VinaR - Repository of the Vinča Nuclear Institute
    • English
    • Српски
    • Српски (Serbia)
  • English 
    • English
    • Serbian (Cyrilic)
    • Serbian (Latin)
  • Login
View Item 
  •   Vinar
  • Vinča
  • Radovi istraživača
  • View Item
  •   Vinar
  • Vinča
  • Radovi istraživača
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Evaluation of early radiation DNA damage in a fractal cell nucleus model using Geant4-DNA

Authorized Users Only
2019
Authors
Sakata, Dousatsu
Lampe, Nathanael
Karamitros, Mathieu
Kyriakou, Ioanna
Belov, Oleg
Bernal, Mario A
Bolst, David
Bordage, Marie-Claude
Breton, Vincent
Brown, Jeremy M.C.
Francis, Ziad
Ivanchenko, Vladimir
Meylan, Sylvain
Murakami, Koichi
Okada, Shogo
Petrović, Ivan M.
Ristić-Fira, Aleksandra
Santin, Giovanni
Sarramia, David
Sasaki, Takashi
Shin, Wook-Geun
Tang, Nicolas
Tran, Hoang N
Villagrasa, Carmen
Emfietzoglou, Dimitris
Nieminen, Petteri
Guatelli, Susanna
Incerti, Sebastien
Article (Published version)
,
© 2019 Associazione Italiana di Fisica Medica
Metadata
Show full item record
Abstract
The advancement of multidisciplinary research fields dealing with ionising radiation induced biological damage – radiobiology, radiation physics, radiation protection and, in particular, medical physics – requires a clear mechanistic understanding of how cellular damage is induced by ionising radiation. Monte Carlo (MC)simulations provide a promising approach for the mechanistic simulation of radiation transport and radiation chemistry, towards the in silico simulation of early biological damage. We have recently developed a fully integrated MC simulation that calculates early single strand breaks (SSBs)and double strand breaks (DSBs)in a fractal chromatin based human cell nucleus model. The results of this simulation are almost equivalent to past MC simulations when considering direct/indirect strand break fraction, DSB yields and fragment distribution. The simulation results agree with experimental data on DSB yields within 13.6% on average and fragment distributions agree within an ...average of 34.8%. © 2019 Associazione Italiana di Fisica Medica

Keywords:
Geant4-DNA / Monte Carlo simulation / DNA damage
Source:
Physica Medica, 2019, 62, 152-157
Projects:
  • CNRS PICS France - Greece [7340]
  • CNRS PICS France - Greece [8235]
  • CNRS PICS France - Serbia [8070]
  • IdEx Bordeaux University - France International Post-doctorates program of the "France-Japan Particle Physics Laboratory" International Associated Laboratory
  • IdEx Bordeaux University - France - International Doctorates program of the "France-Korea Particle Physics Laboratory" International Associated Laboratory (2017-2020)
  • Australian Research Council [ARC DP170100967]
  • ESA [4000112863/14/NL/HB]
  • CNPq [306775/2015-8]
  • FAPESP foundation in Brazil [2011/51594-2]
  • FAPESP foundation in Brazil [2015/21873-8]

DOI: 10.1016/j.ejmp.2019.04.010

ISSN: 1120-1797 (print); 1724-191X (electronic)

PubMed: 31109825

WoS: 000469329200017

Scopus: 2-s2.0-85065792241
[ Google Scholar ]
11
11
URI
https://linkinghub.elsevier.com/retrieve/pii/S1120179719300882
http://vinar.vin.bg.ac.rs/handle/123456789/8206
Collections
  • Radovi istraživača
Institution
Vinča

DSpace software copyright © 2002-2015  DuraSpace
About VinaR - Repository of the Vinča Institute of Nuclear Sciences | Send Feedback

OpenAIRERCUB
 

 

All of DSpaceInstitutionsAuthorsTitlesSubjectsThis institutionAuthorsTitlesSubjects

Statistics

View Usage Statistics

DSpace software copyright © 2002-2015  DuraSpace
About VinaR - Repository of the Vinča Institute of Nuclear Sciences | Send Feedback

OpenAIRERCUB