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dc.creatorJovanović, Snežana
dc.creatorBogojeski, Jovana V.
dc.creatorNikolić, Miloš V.
dc.creatorMijajlović, Marina Ž.
dc.creatorTomović, Dušan Lj.
dc.creatorBukonjić, Andriana M.
dc.creatorKnežević Rangelov, Sanja M.
dc.creatorMijailović, Nataša R.
dc.creatorRatković, Zoran
dc.creatorJevtić, Verica V.
dc.creatorPetrović, Biljana V.
dc.creatorTrifunović, Srećko R.
dc.creatorNovaković, Slađana B.
dc.creatorBogdanović, Goran A.
dc.creatorRadić, Gordana P.
dc.date.accessioned2019-08-20T10:18:13Z
dc.date.available2019-08-20T10:18:13Z
dc.date.issued2019
dc.identifier.issn0095-8972 (print)
dc.identifier.urihttps://www.tandfonline.com/doi/full/10.1080/00958972.2019.1610561
dc.identifier.urihttp://vinar.vin.bg.ac.rs/handle/123456789/8196
dc.description.abstractInteractions of copper(II) complexes which contain S-alkyl derivatives of thiosalicylic acid (alkyl = methyl, ethyl, propyl and butyl; aryl = benzyl), marked as 1–5, with guanosine-5′-monophosphate (5′-GMP) and calf thymus DNA (CT-DNA) were studied. Kinetics of substitution reactions of 1–5 with 5′-GMP and CT-DNA were investigated under pseudo-first-order conditions at 310 K and pH = 7.2 in 25 mM Hepes buffer using stopped-flow method. All complexes have high affinity toward studied bio-molecules. Additionally, interactions with CT-DNA were followed by absorption spectroscopy and fluorescence quenching measurements. The results indicate that complexes bind to DNA exhibiting high binding constants (Kb = 104 M−1). During the examination of competitive reactions with ethidium bromide (EB), results showed that complexes can replace EB-bound DNA. In addition, a new crystal structure of the binuclear Cu(II) complex with S-substituted thiosalicylate derivative has been reported. In the present series of Cu(II) complexes the crystal structure is the first example of a complex comprising an S-aryl derivative of thiosalicylate ligand. Through comparative study of structural properties of six molecules from four crystal structures we examined the structural variations, potentially important for biological activity of these complexes. © 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group.en
dc.language.isoen
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172011/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172035/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172016/RS//
dc.rightsrestrictedAccess
dc.sourceJournal of Coordination Chemistry
dc.subject5′-GMPen
dc.subjectCu(II) complexesen
dc.subjectDNAen
dc.subjectinteractionsen
dc.subjectkineticsen
dc.titleInteractions of binuclear copper(II) complexes with S-substituted thiosalicylate derivatives with some relevant biomoleculesen
dc.typearticleen
dc.rights.licenseARR
dcterms.abstractБогдановић, Горан; Радић, Гордана П; Богојески, Јована; Јовановић, Снежана; Николић, Милош В; Мијајловић, Марина Ж; Томовић, Душан Љ.; Букоњић, Aндриана М; Кнежевић Рангелов, Сања М; Мијаиловић, Наташа Р; Ратковић, Зоран; Јевтић, Верица В; Петровић, Биљана; Трифуновић, Р Срећко; Новаковић, Слађана;
dc.rights.holder© 2019 Informa UK Limited, trading as Taylor & Francis Group
dc.citation.volume72
dc.citation.issue10
dc.citation.spage1603
dc.citation.epage1620
dc.identifier.wos000485070500001
dc.identifier.doi10.1080/00958972.2019.1610561
dc.type.versionpublishedVersion
dc.identifier.scopus2-s2.0-85065676768


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