Evaluation of early radiation DNA damage in a fractal cell nucleus model using Geant4-DNA
Samo za registrovane korisnike
2019
Autori
Sakata, DousatsuLampe, Nathanael
Karamitros, Mathieu
Kyriakou, Ioanna
Belov, Oleg
Bernal, Mario A
Bolst, David
Bordage, Marie-Claude
Breton, Vincent
Brown, Jeremy M.C.
Francis, Ziad
Ivanchenko, Vladimir
Meylan, Sylvain
Murakami, Koichi
Okada, Shogo
Petrović, Ivan M.
Ristić-Fira, Aleksandra
Santin, Giovanni
Sarramia, David
Sasaki, Takashi
Shin, Wook-Geun
Tang, Nicolas
Tran, Hoang N
Villagrasa, Carmen
Emfietzoglou, Dimitris
Nieminen, Petteri
Guatelli, Susanna
Incerti, Sebastien
Članak u časopisu (Objavljena verzija)
,
© 2019 Associazione Italiana di Fisica Medica
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
The advancement of multidisciplinary research fields dealing with ionising radiation induced biological damage – radiobiology, radiation physics, radiation protection and, in particular, medical physics – requires a clear mechanistic understanding of how cellular damage is induced by ionising radiation. Monte Carlo (MC)simulations provide a promising approach for the mechanistic simulation of radiation transport and radiation chemistry, towards the in silico simulation of early biological damage. We have recently developed a fully integrated MC simulation that calculates early single strand breaks (SSBs)and double strand breaks (DSBs)in a fractal chromatin based human cell nucleus model. The results of this simulation are almost equivalent to past MC simulations when considering direct/indirect strand break fraction, DSB yields and fragment distribution. The simulation results agree with experimental data on DSB yields within 13.6% on average and fragment distributions agree within an ...average of 34.8%. © 2019 Associazione Italiana di Fisica Medica
Ključne reči:
Geant4-DNA / Monte Carlo simulation / DNA damageIzvor:
Physica Medica, 2019, 62, 152-157Finansiranje / projekti:
- CNRS PICS France - Greece [7340]
- CNRS PICS France - Greece [8235]
- CNRS PICS France - Serbia [8070]
- IdEx Bordeaux University - France International Post-doctorates program of the "France-Japan Particle Physics Laboratory" International Associated Laboratory
- IdEx Bordeaux University - France - International Doctorates program of the "France-Korea Particle Physics Laboratory" International Associated Laboratory (2017-2020)
- Australian Research Council [ARC DP170100967]
- ESA [4000112863/14/NL/HB]
- CNPq [306775/2015-8]
- FAPESP foundation in Brazil [2011/51594-2]
- FAPESP foundation in Brazil [2015/21873-8]
DOI: 10.1016/j.ejmp.2019.04.010
ISSN: 1120-1797; 1724-191X
PubMed: 31109825
WoS: 000469329200017
Scopus: 2-s2.0-85065792241
URI
https://linkinghub.elsevier.com/retrieve/pii/S1120179719300882https://vinar.vin.bg.ac.rs/handle/123456789/8206
Kolekcije
Institucija/grupa
VinčaTY - JOUR AU - Sakata, Dousatsu AU - Lampe, Nathanael AU - Karamitros, Mathieu AU - Kyriakou, Ioanna AU - Belov, Oleg AU - Bernal, Mario A AU - Bolst, David AU - Bordage, Marie-Claude AU - Breton, Vincent AU - Brown, Jeremy M.C. AU - Francis, Ziad AU - Ivanchenko, Vladimir AU - Meylan, Sylvain AU - Murakami, Koichi AU - Okada, Shogo AU - Petrović, Ivan M. AU - Ristić-Fira, Aleksandra AU - Santin, Giovanni AU - Sarramia, David AU - Sasaki, Takashi AU - Shin, Wook-Geun AU - Tang, Nicolas AU - Tran, Hoang N AU - Villagrasa, Carmen AU - Emfietzoglou, Dimitris AU - Nieminen, Petteri AU - Guatelli, Susanna AU - Incerti, Sebastien PY - 2019 UR - https://linkinghub.elsevier.com/retrieve/pii/S1120179719300882 UR - https://vinar.vin.bg.ac.rs/handle/123456789/8206 AB - The advancement of multidisciplinary research fields dealing with ionising radiation induced biological damage – radiobiology, radiation physics, radiation protection and, in particular, medical physics – requires a clear mechanistic understanding of how cellular damage is induced by ionising radiation. Monte Carlo (MC)simulations provide a promising approach for the mechanistic simulation of radiation transport and radiation chemistry, towards the in silico simulation of early biological damage. We have recently developed a fully integrated MC simulation that calculates early single strand breaks (SSBs)and double strand breaks (DSBs)in a fractal chromatin based human cell nucleus model. The results of this simulation are almost equivalent to past MC simulations when considering direct/indirect strand break fraction, DSB yields and fragment distribution. The simulation results agree with experimental data on DSB yields within 13.6% on average and fragment distributions agree within an average of 34.8%. © 2019 Associazione Italiana di Fisica Medica T2 - Physica Medica T1 - Evaluation of early radiation DNA damage in a fractal cell nucleus model using Geant4-DNA VL - 62 SP - 152 EP - 157 DO - 10.1016/j.ejmp.2019.04.010 ER -
@article{ author = "Sakata, Dousatsu and Lampe, Nathanael and Karamitros, Mathieu and Kyriakou, Ioanna and Belov, Oleg and Bernal, Mario A and Bolst, David and Bordage, Marie-Claude and Breton, Vincent and Brown, Jeremy M.C. and Francis, Ziad and Ivanchenko, Vladimir and Meylan, Sylvain and Murakami, Koichi and Okada, Shogo and Petrović, Ivan M. and Ristić-Fira, Aleksandra and Santin, Giovanni and Sarramia, David and Sasaki, Takashi and Shin, Wook-Geun and Tang, Nicolas and Tran, Hoang N and Villagrasa, Carmen and Emfietzoglou, Dimitris and Nieminen, Petteri and Guatelli, Susanna and Incerti, Sebastien", year = "2019", abstract = "The advancement of multidisciplinary research fields dealing with ionising radiation induced biological damage – radiobiology, radiation physics, radiation protection and, in particular, medical physics – requires a clear mechanistic understanding of how cellular damage is induced by ionising radiation. Monte Carlo (MC)simulations provide a promising approach for the mechanistic simulation of radiation transport and radiation chemistry, towards the in silico simulation of early biological damage. We have recently developed a fully integrated MC simulation that calculates early single strand breaks (SSBs)and double strand breaks (DSBs)in a fractal chromatin based human cell nucleus model. The results of this simulation are almost equivalent to past MC simulations when considering direct/indirect strand break fraction, DSB yields and fragment distribution. The simulation results agree with experimental data on DSB yields within 13.6% on average and fragment distributions agree within an average of 34.8%. © 2019 Associazione Italiana di Fisica Medica", journal = "Physica Medica", title = "Evaluation of early radiation DNA damage in a fractal cell nucleus model using Geant4-DNA", volume = "62", pages = "152-157", doi = "10.1016/j.ejmp.2019.04.010" }
Sakata, D., Lampe, N., Karamitros, M., Kyriakou, I., Belov, O., Bernal, M. A., Bolst, D., Bordage, M., Breton, V., Brown, J. M.C., Francis, Z., Ivanchenko, V., Meylan, S., Murakami, K., Okada, S., Petrović, I. M., Ristić-Fira, A., Santin, G., Sarramia, D., Sasaki, T., Shin, W., Tang, N., Tran, H. N., Villagrasa, C., Emfietzoglou, D., Nieminen, P., Guatelli, S.,& Incerti, S.. (2019). Evaluation of early radiation DNA damage in a fractal cell nucleus model using Geant4-DNA. in Physica Medica, 62, 152-157. https://doi.org/10.1016/j.ejmp.2019.04.010
Sakata D, Lampe N, Karamitros M, Kyriakou I, Belov O, Bernal MA, Bolst D, Bordage M, Breton V, Brown JM, Francis Z, Ivanchenko V, Meylan S, Murakami K, Okada S, Petrović IM, Ristić-Fira A, Santin G, Sarramia D, Sasaki T, Shin W, Tang N, Tran HN, Villagrasa C, Emfietzoglou D, Nieminen P, Guatelli S, Incerti S. Evaluation of early radiation DNA damage in a fractal cell nucleus model using Geant4-DNA. in Physica Medica. 2019;62:152-157. doi:10.1016/j.ejmp.2019.04.010 .
Sakata, Dousatsu, Lampe, Nathanael, Karamitros, Mathieu, Kyriakou, Ioanna, Belov, Oleg, Bernal, Mario A, Bolst, David, Bordage, Marie-Claude, Breton, Vincent, Brown, Jeremy M.C., Francis, Ziad, Ivanchenko, Vladimir, Meylan, Sylvain, Murakami, Koichi, Okada, Shogo, Petrović, Ivan M., Ristić-Fira, Aleksandra, Santin, Giovanni, Sarramia, David, Sasaki, Takashi, Shin, Wook-Geun, Tang, Nicolas, Tran, Hoang N, Villagrasa, Carmen, Emfietzoglou, Dimitris, Nieminen, Petteri, Guatelli, Susanna, Incerti, Sebastien, "Evaluation of early radiation DNA damage in a fractal cell nucleus model using Geant4-DNA" in Physica Medica, 62 (2019):152-157, https://doi.org/10.1016/j.ejmp.2019.04.010 . .