stress-induced decrease in norepinephrine content and the protein expression of TH, DBH, and NET in the adrenal medulla of chronically stressed rats. The present study demonstrates the stimulatory effect of melatonin on adrenomedullary synthesis, the uptake and content of catecholamine in the rat model of chronic stress-induced depression. © 2019, Published by NRC Research Press.
T2  - Canadian Journal of Physiology and Pharmacology
T1  - Melatonin treatment affects changes in adrenal gene expression of catecholamine biosynthesizing enzymes and norepinephrine transporter in the rat model of chronic-stress-induced depression
VL  - 97
IS  - 7
SP  - 685
EP  - 690
DO  - 10.1139/cjpp-2018-0612
ER  - 
@article{
author = "Stefanović, Bojana and Spasojević, Nataša and Jovanović, Predrag and Dronjak, Slađana",
year = "2019",
abstract = "This study investigated the effects of melatonin treatment on adrenal catecholamine content, synthesis, uptake, and vesicular transport induced by the chronic unpredictable mild stress (CUMS) model of depression in rats. This entailed quantifying the norepinephrine, epinephrine, mRNA, and protein levels of tyrosine hydroxylase (TH), dopamine-β-hydroxylase (DBH), phenylethanolamine N-methyltransferase (PNMT), norepinephrine transporter (NET), and vesicular monoamine transporter 2 (VMAT2) in the adrenal medulla. CUMS caused a significant depletion of norepinephrine stores and protein levels of TH, DBH, and NET, whereas the gene expression of PNMT was increased. It was observed that melatonin treatment in the CUMS rats prevented the stress-induced decrease in norepinephrine content and the protein expression of TH, DBH, and NET in the adrenal medulla of chronically stressed rats. The present study demonstrates the stimulatory effect of melatonin on adrenomedullary synthesis, the uptake and content of catecholamine in the rat model of chronic stress-induced depression. © 2019, Published by NRC Research Press.",
journal = "Canadian Journal of Physiology and Pharmacology",
title = "Melatonin treatment affects changes in adrenal gene expression of catecholamine biosynthesizing enzymes and norepinephrine transporter in the rat model of chronic-stress-induced depression",
volume = "97",
number = "7",
pages = "685-690",
doi = "10.1139/cjpp-2018-0612"
}
Stefanović, B., Spasojević, N., Jovanović, P.,& Dronjak, S.. (2019). Melatonin treatment affects changes in adrenal gene expression of catecholamine biosynthesizing enzymes and norepinephrine transporter in the rat model of chronic-stress-induced depression. in Canadian Journal of Physiology and Pharmacology, 97(7), 685-690.
https://doi.org/10.1139/cjpp-2018-0612
Stefanović B, Spasojević N, Jovanović P, Dronjak S. Melatonin treatment affects changes in adrenal gene expression of catecholamine biosynthesizing enzymes and norepinephrine transporter in the rat model of chronic-stress-induced depression. in Canadian Journal of Physiology and Pharmacology. 2019;97(7):685-690.
doi:10.1139/cjpp-2018-0612 .
Stefanović, Bojana, Spasojević, Nataša, Jovanović, Predrag, Dronjak, Slađana, "Melatonin treatment affects changes in adrenal gene expression of catecholamine biosynthesizing enzymes and norepinephrine transporter in the rat model of chronic-stress-induced depression" in Canadian Journal of Physiology and Pharmacology, 97, no. 7 (2019):685-690,
https://doi.org/10.1139/cjpp-2018-0612 . .

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