Benefits of L-Arginine on Cardiovascular System
Authorized Users Only
2016
Authors
Sudar-Milovanović, EminaObradović, Milan M.
Jovanović, Aleksandra
Zarić, Božidarka
Zafirović, Sonja
Panić, Anastasija
Radak, Đorđe J.
Isenović, Esma R.
Article (Published version)
,
Bentham Science Publishers
Metadata
Show full item recordAbstract
The amino acid, L-Arginine (L-Arg) plays an important role in the cardiovascular system. Data from the literature show that L-Arg is the only substrate for the production of nitric oxide (NO), from which L-Arg develops its effects on the cardiovascular system. As a free radical, NO is synthesized in all mammalian cells by L-Arg with the activity of NO synthase (NOS). In states of hypertension, diabetes, hypercholesterolemia and vascular inflammation a disorder occurs in the metabolic pathway of the synthesis of NO from L-Arg which all together bring alterations of blood vessels. Experimental results obtained on animals, as well as clinical studies show that L-Arg has an effect on thrombocytes, on the process of coagulation and on the fibrolytic system. This mini review represents a summary of the latest scientific animal and human studies related to L-Arg and its mechanisms of actions with a focus on the role of L-Arg via NO pathway in cardiovascular disorders. Moreover, here we presen...t data from recent animal and clinical studies suggesting that L-Arg could be one of the possible therapeutic molecules for improving the treatment of different cardiovascular disorders.
Keywords:
Amino acid / Arginase / cardiovascular system / cardiovascular disorders / L-Arg / NO / NOSSource:
Mini Reviews in Medicinal Chemistry, 2016, 16, 2, 94-103Publisher:
- Bentham Science Publishers
Funding / projects:
- Hormonal regulation of expression and activity of the nitric oxide synthase and sodium-potassium pump in experimental models of insulin resistance, diabetes and cardiovascular disorders (RS-MESTD-Basic Research (BR or ON)-173033)
- Carotid disease in Serbia - pathologic dynamics, prevention, diagnostics and inovative therapeutic methods (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-41002)
DOI: 10.2174/1389557515666151016125826
ISSN: 1389-5575; 1875-5607
PubMed: 26471966
WoS: 000365468300003
Scopus: 2-s2.0-84949816844
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Institution/Community
VinčaTY - JOUR AU - Sudar-Milovanović, Emina AU - Obradović, Milan M. AU - Jovanović, Aleksandra AU - Zarić, Božidarka AU - Zafirović, Sonja AU - Panić, Anastasija AU - Radak, Đorđe J. AU - Isenović, Esma R. PY - 2016 UR - https://vinar.vin.bg.ac.rs/handle/123456789/829 AB - The amino acid, L-Arginine (L-Arg) plays an important role in the cardiovascular system. Data from the literature show that L-Arg is the only substrate for the production of nitric oxide (NO), from which L-Arg develops its effects on the cardiovascular system. As a free radical, NO is synthesized in all mammalian cells by L-Arg with the activity of NO synthase (NOS). In states of hypertension, diabetes, hypercholesterolemia and vascular inflammation a disorder occurs in the metabolic pathway of the synthesis of NO from L-Arg which all together bring alterations of blood vessels. Experimental results obtained on animals, as well as clinical studies show that L-Arg has an effect on thrombocytes, on the process of coagulation and on the fibrolytic system. This mini review represents a summary of the latest scientific animal and human studies related to L-Arg and its mechanisms of actions with a focus on the role of L-Arg via NO pathway in cardiovascular disorders. Moreover, here we present data from recent animal and clinical studies suggesting that L-Arg could be one of the possible therapeutic molecules for improving the treatment of different cardiovascular disorders. PB - Bentham Science Publishers T2 - Mini Reviews in Medicinal Chemistry T1 - Benefits of L-Arginine on Cardiovascular System VL - 16 IS - 2 SP - 94 EP - 103 DO - 10.2174/1389557515666151016125826 ER -
@article{ author = "Sudar-Milovanović, Emina and Obradović, Milan M. and Jovanović, Aleksandra and Zarić, Božidarka and Zafirović, Sonja and Panić, Anastasija and Radak, Đorđe J. and Isenović, Esma R.", year = "2016", abstract = "The amino acid, L-Arginine (L-Arg) plays an important role in the cardiovascular system. Data from the literature show that L-Arg is the only substrate for the production of nitric oxide (NO), from which L-Arg develops its effects on the cardiovascular system. As a free radical, NO is synthesized in all mammalian cells by L-Arg with the activity of NO synthase (NOS). In states of hypertension, diabetes, hypercholesterolemia and vascular inflammation a disorder occurs in the metabolic pathway of the synthesis of NO from L-Arg which all together bring alterations of blood vessels. Experimental results obtained on animals, as well as clinical studies show that L-Arg has an effect on thrombocytes, on the process of coagulation and on the fibrolytic system. This mini review represents a summary of the latest scientific animal and human studies related to L-Arg and its mechanisms of actions with a focus on the role of L-Arg via NO pathway in cardiovascular disorders. Moreover, here we present data from recent animal and clinical studies suggesting that L-Arg could be one of the possible therapeutic molecules for improving the treatment of different cardiovascular disorders.", publisher = "Bentham Science Publishers", journal = "Mini Reviews in Medicinal Chemistry", title = "Benefits of L-Arginine on Cardiovascular System", volume = "16", number = "2", pages = "94-103", doi = "10.2174/1389557515666151016125826" }
Sudar-Milovanović, E., Obradović, M. M., Jovanović, A., Zarić, B., Zafirović, S., Panić, A., Radak, Đ. J.,& Isenović, E. R.. (2016). Benefits of L-Arginine on Cardiovascular System. in Mini Reviews in Medicinal Chemistry Bentham Science Publishers., 16(2), 94-103. https://doi.org/10.2174/1389557515666151016125826
Sudar-Milovanović E, Obradović MM, Jovanović A, Zarić B, Zafirović S, Panić A, Radak ĐJ, Isenović ER. Benefits of L-Arginine on Cardiovascular System. in Mini Reviews in Medicinal Chemistry. 2016;16(2):94-103. doi:10.2174/1389557515666151016125826 .
Sudar-Milovanović, Emina, Obradović, Milan M., Jovanović, Aleksandra, Zarić, Božidarka, Zafirović, Sonja, Panić, Anastasija, Radak, Đorđe J., Isenović, Esma R., "Benefits of L-Arginine on Cardiovascular System" in Mini Reviews in Medicinal Chemistry, 16, no. 2 (2016):94-103, https://doi.org/10.2174/1389557515666151016125826 . .