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Complex formation equilibria between aluminum(III), gadolinium(III) and yttrium(III) ions and some fluoroquinolone ligands. Potentiometric and spectroscopic study

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2015
Authors
Jakovljević, Ivan
Petrović, Đorđe
Joksović, Ljubinka G.
Lazarević, Ivan
Jelikić-Stankov, Milena
Đurđević, Predrag
Article (Published version)
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Abstract
Complex formation equilibria of aluminum(III), gadolinium(III), and yttrium(III) ions with the fluoroquinolone antibacterials moxifloxacin, ofloxacin, fleroxacin, lomefloxacin, levofloxacin, and ciprofloxacin were studied in aqueous solution by potentiometric and spectroscopic methods. The identity and stability of metal-fluoroquinolone complexes were determined by analyzing potentiometric titration curves (310K, =0.15M NaCl, pH range=2-11, C-L/C-M=1:1 to 3:1, C-M=1.0mM) with the aid of Hyperquad2006 program. The main species formed in the system may be formulated as MpHqLr (p=1, q=-2 to 2, r=1-3, L=fluoroquinolone anion, logarithm of overall stability constant, log (p,q,r)=in the range ca. -10 to 45). The stability of complexes is mostly influenced by metal ion properties (ionization potential, ionic radius) indicating partial ionic character of the coordination bond. The complexes were also characterized by spectroscopic measurements: spectrofluorimetry, H-1-NMR, and ESI-MS. Fluorime...tric data were evaluated with the aid of HypSpec2014 and indicated the formation of MLr (r=1-3) complexes with cumulative conditional stability constants significantly lower than the thermodynamic ones. NMR and MS data corroborate potentiometrically determined speciation. Calculated plasma mobilizing capacity of the ligands generally follows the order levofloxacin GT moxifloxacin GT ciprofloxacin at concentration levels of the ligands higher or equal to ca. 10(-4)M.

Keywords:
Complexes / Aqueous equilibria / Fluoroquinolones / Aluminum / Gadolinium / Yttrium / Bio-speciation
Source:
Journal of Coordination Chemistry, 2015, 68, 24, 4272-4295
Publisher:
  • Taylor & Francis
Funding / projects:
  • Synthesis, modeling, physicochemical and biological properties of organic compounds and related metal complexes (RS-172016)

DOI: 10.1080/00958972.2015.1089535

ISSN: 0095-8972; 1029-0389

WoS: 000365654700003

Scopus: 2-s2.0-84948443949
[ Google Scholar ]
5
4
URI
https://vinar.vin.bg.ac.rs/handle/123456789/833
Collections
  • WoS Import
Institution/Community
Vinča
TY  - JOUR
AU  - Jakovljević, Ivan
AU  - Petrović, Đorđe
AU  - Joksović, Ljubinka G.
AU  - Lazarević, Ivan
AU  - Jelikić-Stankov, Milena
AU  - Đurđević, Predrag
PY  - 2015
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/833
AB  - Complex formation equilibria of aluminum(III), gadolinium(III), and yttrium(III) ions with the fluoroquinolone antibacterials moxifloxacin, ofloxacin, fleroxacin, lomefloxacin, levofloxacin, and ciprofloxacin were studied in aqueous solution by potentiometric and spectroscopic methods. The identity and stability of metal-fluoroquinolone complexes were determined by analyzing potentiometric titration curves (310K, =0.15M NaCl, pH range=2-11, C-L/C-M=1:1 to 3:1, C-M=1.0mM) with the aid of Hyperquad2006 program. The main species formed in the system may be formulated as MpHqLr (p=1, q=-2 to 2, r=1-3, L=fluoroquinolone anion, logarithm of overall stability constant, log (p,q,r)=in the range ca. -10 to 45). The stability of complexes is mostly influenced by metal ion properties (ionization potential, ionic radius) indicating partial ionic character of the coordination bond. The complexes were also characterized by spectroscopic measurements: spectrofluorimetry, H-1-NMR, and ESI-MS. Fluorimetric data were evaluated with the aid of HypSpec2014 and indicated the formation of MLr (r=1-3) complexes with cumulative conditional stability constants significantly lower than the thermodynamic ones. NMR and MS data corroborate potentiometrically determined speciation. Calculated plasma mobilizing capacity of the ligands generally follows the order levofloxacin GT moxifloxacin GT ciprofloxacin at concentration levels of the ligands higher or equal to ca. 10(-4)M.
PB  - Taylor & Francis
T2  - Journal of Coordination Chemistry
T1  - Complex formation equilibria between aluminum(III), gadolinium(III) and yttrium(III) ions and some fluoroquinolone ligands. Potentiometric and spectroscopic study
VL  - 68
IS  - 24
SP  - 4272
EP  - 4295
DO  - 10.1080/00958972.2015.1089535
ER  - 
@article{
author = "Jakovljević, Ivan and Petrović, Đorđe and Joksović, Ljubinka G. and Lazarević, Ivan and Jelikić-Stankov, Milena and Đurđević, Predrag",
year = "2015",
abstract = "Complex formation equilibria of aluminum(III), gadolinium(III), and yttrium(III) ions with the fluoroquinolone antibacterials moxifloxacin, ofloxacin, fleroxacin, lomefloxacin, levofloxacin, and ciprofloxacin were studied in aqueous solution by potentiometric and spectroscopic methods. The identity and stability of metal-fluoroquinolone complexes were determined by analyzing potentiometric titration curves (310K, =0.15M NaCl, pH range=2-11, C-L/C-M=1:1 to 3:1, C-M=1.0mM) with the aid of Hyperquad2006 program. The main species formed in the system may be formulated as MpHqLr (p=1, q=-2 to 2, r=1-3, L=fluoroquinolone anion, logarithm of overall stability constant, log (p,q,r)=in the range ca. -10 to 45). The stability of complexes is mostly influenced by metal ion properties (ionization potential, ionic radius) indicating partial ionic character of the coordination bond. The complexes were also characterized by spectroscopic measurements: spectrofluorimetry, H-1-NMR, and ESI-MS. Fluorimetric data were evaluated with the aid of HypSpec2014 and indicated the formation of MLr (r=1-3) complexes with cumulative conditional stability constants significantly lower than the thermodynamic ones. NMR and MS data corroborate potentiometrically determined speciation. Calculated plasma mobilizing capacity of the ligands generally follows the order levofloxacin GT moxifloxacin GT ciprofloxacin at concentration levels of the ligands higher or equal to ca. 10(-4)M.",
publisher = "Taylor & Francis",
journal = "Journal of Coordination Chemistry",
title = "Complex formation equilibria between aluminum(III), gadolinium(III) and yttrium(III) ions and some fluoroquinolone ligands. Potentiometric and spectroscopic study",
volume = "68",
number = "24",
pages = "4272-4295",
doi = "10.1080/00958972.2015.1089535"
}
Jakovljević, I., Petrović, Đ., Joksović, L. G., Lazarević, I., Jelikić-Stankov, M.,& Đurđević, P.. (2015). Complex formation equilibria between aluminum(III), gadolinium(III) and yttrium(III) ions and some fluoroquinolone ligands. Potentiometric and spectroscopic study. in Journal of Coordination Chemistry
Taylor & Francis., 68(24), 4272-4295.
https://doi.org/10.1080/00958972.2015.1089535
Jakovljević I, Petrović Đ, Joksović LG, Lazarević I, Jelikić-Stankov M, Đurđević P. Complex formation equilibria between aluminum(III), gadolinium(III) and yttrium(III) ions and some fluoroquinolone ligands. Potentiometric and spectroscopic study. in Journal of Coordination Chemistry. 2015;68(24):4272-4295.
doi:10.1080/00958972.2015.1089535 .
Jakovljević, Ivan, Petrović, Đorđe, Joksović, Ljubinka G., Lazarević, Ivan, Jelikić-Stankov, Milena, Đurđević, Predrag, "Complex formation equilibria between aluminum(III), gadolinium(III) and yttrium(III) ions and some fluoroquinolone ligands. Potentiometric and spectroscopic study" in Journal of Coordination Chemistry, 68, no. 24 (2015):4272-4295,
https://doi.org/10.1080/00958972.2015.1089535 . .

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